Drug Therapy

Topical Skin Creams Are Effective in Treatment of Superficial Basal Cell Carcinoma

Topical Skin Creams Are Effective in Treatment of Superficial Basal Cell Carcinoma

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Results from a clinical trial indicate that 2 topical creams compared favorably to photodynamic therapy for primary, low-risk superficial basal cell carcinoma.

Outcomes Are Not Improved With Pegylated Interferon Alpha-2a vs Interferon Alpha-2a

Outcomes Are Not Improved With Pegylated Interferon Alpha-2a vs Interferon Alpha-2a

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PEG-IFN did not improve improve outcomes for patients with melanoma compared with IFN. Furthermore, patients receiving PEG-IFN were more likely to discontinue treatment due to toxicity.

Novel Drug Manufacturing Technique Removes Excess Additives, Reduces Serious Allergic Reactions

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A breakthrough technique in the manufacture of injectable drugs removed surfactants in an effort to reduce serious allergic reactions and other side effects, making injectable medicines safer.

Modified Thiazole Benzenesulfonamide Demonstrates Anticancer Activity in Melanoma

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A newly discovered synthesized drug reduced the viability of melanoma cells without affecting normal cells in cell culture and mouse xenograft models of the disease. The drug, HA15, is a type of thiazole benzenesulfonamide.

ASCO Statement Seeks to Balance Prescription Opioids for Patients With Cancer and Misuse and Abuse Prevention

ASCO Statement Seeks to Balance Prescription Opioids for Patients With Cancer and Misuse and Abuse Prevention

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ASCO addresses the complex issues surrounding prescription opioids in a new policy statement. ASCO supports the efforts of multiple federal offices and agencies to prevent and respond to prescription drug abuse, and is also working to protect access to appropriate medical opioid therapy for patients with cancer.

Drug Candidate Successful in Targeting Cancer-Causing RNA

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A new drug candidate reduced the growth of tumors in a mouse model of triple negative breast cancer (TNBC) by targeting the RNA, or expression, of a gene only expressed in the diseased cells.

Biomarker Indicates Which Patients With Colorectal Cancer Will Respond to Cetuximab

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A blood-based test pinpoints which patients with metastatic colorectal cancer will benefit from treatment with cetuximab.

Research Reveals Evolution of TRK-fusion Inhibitor Resistance in Cancer

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Researchers have pinpointed the evolutionary process cancer cells use to resist the drug LOXO-101.

Tumor Regression Achieved With LOXO-101 in Phase 1 Study

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Tumors of varied types of genetically defined cancer were significantly reduced by the drug LOXO-101, according to phase 1 study results.

Targeted Therapy Enhances Chemotherapy, Improves Outcomes in Retinoblastoma

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The effectiveness of chemotherapy was enhanced by targeting survivin, a protein that inhibits apoptosis or cell death, according to preclinical research in cells and mouse models of retinoblastoma.

Early Study Results Show Guadecitabine Effective for Metastatic Colorectal Cancer

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A small, phase I clinical trial indicates the experimental drug guadecitabine is safe in combination with the chemotherapy drug irinotecan, and it may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

Survival Prolonged by Continuing Ceritinib Beyond Disease Progression in Non-small Cell Lung Cancer

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Continuation of ceritinib therapy beyond disease progression was associated with prolonged survival, according to results from a retrospective study of the use of ceritinib to treat advanced ALK-positive NSCLC.

Using Olanzapine as an Antiemetic for Patients Undergoing Moderate or High-Emetic Risk Chemotherapy

Using Olanzapine as an Antiemetic for Patients Undergoing Moderate or High-Emetic Risk Chemotherapy

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Some of our patients receive olanzapine (Zyprexa) as an antiemetic. Is this a typical use of this drug?

Microneedle Patch Delivers Localized Immunotherapy for Melanoma

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Microneedles embedded in a patch deliver cancer immunotherapy treatment directly to the site of melanoma, according to preliminary findings in animal studies.

