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DYAZIDE
Edema
Hypertension
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Drug Name:

DYAZIDE Rx

Generic Name and Formulations:
Triamterene 37.5mg, hydrochlorothiazide 25mg; caps.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for DYAZIDE:

Edema.

Adult:

1–2 caps once daily.

Children:

Not recommended.

Contraindications:

Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.

Warnings/Precautions:

Risk of hyperkalemia; monitor frequently. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Diabetes. Acidosis predisposition. Electrolyte imbalance. Hypochloremia with metabolic alkalosis. Excess diuresis. History of renal stones. Gout. Surgery. SLE. Monitor electrolytes, renal function. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Severely ill. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digoxin, lithium toxicity. Hyperkalemia more likely with ACE inhibitors, parenteral penicillin G. Hypokalemia with ACTH, corticosteroids, amphotericin B. Hyponatremia with sulfonylureas. NSAIDs may cause renal failure. Adjust antidiabetic, antigout medications. May potentiate nondepolarizing muscle relaxants, antihypertensives. Antagonizes oral anticoagulants, methenamine. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (K+ sparing) + (thiazide).

Adverse Reactions:

Drowsiness, muscle cramps, weakness, headache, GI disturbances, dizziness, impotence, arrhythmias, hypotension, dry mouth, urine discoloration.

Generic Availability:

YES

How Supplied:

Caps—100, 1000

Indications for DYAZIDE:

Hypertension when normokalemia is essential.

Adult:

1–2 caps once daily.

Children:

Not recommended.

Contraindications:

Hyperkalemia. Renal impairment. Anuria. Sulfonamide allergy. Concomitant potassium or K+-sparing diuretics.

Warnings/Precautions:

Risk of hyperkalemia; monitor frequently. Discontinue if serum potassium >5.5mEq/L or <3mEq/L. Diabetes. Acidosis predisposition. Electrolyte imbalance. Hypochloremia with metabolic alkalosis. Excess diuresis. History of renal stones. Gout. Surgery. SLE. Monitor electrolytes, renal function. Hepatic impairment: monitor for hepatic coma, if confusion increases, discontinue for a few days. Severely ill. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digoxin, lithium toxicity. Hyperkalemia more likely with ACE inhibitors, parenteral penicillin G. Hypokalemia with ACTH, corticosteroids, amphotericin B. Hyponatremia with sulfonylureas. NSAIDs may cause renal failure. Adjust antidiabetic, antigout medications. May potentiate nondepolarizing muscle relaxants, antihypertensives. Antagonizes oral anticoagulants, methenamine. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (K+ sparing) + (thiazide).

Adverse Reactions:

Drowsiness, muscle cramps, weakness, headache, GI disturbances, dizziness, impotence, arrhythmias, hypotension, dry mouth, urine discoloration.

Generic Availability:

YES

How Supplied:

Caps—100, 1000

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