Drug Information

Lorazepam Plus Haloperidol Improves Agitation in Cancer-Related Delirium

Lorazepam Plus Haloperidol Improves Agitation in Cancer-Related Delirium

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A double-blind study compared the effectiveness of lorazepam plus haloperidol with haloperidol alone in reducing agitation in patients with advanced cancer.

Treating Intractable Hiccups in Advanced Cancer, Palliative Care Setting

Treating Intractable Hiccups in Advanced Cancer, Palliative Care Setting

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Intractable hiccups can be especially problematic in the advanced cancer and palliative care settings. Dr Thompson, an oncology pharmacist, reviews options for effective medical management of this condition.

FDA Approves Gemtuzumab Ozogamicin for CD-33 Positive Acute Myeloid Leukemia

FDA Approves Gemtuzumab Ozogamicin for CD-33 Positive Acute Myeloid Leukemia

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Gemtuzumab ozogamicin (Mylotarg) was granted US FDA approval for the treatment of relapsed or refractory CD-33 positive AML in patients ages 2 years and older and newly diagnosed CD-33 positive AML in adult patients.

Median Cost of Cancer Drug Development is Approximately $648 Million

Median Cost of Cancer Drug Development is Approximately $648 Million

Total revenue from sales of 10 drugs was 67.0 billion, with total RD spending of 7.2 billion, researchers found.

Arthritis Medication Shows Potential in the Treatment of Polycythemia Vera

Arthritis Medication Shows Potential in the Treatment of Polycythemia Vera

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Methotrexate, a medication used commonly in the treatment of arthritis, shows promise as a treatment for polycythemia vera, a blood cancer classified as a myeloproliferative neoplasm.

FDA Grants Approval to Idhifa for Some Patients With Acute Myeloid Leukemia

FDA Grants Approval to Idhifa for Some Patients With Acute Myeloid Leukemia

For adults with relapsed or refractory AML who have an IDH2 genetic mutation

Inotuzumab Ozogamicin Granted FDA Approval for Acute Lymphoblastic Leukemia

Inotuzumab Ozogamicin Granted FDA Approval for Acute Lymphoblastic Leukemia

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Inotuzumab ozogamicin (Besponsa), an antibody-drug conjugate comprised of a monoclonal antibody that targets CD22 linked to the cytotoxic agent calicheamicin, was granted FDA approval for the treatment of R/R B-cell precursor ALL.

Opioid Use Higher Among Cancer Survivors, Even After Long-Term Survivorship

Opioid Use Higher Among Cancer Survivors, Even After Long-Term Survivorship

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Rates of opioid prescription use is higher among patients with cancer compared with patients who have never had cancer, even after survivorship.

FDA Expands Ipilimumab Indication to Include Pediatric Unresectable or Metastatic Melanoma

FDA Expands Ipilimumab Indication to Include Pediatric Unresectable or Metastatic Melanoma

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The FDA approved the indication expansion for ipilimumab based on evidence from 2 clinical trials evaluating its safety and efficacy in pediatric patients.

Savolitinib Active, Tolerable in Subset of Advanced Papillary Renal Cell Cancer

Savolitinib Active, Tolerable in Subset of Advanced Papillary Renal Cell Cancer

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Results of a phase 2 clinical trial of savolitinib, a highly selective small molecule inhibitor of c-Met, found the agent was active and tolerable in patients with Met-driven advanced or metastatic papillary renal cell carcinoma (PRCC).

Doxorubicin Efficacy Improved, Cardiotoxicity Reduced With Adjuvant Fidarest for Colon Cancer

Doxorubicin Efficacy Improved, Cardiotoxicity Reduced With Adjuvant Fidarest for Colon Cancer

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The AR inhibitor fidarestat is effective as adjuvant therapy to enhance doxorubicin sensitivity of colorectal cancer cells and to reduce cardiotoxicity associated with the drug.

New Study Questions Standard Dosage for Treating Metastatic Non-Small Cell Lung Cancer

New Study Questions Standard Dosage for Treating Metastatic Non-Small Cell Lung Cancer

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Doses May Be Adjusted for Treating NSCLC Patients

Efficacy of Trastuzumab Biosimilars Shown Equivalent to Originator in HER2 Breast Cancer

Efficacy of Trastuzumab Biosimilars Shown Equivalent to Originator in HER2 Breast Cancer

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Biosimilars and originator trastuzumab neoadjuvant therapy had a comparable effect on pathologic complete response rates.

New Safety Concerns in One-Third of FDA-Approved Drugs 3 Years After Approval

New Safety Concerns in One-Third of FDA-Approved Drugs 3 Years After Approval

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New safety issues are detected in almost one-third of drugs approved by the US FDA in the first 3 years after approval.

