Cognitive function is an important factor when considering oral therapy as an option for cancer treatment, particularly for elderly patients with cancer.
Omitting bleomycin from the treatment regimen for Hodgkin lymphoma in patients with negative findings on an interim PET scan led to a lower incidence of pulmonary toxic effects without significantly lowering treatment efficacy.
Comparative Efficacy and Safety of Axitinib Versus Sorafenib in Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-analysisJuly 07, 2016
[Oncotargets and Therapy] This research evaluates the comparative efficacy and safety of axitinib and sorafenib for the treatment of metastatic renal cell carcinoma.
Scientists developed an innovative nanoplatform to more effectively deliver RNA interference to anaplastic thyroid cancer (ATC) sites. ATC is the most aggressive form of thyroid cancer; mortality is almost 100% and median survival is 3 to 5 months.
Nonadherence to Noncancer Medication Schedules Predicts Adherence to Adjuvant Hormone Therapy for Breast CancerJune 28, 2016
Patients who do not adhere to their medication schedules for chronic conditions prior to a breast cancer diagnosis were twice as likely to skip oral adjuvant hormonal therapy.
In a randomized phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with ALL whose disease had relapsed following standard therapies, qualified for stem cell transplants after treatment with the drug.
Results from a clinical trial indicate that 2 topical creams compared favorably to photodynamic therapy for primary, low-risk superficial basal cell carcinoma.
PEG-IFN did not improve improve outcomes for patients with melanoma compared with IFN. Furthermore, patients receiving PEG-IFN were more likely to discontinue treatment due to toxicity.
A breakthrough technique in the manufacture of injectable drugs removed surfactants in an effort to reduce serious allergic reactions and other side effects, making injectable medicines safer.
A newly discovered synthesized drug reduced the viability of melanoma cells without affecting normal cells in cell culture and mouse xenograft models of the disease. The drug, HA15, is a type of thiazole benzenesulfonamide.
ASCO Statement Seeks to Balance Prescription Opioids for Patients With Cancer and Misuse and Abuse PreventionMay 31, 2016
ASCO addresses the complex issues surrounding prescription opioids in a new policy statement. ASCO supports the efforts of multiple federal offices and agencies to prevent and respond to prescription drug abuse, and is also working to protect access to appropriate medical opioid therapy for patients with cancer.
A new drug candidate reduced the growth of tumors in a mouse model of triple negative breast cancer (TNBC) by targeting the RNA, or expression, of a gene only expressed in the diseased cells.
A blood-based test pinpoints which patients with metastatic colorectal cancer will benefit from treatment with cetuximab.
Researchers have pinpointed the evolutionary process cancer cells use to resist the drug LOXO-101.
Tumors of varied types of genetically defined cancer were significantly reduced by the drug LOXO-101, according to phase 1 study results.
The effectiveness of chemotherapy was enhanced by targeting survivin, a protein that inhibits apoptosis or cell death, according to preclinical research in cells and mouse models of retinoblastoma.
A small, phase I clinical trial indicates the experimental drug guadecitabine is safe in combination with the chemotherapy drug irinotecan, and it may overcome resistance to irinotecan in patients with metastatic colorectal cancer.
Continuation of ceritinib therapy beyond disease progression was associated with prolonged survival, according to results from a retrospective study of the use of ceritinib to treat advanced ALK-positive NSCLC.
Some of our patients receive olanzapine (Zyprexa) as an antiemetic. Is this a typical use of this drug?
Microneedles embedded in a patch deliver cancer immunotherapy treatment directly to the site of melanoma, according to preliminary findings in animal studies.
The growth of medulloblastoma was inhibited by a new drug in research conducted in cell cultures and mice. This study targeted a particularly aggressive form of the disease driven by the oncogene MYC.
Sulforaphane, found in broccoli and other cruciferous vegetables such as cauliflower and kale, may increase the susceptibility of a subset of cancer to prodrug treatments while avoiding harm to normal tissues.
New research has shed light on how some tumors continue their growth despite treatment with kinase inhibitors, and on how a combination of drugs can yield much better results.
A new drug might help successfully treat mesothelioma, one of the deadliest cancers, according to results from cell culture and mouse xenograft models of the disease.
A subtype-specific weakness of T-cell acute lymphoblastic leukemia (T-ALL) could enable improved treatment, according to results from a a recent study using a mouse model.
A new therapy might help treat a rare, high-risk cancer that begins development in the fetus or embryo, neuroblastoma, according to recent results from cell culture experiments.
Adding Palbociclib to Fulvestrant Improves Progression-free Survival in Select Women With Metastatic Breast CancerMarch 22, 2016
Progression-free survival was significantly and consistently improved when palbociclib was added to fulvestrant, compared with placebo and fulvestrant, for women with stage IV breast cancer that is hormone-receptor-positive and HER2-negative.
Combining birinapant with a p38 inhibitor is a promising therapeutic regimen for patients with acute myeloid leukemia (AML).
An implantable device allows large doses of highly toxic drugs to be delivered directly to pancreatic tumors while reducing exposure to the toxic side effects in the rest of the body.
How is loratadine used to treat bone pain in patients receiving white blood cell growth factors?
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