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 Drug Therapy

Posttransplant lenalidomide can slow down multiple myeloma

Delicia Honen Yard May 29, 2012

Lenalidomide use after autologous stem-cell transplant significantly improved progression-free and overall survival in patients with myeloma.
 

Modified stem cells keep glioblastoma at bay

Delicia Honen Yard May 25, 2012

Three patients with glioblastoma lived longer than predicted after receiving transplants of their own blood stem cells that had been gene-modified.
 

Administering tumor necrosis factor medications

May 22, 2012

Do all tumor necrosis factor medications for rheumatoid arthritis require 1.2 micron filter tubing?
 

SPECT/CT guides postop management of thyroid cancer

Delicia Honen Yard May 21, 2012

Information from SPECT/ CT scans helps determine the need for radioiodine therapy in persons with thyroid cancer and influences follow-up strategy.
 

Cancer pain often undertreated, especially among minorities

Delicia Honen Yard May 16, 2012

One-third of outpatients with breast, prostate, colon/rectum, or lung cancer were receiving insufficient pain treatment, particularly minorities.
 

Potentially treatable side effects plague breast cancer survivors for years

Delicia Honen Yard May 11, 2012

Six years after breast cancer treatment, more than 60% of women experienced at least one side effect amenable to rehabilitative intervention.
 

Fewer cycles of higher-dose chemotherapy best in advanced Hodgkin lymphoma

Delicia Honen Yard May 10, 2012

Six cycles of higher-dose chemotherapy, not the standard eight cycles or a lower-dose variant, should be the treatment of choice for advanced Hodgkin.
 

Lung cancer drug lowers testosterone

Delicia Honen Yard May 09, 2012

Crizotinib appears to be the culprit in reducing testosterone levels among men taking the drug as a treatment for a form of lung cancer.
 

Experimental agent acts against aggressive lymphoma subtype

Delicia Honen Yard May 03, 2012

The drug ibrutinib can provide significant anticancer responses with modest side effects in persons with diffuse large B-cell lymphomas (DLBCLs).
 

PET response signals increased survival in soft-tissue sarcoma

Delicia Honen Yard May 02, 2012

Patients with soft-tissue sarcoma who have an early PET response after initial chemotherapy survive longer than patients showing no such response.
 

A second gene may predispose women to breast cancer

April 30, 2012

Scientists have discovered that the Abraxas gene may advance the mission of BRCA1 and may even act on its own to help breast cancer develop.
 

Mutations in XRCC2 gene tied to breast cancer risk

Delicia Honen Yard April 26, 2012

Mutations in a gene called XRCC2 have been linked to breast cancer susceptibility in families with none of the currently known breast-risk genes.
 

No link between BMI and surgical outcome in esophageal cancer

Delicia Honen Yard April 25, 2012

BMI appears to have no bearing on surgical complications or survival after esophagectomy following neoadjuvant chemoradiotherapy for adenocarcinoma.
 

New marker flags DNA repair response to platinum therapy

Delicia Honen Yard April 24, 2012

A new marker of DNA damage may predict which triple-negative breast cancers or serous ovarian cancers will respond to platinum-based chemotherapy.
 

Opioids may spur tumor growth

Delicia Honen Yard April 20, 2012

Although opioid-based painkillers are a standard treatment for relieving cancer pain, they may actually contribute to disease progression.
 

Wayward gene found, vanquished in some East Asians with CML and NSCLC

Delicia Honen Yard April 18, 2012

Researchers found that a gene mutation prevents tyrosine kinase inhibitors from working in some East Asian cancer patients, and can correct this.
 

Cabazitaxel (Jevtana)

April 17, 2012

Cabazitaxel is a taxane derivative indicated for treatment of hormone-refractory metastatic prostate cancer in patients previously treated with a docetaxel-containing regimen.
 

Genetic profile IDs leukemia patients for high-dose chemotherapy

Delicia Honen Yard April 17, 2012

Persons with acute myeloid leukemia who harbor specific gene mutations may have improved overall survival with higher doses of chemotherapy.
 

FDA acts on cancer drug shortages

April 17, 2012

In response to critical shortages, the FDA has issued draft guidance on mandatory and voluntary notifications to the agency.
 

Leukemia: Understanding its types and treatments

April 13, 2012

This review describes the four major groups of leukemia, plus diagnostic tests and treatment regimens for each group.
 

Heart risks of cancer drugs underestimated

Delicia Honen Yard April 12, 2012

The system for monitoring adverse events in oncology clinical trials is in urgent need of reform, say the authors of a recent commentary.
 

Many women with cancer missing fertility risk info, services

Delicia Honen Yard April 11, 2012

Few women of childbearing age who are diagnosed with cancer are taking steps to preserve their fertility during treatment.
 

More evidence shows aspirin might stave off cancer

April 05, 2012

Results from three new studies are consistent with earlier findings that aspirin can reduce cancer risk and, in some cases, metastasis.
 

Asian breast cancer patients unaware of "chemobrain"

April 04, 2012

The cognitive effects of chemotherapy are unfamiliar to Asian breast cancer patients even though these disturbances have affected their daily lives.
 

Protein fights protein to keep bladder cancer away from the lungs

April 03, 2012

Researchers have found what they believe to be a new mechanism of metastasis suppression that prevents bladder cancer from spreading to the lungs.
 

Childhood leukemia gets "theranostic" treatment

Delicia Honen Yard March 30, 2012

A new treatment platform combines a selective diagnostic test with targeted therapy for youths with acute lymphoblastic leukemia.
 

Survival improves for youths with leukemia

Delicia Honen Yard March 29, 2012

The 5-year survival rate for children and adolescents with acute lymphoblastic leukemia rose from 83.7% for 1990-1994 to 90.4% for 2000-2005.
 

Cancer of the appendix differs from colorectal cancer after all

Delicia Honen Yard March 26, 2012

Gene expression profiling has demonstrated that appendiceal cancer is quite distinct from colorectal cancer and may require different treatment.
 

Abscopal effect strengthens combination therapy in a melanoma patient

March 21, 2012

Combination therapy may be a promising treatment approach for patients with advanced melanoma who experience the abscopal effect.
 

Long-term cognitive effects seen with once-common breast chemotherapy regimen

Delicia Honen Yard March 19, 2012

Cognitive deficits subsequent to breast cancer chemotherapy using cyclophosphamide, methotrexate, and fluorouracil can be long-lasting.
 

Web Exclusives

Posttransplant lenalidomide can slow down multiple myeloma

Delicia Honen Yard May 29, 2012

Lenalidomide use after autologous stem-cell transplant significantly improved progression-free and overall survival in patients with myeloma.
 

Melanoma genome study implicates sun and new genetic culprits

Delicia Honen Yard May 28, 2012

Genetic mutations increased along with chronic sun exposure in persons with melanoma, and yet another gene may contribute to disease risk as well.
 

Modified stem cells keep glioblastoma at bay

Delicia Honen Yard May 25, 2012

Three patients with glioblastoma lived longer than predicted after receiving transplants of their own blood stem cells that had been gene-modified.
 

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