Novel Drug Combination Inhibits Growth of MYC-driven Medulloblastoma

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The growth of medulloblastoma was inhibited by a new drug in research conducted in cell cultures and mice. This study targeted a particularly aggressive form of the disease driven by the oncogene MYC.

Broccoli Compound May Improve Efficacy of Cancer Prodrug

Broccoli Compound May Improve Efficacy of Cancer Prodrug

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Sulforaphane, found in broccoli and other cruciferous vegetables such as cauliflower and kale, may increase the susceptibility of a subset of cancer to prodrug treatments while avoiding harm to normal tissues.

Combination Drug Therapy May Prevent Tumors From Sidestepping Kinase Inhibitors

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New research has shed light on how some tumors continue their growth despite treatment with kinase inhibitors, and on how a combination of drugs can yield much better results.

Research Shows Drug Inhibits Mesothelioma Growth

Research Shows Drug Inhibits Mesothelioma Growth

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A new drug might help successfully treat mesothelioma, one of the deadliest cancers, according to results from cell culture and mouse xenograft models of the disease.

New Possible Treatment Addresses Specific Type of Leukemia

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A subtype-specific weakness of T-cell acute lymphoblastic leukemia (T-ALL) could enable improved treatment, according to results from a a recent study using a mouse model.

New Therapy Holds Potential for Neuroblastoma Treatment

New Therapy Holds Potential for Neuroblastoma Treatment

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A new therapy might help treat a rare, high-risk cancer that begins development in the fetus or embryo, neuroblastoma, according to recent results from cell culture experiments.

Adding Palbociclib to Fulvestrant Improves Progression-free Survival in Select Women With Metastatic Breast Cancer

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Progression-free survival was significantly and consistently improved when palbociclib was added to fulvestrant, compared with placebo and fulvestrant, for women with stage IV breast cancer that is hormone-receptor-positive and HER2-negative.

Combination Improves Anticancer Activity of 2 Agents in Acute Myeloid Leukemia

Combination Improves Anticancer Activity of 2 Agents in Acute Myeloid Leukemia

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Combining birinapant with a p38 inhibitor is a promising therapeutic regimen for patients with acute myeloid leukemia (AML).

Implantable Device Delivers Anticancer Regimen Directly Into Pancreatic Cancer Tumors

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An implantable device allows large doses of highly toxic drugs to be delivered directly to pancreatic tumors while reducing exposure to the toxic side effects in the rest of the body.

Bone Pain Due to White Blood Cell Growth Factors

Bone Pain Due to White Blood Cell Growth Factors

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How is loratadine used to treat bone pain in patients receiving white blood cell growth factors?

Antibiotics and Cardiac Glycosides May Be Effective Cancer Treatments

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Medications normally used to treat infections and heart conditions are promising cancer treatments. These drugs were previously not known to have roles in modifying cellular epigenetics.

Interactions of Cancer-causing Gene May Lead to Therapeutic Target

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An exploration of the interaction between the protein produced by the common cancer-causing KRAS gene and the AGO2 protein may lead to the possibility of interrupting the KRAS-AGO2 interaction as a possible therapy.

Novel Therapeutic Demonstrates Effectiveness Against Castration-resistant Prostate Cancer

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The growth of castration-resistant prostate cancer cells was reduced by a first-in-class sphingosine kinase 2 inhibitor, but the cells were not killed.

Fly Model Identifies Targeted Combination Therapy for NSCLC

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Combining a drug indicated for melanoma with a common cholesterol-lowering drug may control the growth of NSCLC, according to research in fruit flies and human lung cancer cell lines.

Nanoparticle System Uses Light Waves to Target Release Site of Drug

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Nanoparticles that release a drug only when exposed to near-infrared (NIR) light are a promising drug-delivery agent developed by Canadian researchers.

Nanoparticle Drug Delivery Aims to Control Pancreatic Tumor and Inhibit Escape Pathways

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Use of a nanoparticle to deliver drugs may reduce tumors and suppress metastatic escape. These efforts offer a way to control drug release over space and time while reducing systemic drug exposure and the associated side effects.

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