Research Shows Temozolomide Has Potential to Increase Depression

Research Shows Temozolomide Has Potential to Increase Depression

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Temozolomide, an antimitotic chemotherapy used to treat brain cancer, demonstrated the potential to increase depression in a mouse model.

New Closed System Drug Transfer Device Can Reduce Nurse Exposure to Antineoplastic Hazardous Drugs

New Closed System Drug Transfer Device Can Reduce Nurse Exposure to Antineoplastic Hazardous Drugs

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A new CSTD significantly reduced surface contamination during a simulated antineoplastic hazardous drug administration when compared to baseline.

Rolapitant Eases CINV in Patients Receiving Highly, Moderately Emetogenic Chemotherapy

Rolapitant Eases CINV in Patients Receiving Highly, Moderately Emetogenic Chemotherapy

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Long-acting NK-1 receptor antagonist rolapitant demonstrates significant efficacy in managing CINV in patients receiving HEC or MEC for cancer.

Durable Response Seen in Advanced HCC With Nivolumab

Durable Response Seen in Advanced HCC With Nivolumab

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New data presented at the International Liver Congress 2017 suggest that nivolumab may produce long-term benefits in sorafenib-experienced patients with advanced HCC.

Carvedilol, Some Beta Blockers Prevent UVB-induced Skin Cancer

Carvedilol, Some Beta Blockers Prevent UVB-induced Skin Cancer

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A common beta blocker, carvedilol, is found to have preventive properties against the sun-induced cell damage that leads to skin cancer.

Rubraca Granted Accelerated FDA Approval for Advanced BRCA-positive Ovarian Cancer

Rubraca Granted Accelerated FDA Approval for Advanced BRCA-positive Ovarian Cancer

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Rubraca (rucaparib) received accelerated approval by the U.S. Food and Drug Administration for the treatment of patients with previously treated BRCA-positive ovarian cancer.

Immunosuppressor Inhibits Metabolic Pathway in Breast Cancer, Kills Cancer Cells

Immunosuppressor Inhibits Metabolic Pathway in Breast Cancer, Kills Cancer Cells

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Leflunomide, an immunosuppressor FDA-approved for rheumatoid arthritis, is effective against breast cancer in mouse study.

ASCO Issues Adjuvant Bisphosphonate in Breast Cancer Guideline

ASCO Issues Adjuvant Bisphosphonate in Breast Cancer Guideline

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Zoledronic acid and clodranate are the recommended bisphosphonates for the adjuvant treatment of postmenopausal patients with breast cancer.

Letermovir Reduces CMV Infection, Improves Survival After Stem Cell Transplantation

Letermovir Reduces CMV Infection, Improves Survival After Stem Cell Transplantation

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A novel agent, letermovir, reduced incidence of CMV in patients undergoing stem cell transplantation for hematologic malignancies.

Patients with Lung Cancer Do Not Benefit from Statins

Patients with Lung Cancer Do Not Benefit from Statins

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Statins provide no benefits, or adverse effects, in patients with lung cancer, according to a phase 3 trial.

Kinase Inhibitors: Managing Adverse Effects in the Treatment of Metastatic Melanoma

Kinase Inhibitors: Managing Adverse Effects in the Treatment of Metastatic Melanoma

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Despite their efficacy in metastatic melanoma, KIs include risk of serious side effects in patients. This overview explains the effects and management recommendations for 4 agents used to treat metastatic melanoma.

Antidiabetes Drug Holds Promise as Adjuvant Therapy for Older Patients with Melanoma

Antidiabetes Drug Holds Promise as Adjuvant Therapy for Older Patients with Melanoma

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Rosiglitazone has potential for older patients with melanoma who develop resistance to targeted therapies.

Pediatric Patients, Parents Overreport Adherence to ALL Medication Regimen

Pediatric Patients, Parents Overreport Adherence to ALL Medication Regimen

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Pediatric patients and their parents tend to overestimate adherence to anticancer medicine regimen.

Arsenic and APL: Review of Therapy for an Acute Leukemia

Arsenic and APL: Review of Therapy for an Acute Leukemia

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I was surprised to see an order for arsenic recently. What is this being used for?

Escalating Drug Prices Central to Value Discussion of Cancer Treatment Regimens

Escalating Drug Prices Central to Value Discussion of Cancer Treatment Regimens

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In his plenary lecture at 2016 SABCS, Peter P. Bach, MD, MAPP, reviewed the factors contributing to escalating drug prices and the significance of drug prices in the value of a cancer treatment regimen.

Rucaparib Monotherapy Approved for Advanced Ovarian Cancer

Rucaparib Monotherapy Approved for Advanced Ovarian Cancer

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Rucaparib has been approved for the treatment of patients with advanced ovarian cancer who harbor a deleterious BRCA mutation.

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