Drug Resistance

New Research Identifies Potential Bladder Cancer Chemotherapy Side Effect

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A recent study undertaken sought to examine the effects of chemotherapy on bladder cancer cells and possible connections to later treatment resistance.

Recently Discovered microRNA Controls Response to Oxaliplatin in Colorectal Cancer

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Danish researchers identified a microRNA shown to predict whether a patient with colorectal cancer would be resistant to oxaliplatin treatment, a discovery that holds promise of improving both current treatment options and development of future treatment strategies.

Understanding a Molecular Switch Modulating Tumor Metastasis and Chemotherapy Resistance

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Dab2 is an endocytic adaptor and tumor suppressor whose expression occurs during the epithelial-mesenchymal transition, which is mediated by TGF-beta. This study sought to understand how Dab2 regulates apoptosis.

T Cells Have the Potential to Reverse Chemotherapy Resistance in Patients With Ovarian Cancer

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A new perspective on chemotherapy resistance in ovarian cancer may be a step toward overcoming that resistance. Fibroblasts block chemotherapy, leading to chemotherapy resistance; however, immune system T cells can reverse that resistance.

Hsp90 Inhibition Overcomes Hormone Resistance in Some Aggressive Prostate Cancers

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The second-generation hsp90 inhibitor onalespib may be beneficial for men with prostate cancer that no longer responds to androgen deprivation therapy

Research Reveals Evolution of TRK-fusion Inhibitor Resistance in Cancer

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Researchers have pinpointed the evolutionary process cancer cells use to resist the drug LOXO-101.

HIV Drug Could Re-sensitize Therapy-resistant Melanoma

HIV Drug Could Re-sensitize Therapy-resistant Melanoma

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The expression of the PAX3 and MITF genes in melanoma can cause early, nonmutational, reversible drug resistance; tissues that express these genes can then later develop mutational, irreversible drug resistance. The HIV drug nelfinavir can prevent this resistance.

Cell Growth Inhibitor Overcomes Therapy Resistance and Delays Tumor Recurrence in Breast Cancer

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Cyclin D1/CDK4 inhibitor treatment overcame resistance to targeted therapy in transgenic mouse models, cell cultures, and human tissue samples of HER2-positive breast cancer.

Targeting Long noncoding RNAs in Breast Cancer May Prevent Tamoxifen Resistance

Targeting Long noncoding RNAs in Breast Cancer May Prevent Tamoxifen Resistance

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New study findings presented at SABCS 2015 suggest that BRCAT431 promotes tamoxifen resistance, thereby increasing the clinical risk of recurrence and metastases in breast cancer.

Peptide Reverses Temozolomide Resistance in Glioblastoma Cells

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Scientists have discovered how to sensitize drug-resistant human glioblastoma cells to chemotherapy.

Blood Test Indicates Breast Cancer Tumors Developed Resistance to Hormone Treatment

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Scientists developed a highly sensitive blood test that indicates when breast cancers become resistant to standard hormone treatment. In addition, the test results can be used to guide further treatment.

New Approach Tackles Hormone Therapy Resistance in Breast Cancer

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Researchers discovered a new explanation for why women with ER+ breast cancer develop resistance to hormone treatment, and a potential new approach that may overcome the problem.

Combination therapy inhibits resistance and recurrence in ovarian cancer

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High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but researchers are investigating why it frequently returns after treatment.

Phase I trial of lung cancer drug identifies multiple types of drug resistance

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Researchers urge for new targeted inhibitors and combinations to combat tumors' constant and varied molecular adaptation.

Changes in cancer epigenome implicated in chemotherapy resistance and lymphoma relapse

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New research indicate that malfunctioning genes are only partly to blame for why treatment that was effective ultimately fails in many patients with the most common form of non-Hodgkin lymphoma.

New lung cancer drugs show promise in advanced disease

New lung cancer drugs show promise in advanced disease

Two experimental medications target mutation that fuels treatment resistance in lung cancer.

Potential chemoresistance after consuming fatty acid in fish and fish oil

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Experiments in mice suggest that elevated blood levels of the fatty acid derived from fish oil may induce resistance to chemotherapy.

Macrophages may play critical role in melanoma resistance to BRAF inhibitors

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Investigators have discovered one way in which melanoma becomes resistant to a particular form of targeted therapy, a discovery that may lead to a new melanoma target or prompt new designs for treatment.

New opportunity to treat drug-resistant leukemia discovered

New opportunity to treat drug-resistant leukemia discovered

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A previously unrecognized action as a potent inhibitor of the dominant mutation that confers drug resistance to all well-tolerated treatments in patients with certain leukemia types has been found in Axitinib.

New mechanism of acquired resistance to breast cancer drugs discovered

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Researchers have discovered that ERBB4 (also known as HER4) is a driver protein in ERBB2-positive tumors that have developed resistance to first- or second-line treatments.

Potentially targetable signaling pathway generates chemotherapy-resistant cancer cells

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Current research has identified a signaling pathway responsible for the generation of slowly proliferating cancer cells that are hard to eradicate via current treatments.

New strategy proposed to overcome treatment resistance in prostate cancer

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Researchers have identified two genes that appear to be simultaneously overexpressed in aggressive prostate cancers resistant to the androgen-targeted treatments enzalutamide and abiraterone acetate.

Research uncovers mechanism of melanoma resistance to newly approved drug combination therapy

Research uncovers mechanism of melanoma resistance to newly approved drug combination therapy

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Researchers have uncovered how melanoma becomes resistant to a promising new drug combination utilizing BRAF+MEK inhibitors after an initial period of tumor shrinkage.

Researchers map paths to cancer drug resistance

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The researchers have mapped the steps used by cells of melanoma, breast cancer, and the blood cancer myelofibrosis to become resistant to drugs, allowing for better success in blocking these pathways and further enabling therapies.

Dramatic response and resistance to cancer drug traced to unsuspected mutations

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Examination of the DNA of a thyroid cancer survivor has revealed details about resistance to the drug everolimus, according to researchers.

IMPRESS trial fails to find benefit from more tyrosine kinase inhibitor (TKI) treatment after resistance develops

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Patients with lung cancer that have developed resistance to the drug gefitinib experience no statistically significant improvement in progression-free survival when continued use of the drug with chemotherapy is utilized.

Rational drug combinations may overcome ibrutinib resistance

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Genomic analyses of tumor and healthy tissue from patients with mantle cell lymphomas provided explanations for two types of resistance to ibrutinib and suggested ways to overcome them.

Breakthrough identifies genes for resistance to MEK inhibitors in colorectal cancer

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A research team has discovered how two genes cause colorectal cancer cells to become resistant to treatments used against the disease.

Exposure to dim light at night may lead to tamoxifen resistance in breast cancer

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For rats bearing human breast tumors, exposure to dim light at night made the tumors resistant to the breast cancer drug tamoxifen, according to recently published data.

New analysis method finds possible therapeutic targets for drug resistant melanoma

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Researchers have developed a new way to identify possible therapeutic targets for patients with drug resistant melanoma.

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