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EMPLICITI
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

EMPLICITI Rx

Generic Name and Formulations:
Elotuzumab 300mg, 400mg; per vial; lyophilized pwd for IV infusion after reconstitution; preservative-free.

Company:
Bristol-Myers Squibb

Therapeutic Use:

Indications for EMPLICITI:

In combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received 1–3 prior therapies.

Adult:

Give by IV infusion at initial rate of 0.5mL/min; may increase stepwise if no reactions develop; max rate 2mL/min (see full labeling). After 4 cycles, infusion rate may be increased up to max 5mL/min. Administer with lenalidomide and dexamethasone (see full labeling for dosing schedule). 10mg/kg every week for the first 2 cycles then every 2 weeks thereafter; continue until disease progression or unacceptable toxicity. Premedicate with dexamethasone, H1 blocker, H2 blocker, and acetaminophen before each infusion. Dose modifications: see full labeling.

Children:

Not established.

Contraindications:

Consult lenalidomide and dexamethasone prescribing information for contraindications before starting therapy.

Warnings/Precautions:

Interrupt infusion if Grade ≥2 infusion reactions occur and manage appropriately. Monitor for development of infections and treat promptly. Monitor for second primary malignancies. Monitor liver function periodically; discontinue if Grade ≥3 elevation of liver enzymes occur; consider resuming after return to baseline values. Pregnancy: not studied. Nursing mothers: not recommended.

Interactions:

May interfere with correct response classification in SPEP and serum immunofixation assays.

Pharmacological Class:

SLAMF7-directed immunostimulatory antibody.

Adverse Reactions:

Fatigue, diarrhea, pyrexia, constipation, cough, peripheral neuropathy, nasopharyngitis, upper respiratory tract infection, decreased appetite, pneumonia.

Note:

For lenalidomide and dexamethasone specific dosing and safety information, refer to the respective full prescribing labels.

Generic Availability:

NO

How Supplied:

Single-dose vial—1

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