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Doxepin HCl Concentrate
Anxiety/OCD
Mood disorders
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Drug Name:

Doxepin HCl Concentrate Rx

Generic Name and Formulations:
Doxepin (as HCl) 10mg/mL.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Doxepin HCl Concentrate:

Anxiety.

Adult:

Soln: dilute with 4oz juice, water, or milk. Mild: 25–50mg/day. Mild-to-moderate: initially 75mg/day; range 75–150mg/day. Severe: max 300mg/day. May give as single (up to 150mg) or divided doses; 150mg caps for maintenance only.

Children:

Not recommended.

Contraindications:

Urinary retention. Glaucoma.

Warnings/Precautions:

Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. Screen for bipolar disorder. Cardiovascular disease. Angle-closure glaucoma. Seizures. Psychosis. Poor metabolizers (those with reduced CYP2D6 activity). Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly. Pregnancy. Nursing mothers.

Interactions:

Hyperpyretic crisis, convulsions, death with MAOIs; discontinue at least 14 days prior to initiating doxepin. Potentiated by CYP2D6 inhibitors (eg, quinidine, cimetidine, phenothiazines, SSRIs, Type IC antiarrhythmics); may need dose reduction. Do not initiate within 5 weeks of discontinuing fluoxetine. Avoid alcohol. May block guanethidine.

See Also:

Doxepin HCl Capsules

Pharmacological Class:

Tricyclic.

Adverse Reactions:

CNS effects (eg, drowsiness, overstimulation, extrapyramidal symptoms), anticholinergic effects, hypotension, GI upset, photosensitivity, endocrine effects.

Note:

Formerly known under the brand name Sinequan.

How Supplied:

Contact supplier.

Indications for Doxepin HCl Concentrate:

Depression.

Adult:

Soln: dilute with 4oz juice, water, or milk. Mild: 25–50mg/day. Mild-to-moderate: initially 75mg/day; range 75–150mg/day. Severe: max 300mg/day. May give as single (up to 150mg) or divided doses; 150mg caps for maintenance only.

Children:

Not recommended.

Contraindications:

Urinary retention. Glaucoma.

Warnings/Precautions:

Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening and unusual changes. Screen for bipolar disorder. Cardiovascular disease. Angle-closure glaucoma. Seizures. Psychosis. Poor metabolizers (those with reduced CYP2D6 activity). Avoid abrupt cessation. Write ℞ for smallest practical amount. Elderly. Pregnancy. Nursing mothers.

Interactions:

Hyperpyretic crisis, convulsions, death with MAOIs; discontinue at least 14 days prior to initiating doxepin. Potentiated by CYP2D6 inhibitors (eg, quinidine, cimetidine, phenothiazines, SSRIs, Type IC antiarrhythmics); may need dose reduction. Do not initiate within 5 weeks of discontinuing fluoxetine. Avoid alcohol. May block guanethidine.

See Also:

Doxepin HCl Capsules

Pharmacological Class:

Tricyclic.

Adverse Reactions:

CNS effects (eg, drowsiness, overstimulation, extrapyramidal symptoms), anticholinergic effects, hypotension, GI upset, photosensitivity, endocrine effects.

Note:

Formerly known under the brand name Sinequan.

How Supplied:

Contact supplier.

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