Drug Therapy

Targeted Therapy Enhances Chemotherapy, Improves Outcomes in Retinoblastoma

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The effectiveness of chemotherapy was enhanced by targeting survivin, a protein that inhibits apoptosis or cell death, according to preclinical research in cells and mouse models of retinoblastoma.

Early Study Results Show Guadecitabine Effective for Metastatic Colorectal Cancer

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A small, phase I clinical trial indicates the experimental drug guadecitabine is safe in combination with the chemotherapy drug irinotecan, and it may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

Survival Prolonged by Continuing Ceritinib Beyond Disease Progression in Non-small Cell Lung Cancer

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Continuation of ceritinib therapy beyond disease progression was associated with prolonged survival, according to results from a retrospective study of the use of ceritinib to treat advanced ALK-positive NSCLC.

Using Olanzapine as an Antiemetic for Patients Undergoing Moderate or High-Emetic Risk Chemotherapy

Using Olanzapine as an Antiemetic for Patients Undergoing Moderate or High-Emetic Risk Chemotherapy

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Some of our patients receive olanzapine (Zyprexa) as an antiemetic. Is this a typical use of this drug?

Microneedle Patch Delivers Localized Immunotherapy for Melanoma

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Microneedles embedded in a patch deliver cancer immunotherapy treatment directly to the site of melanoma, according to preliminary findings in animal studies.

Novel Drug Combination Inhibits Growth of MYC-driven Medulloblastoma

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The growth of medulloblastoma was inhibited by a new drug in research conducted in cell cultures and mice. This study targeted a particularly aggressive form of the disease driven by the oncogene MYC.

Broccoli Compound May Improve Efficacy of Cancer Prodrug

Broccoli Compound May Improve Efficacy of Cancer Prodrug

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Sulforaphane, found in broccoli and other cruciferous vegetables such as cauliflower and kale, may increase the susceptibility of a subset of cancer to prodrug treatments while avoiding harm to normal tissues.

Combination Drug Therapy May Prevent Tumors From Sidestepping Kinase Inhibitors

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New research has shed light on how some tumors continue their growth despite treatment with kinase inhibitors, and on how a combination of drugs can yield much better results.

Research Shows Drug Inhibits Mesothelioma Growth

Research Shows Drug Inhibits Mesothelioma Growth

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A new drug might help successfully treat mesothelioma, one of the deadliest cancers, according to results from cell culture and mouse xenograft models of the disease.

New Possible Treatment Addresses Specific Type of Leukemia

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A subtype-specific weakness of T-cell acute lymphoblastic leukemia (T-ALL) could enable improved treatment, according to results from a a recent study using a mouse model.

New Therapy Holds Potential for Neuroblastoma Treatment

New Therapy Holds Potential for Neuroblastoma Treatment

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A new therapy might help treat a rare, high-risk cancer that begins development in the fetus or embryo, neuroblastoma, according to recent results from cell culture experiments.

Adding Palbociclib to Fulvestrant Improves Progression-free Survival in Select Women With Metastatic Breast Cancer

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Progression-free survival was significantly and consistently improved when palbociclib was added to fulvestrant, compared with placebo and fulvestrant, for women with stage IV breast cancer that is hormone-receptor-positive and HER2-negative.

Combination Improves Anticancer Activity of 2 Agents in Acute Myeloid Leukemia

Combination Improves Anticancer Activity of 2 Agents in Acute Myeloid Leukemia

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Combining birinapant with a p38 inhibitor is a promising therapeutic regimen for patients with acute myeloid leukemia (AML).

Implantable Device Delivers Anticancer Regimen Directly Into Pancreatic Cancer Tumors

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An implantable device allows large doses of highly toxic drugs to be delivered directly to pancreatic tumors while reducing exposure to the toxic side effects in the rest of the body.

Bone Pain Due to White Blood Cell Growth Factors

Bone Pain Due to White Blood Cell Growth Factors

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How is loratadine used to treat bone pain in patients receiving white blood cell growth factors?

