ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

DUTOPROL
Hypertension
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

DUTOPROL Rx

Generic Name and Formulations:
Metoprolol succinate ext-rel, hydrochlorothiazide; 25/12.5mg, 50/12.5mg, 100/12.5mg; tabs.

Company:
AstraZeneca Pharmaceuticals

Therapeutic Use:

Indications for DUTOPROL:

Hypertension.

Adult:

Individualize. Take once daily. Replacement therapy: may be substituted for individual components. Titrate, if necessary, every 2 weeks up to max 200/25mg. Severe renal impairment: not recommended. Moderate hepatic impairment: consider initiating with lower HCTZ component.

Children:

Not established.

Contraindications:

Cardiogenic shock. Overt heart failure. Sinus bradycardia. Sick sinus syndrome. 2nd- or 3rd-degree AV block unless paced. Anuria. Sulfonamide allergy.

Warnings/Precautions:

Ischemic heart disease. Worsening cardiac failure (reduce or interrupt dose if necessary). Bronchospastic disease. Monitor HR and rhythm; reduce dose or discontinue if severe bradycardia occurs. Pheochromocytoma. Major surgery. Renal or hepatic impairment. Volume depletion. Diabetes and hypoglycemia. Thyrotoxicosis (hyperthyroidism). Peripheral vascular disease. Acute myopia. Secondary angle-closure glaucoma. SLE. Gout. Post-sympathectomy. Avoid abrupt cessation (reduce dose over 1–2 weeks and monitor). Monitor electrolytes. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Additive effects with catecholamine-depleting drugs (eg, reserpine, MAOIs). Potentiated by CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone). Risk of bradycardia with digitalis, clonidine, diltiazem, verapamil. Potentiated by alcohol, barbituates, narcotics, other antihypertensives. Hypokalemia with corticosteroids, ACTH. May increase lithium toxicity. Antagonized by NSAIDs (monitor). Adjust antidiabetic drugs. Decreased absorption with cholestyramine and colestipol resins. Antagonizes epinephrine. Possible increased response to muscle relaxants (eg, tubocurarine). Beta-blockers may mask signs of hypoglycemia. May interfere with parathyroid tests.

Pharmacological Class:

Cardioselective beta-blocker + diuretic.

Adverse Reactions:

Nasopharyngitis, fatigue, dizziness, back pain, nausea; bronchospasm, bradycardia, CHF, heart block, vision disorders.

How Supplied:

Tabs—30

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs