Drug Safety

FDA Reconsidering Safety Training for Doctors Prescribing Opioids

FDA Reconsidering Safety Training for Doctors Prescribing Opioids

Next week, FDA committee of outside experts will meet to review risk-management plans

FDA Wants Generic Opioids to Be More Abuse-Deterrent

FDA Wants Generic Opioids to Be More Abuse-Deterrent

In the latest step to combat the epidemic of opioid abuse, U.S. officials urge generic drug makers to make changes to opioids.

Clinicians Respond to New CDC Opioid Guidelines

Clinicians Respond to New CDC Opioid Guidelines

Mainly supportive of guidelines, but concerns include a lack of evidence underlying some new recommendations.

Handling Closed System Device-Incompatible Chemotherapy Agents

Handling Closed System Device-Incompatible Chemotherapy Agents

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How can accidental exposure/leaks when handling chemotherapy drugs that incompatible with the closed system device (CSD) be prevented?

Initial Safety Report Finds Acceptable Safety With Ibrutinib for Asymptomatic, High-Risk CLL

Initial Safety Report Finds Acceptable Safety With Ibrutinib for Asymptomatic, High-Risk CLL

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ONA presents an exclusive report on the initial findings on the safety profile of ibrutinib in asymptomatic patients with CLL, as presented at the International Workshop on Chronic Lymphocytic Leukemia.

Personal protective equipment (PPE) guidelines for handling monoclonal antibodies (MABs)

Personal protective equipment (PPE) guidelines for handling monoclonal antibodies (MABs)

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Is there a new consensus about wearing personal protective equipment (PPE) when handling monoclonal antibodies (MABs) for infusion?

United States to tighten controls on narcotic painkillers

United States to tighten controls on narcotic painkillers

The U.S. Drug Enforcement Administration (DEA) to enact tough new controls on painkillers containing hydrocodone, which has been tied to a surge in addictions across the United States.

Can docetaxel cause intoxication in cancer patients?

Can docetaxel cause intoxication in cancer patients?

The FDA issued an alert last Friday that some patients have reported feeling intoxicated after receiving their infusions of the chemotherapeutic drug, docetaxel.

Liquid nicotine for e-cigarettes can pose serious health threat

Liquid nicotine for e-cigarettes can pose serious health threat

A potent, liquid form of nicotine poses a serious and potentially deadly threat, but is sold legally in stores across the United States and online.

A roundup of FDA oncology news from September 2013

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The FDA approved Perjeta (pertuzumab) for the neoadjuvant treatment of breast cancer, first generic version of Xeloda (capecitabine) has gained FDA approval, and other FDA actions.

Pazopanib tolerated best in kidney cancer study

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A trial comparing pazopanib and sunitinib found pazopanib to have better safety and health-related quality-of-life profiles among persons with metastatic renal cell carcinoma.

What happens during a NIOSH HHE of an oncology clinic?

What happens during a NIOSH HHE of an oncology clinic?

Although chemotherapy drugs can be lifesaving for patients with cancer, they can be toxic to nurses and other health care personnel who handle them. Nurses should protect themselves through the use of proper handling techniques. A regular review of safe chemotherapy...

Consuming regular orange juice during drug therapy

Consuming regular orange juice during drug therapy

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Does consumption of regular orange juice cause drug interactions, or should all citrus fruits be avoided?

Project Improves Knowledge, Skills of Non-Chemotherapy Nurse Providers in Caring for Patients Requiring Chemotherapy

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A program that educates non-chemotherapy provider nurses about how to administer and safely handle chemotherapy drugs improved their knowledge and skills, found research presented at the 38th ONS Annual Congress,

A Closed-System Drug Transfer Device Helps Reduce Exposure to Hazardous Drugs

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Implementing closed-system transfer devices minimized variability in infusion setup of hazardous drugs, which also limited occupational exposure while standardizing administration, found research presented at the ONS 38th Annual Congress.

Splitting or crushing oral cancer medications

Splitting or crushing oral cancer medications

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Which medicines can be split or crushed for administration?

FDA urges opioid prescribers to participate in CME training

FDA urges opioid prescribers to participate in CME training

Prescribers of extended-release/long-acting opioid analgesics are encouraged to participate in continuing medical education provided by manufacturers of these analgesics.

IOM urges international action to eradicate fake drugs

IOM urges international action to eradicate fake drugs

Falsified and substandard medications pose public health problems around the world, and international action should be taken to combat the phenomenon.

Vaccinations for cancer patients

Vaccinations for cancer patients

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What vaccines are appropriate or not appropriate for cancer patients?

FDA: Draft guidance issued on abuse-deterrent opioids

FDA: Draft guidance issued on abuse-deterrent opioids

To assist industry in developing new formulations of opioid drugs with abuse-deterrent properties.

Pomalidomide extends survival in multiple myeloma

A new immunomodulatory drug under FDA review significantly increased survival in persons with multiple myeloma, including older patients.

Zytiga approved for metastatic prostate cancer

The FDA has expanded the indication for abiraterone acetate (Zytiga tablets) to combat metastatic castration-resistant prostate cancer.

Ibrutinib appears safe, effective against chronic lymphocytic leukemia

Ibrutinib, which targets the Bruton's tyrosine kinase to combat chronic lymphocytic leukemia, showed promising results in two phase II studies.

Some breast cancers may respond to anti-androgen drug

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Newly approved for prostate cancer, enzalutamide may be useful as a therapeutic agent in breast cancer that evades other treatments.

Antidepressants' effect on tamoxifen

Antidepressants' effect on tamoxifen

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Which antidepressants are important to be aware of with patients on tamoxifen (Nolvadex)?

FDA pulls 32-mg IV ondansetron dose from market

The 32-mg, single IV dose of the anti-nausea drug Zofran (ondansetron) will no longer be sold due to the potential for serious cardiac risks.

Food-drug interactions with oral TKIs

Food-drug interactions with oral TKIs

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What is the significance of food-drug interactions especially with oral agents such as nilotinib (Tasigna), sunitinib (Sutent), sorafenib (Nexavar), and erlotinib (Tarceva), to name a few?

Everolimus shrinks astrocytoma brain tumors

The mTOR inhibitor dramatically reduced the volume of subependymal giant cell astrocytomas (SEGAs) in persons with tuberous sclerosis complex.

Withdrawn leukemia drug has good results in UK study

Gemtuzumab ozogamicin, discontinued here in 2010, reduced relapse risk and improved survival in Welsh patients with acute myeloid leukemia.

Remind patients that supplements can have adverse effects

Persons with cancer who use herbs or dietary supplements are at risk for harmful drug interactions, a new study has reiterated.

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