Antibiotics and Cardiac Glycosides May Be Effective Cancer Treatments

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Medications normally used to treat infections and heart conditions are promising cancer treatments. These drugs were previously not known to have roles in modifying cellular epigenetics.

Interactions of Cancer-causing Gene May Lead to Therapeutic Target

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An exploration of the interaction between the protein produced by the common cancer-causing KRAS gene and the AGO2 protein may lead to the possibility of interrupting the KRAS-AGO2 interaction as a possible therapy.

Novel Therapeutic Demonstrates Effectiveness Against Castration-resistant Prostate Cancer

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The growth of castration-resistant prostate cancer cells was reduced by a first-in-class sphingosine kinase 2 inhibitor, but the cells were not killed.

Fly Model Identifies Targeted Combination Therapy for NSCLC

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Combining a drug indicated for melanoma with a common cholesterol-lowering drug may control the growth of NSCLC, according to research in fruit flies and human lung cancer cell lines.

Nanoparticle System Uses Light Waves to Target Release Site of Drug

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Nanoparticles that release a drug only when exposed to near-infrared (NIR) light are a promising drug-delivery agent developed by Canadian researchers.

Nanoparticle Drug Delivery Aims to Control Pancreatic Tumor and Inhibit Escape Pathways

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Use of a nanoparticle to deliver drugs may reduce tumors and suppress metastatic escape. These efforts offer a way to control drug release over space and time while reducing systemic drug exposure and the associated side effects.

Natural Nanoparticles Effectively Deliver Drug Therapy in Resistant Lung Cancer

Natural Nanoparticles Effectively Deliver Drug Therapy in Resistant Lung Cancer

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Exosome serves as a natural nanoparticle delivery system and achieves the same cancer-killing effect on drug-resistant lung cancer as current formulations of drug therapy with 50x less drug.

Progression-free Survival of Patients With Neuroendocrine Tumors Improved With Everolimus

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A new analysis of a phase III trial of patients with neuroendocrine tumors that began in the gastrointestinal (GI) tract or at an unknown primary location found that progression-free survival was improved with everolimus by 6 to 8 months compared with placebo.

Link Between Obesity and Increased Risk for Colorectal Cancer May Be Therapy Target

Link Between Obesity and Increased Risk for Colorectal Cancer May Be Therapy Target

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A drug currently approved for GI conditions may prevent the development of colorectal cancer, according to researchers who revealed a biological connection between obesity and increased risk for colorectal cancer.

Prescription Coverage Impacts Treatment Adherence in Breast Cancer, Even for Low-cost Drugs

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Patients with breast cancer whose health insurance plans included prescription drug benefits were 10% more likely to start important hormonal therapy than patients who did not have prescription drug coverage.

CSF1R Inhibition May Ease Debilitating Adverse Event of Ovarian Cancer

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Women who have ovarian cancer often develop ascites, a buildup of fluids in the abdomen. Researchers have found that ascites can be reduced with minimal side effects through inhibition of the colony-stimulating-factor-1 receptor (CSF1R).

Breakthrough Advance Announced in International Blood Cancer Drug Trial

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Researchers announced a breakthrough advance in a world-first international clinical trial of a new drug to treat chronic lymphocytic leukemia and non-Hodgkin lymphoma that is refractory or resistant to current chemotherapies.

New Therapy for Triple-negative Breast Cancer Shows Promise in Laboratory Studies

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Recent laboratory findings provide novel insight into potential new therapeutic approaches for triple-negative breast cancer, a particularly difficult-to-treat and aggressive form of the disease.

Atezolizumab Set to Change Refractory Lung Cancer Treatment

Atezolizumab Set to Change Refractory Lung Cancer Treatment

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Atezolizumab may substantially change treatment strategies for patients with refractory lung cancer, according the first efficacy results from the POPLAR and BIRCH studies, which studied the PD-L1 antibody across treatment lines.

Two-Drug Combination Significantly Improves Overall Survival in Patients With Melanoma

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Current results from a clinical trial comparing a combination of two targeted therapies with a single-agent treatment for advanced melanoma has shown patients are living significantly longer with the combination therapy.

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