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EFUDEX
Actinic keratoses
Melanoma and other skin cancers
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Drug Name:

EFUDEX Rx

Generic Name and Formulations:
Fluorouracil 2%, 5%; soln.

Company:
Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for EFUDEX:

Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see literature.

Adult:

Keratoses: Apply twice daily until erosion occurs (usually 2–4 wks). Basal cell carcinoma (5% only): Apply twice daily, usually for 3–6 weeks (obliteration may take 10–12 weeks).

Children:

Not recommended.

Contraindications:

Dihydropyrimidine dehydrogenase (DPD) deficiency. Pregnancy (Cat.X).

Warnings/Precautions:

Apply cautiously near eyes, nose, mouth. Avoid mucous membranes, occlusion, ulcerated/inflamed skin, exposure to UV light. Wash hands after application if fingers were used. Notify patients of expected skin reaction. Biopsy unresponsive lesions. Nursing mothers: not recommended.

See Also:

EFUDEX CREAM

Pharmacological Class:

Antimetabolite.

Adverse Reactions:

Pain or burning at application site, pruritus, irritation, hyperpigmentation.

How Supplied:

Soln—10mL (w. drop dispenser); Crm—25g

Indications for EFUDEX:

Multiple actinic or solar keratoses. Superficial basal cell carcinoma when conventional therapy is impractical (5% only); see literature.

Adult:

Keratoses: Apply twice daily until erosion occurs (usually 2–4 wks). Basal cell carcinoma (5% only): Apply twice daily, usually for 3–6 weeks (obliteration may take 10–12 weeks).

Children:

Not recommended.

Contraindications:

Dihydropyrimidine dehydrogenase (DPD) deficiency. Pregnancy (Cat.X).

Warnings/Precautions:

Apply cautiously near eyes, nose, mouth. Avoid mucous membranes, occlusion, ulcerated/inflamed skin, exposure to UV light. Wash hands after application if fingers were used. Notify patients of expected skin reaction. Biopsy unresponsive lesions. Nursing mothers: not recommended.

See Also:

EFUDEX CREAM

Pharmacological Class:

Antimetabolite.

Adverse Reactions:

Pain or burning at application site, pruritus, irritation, hyperpigmentation.

How Supplied:

Soln—10mL (w. drop dispenser); Crm—25g

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