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DORYX MPC
Acne
Bacterial infections
Malaria
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Drug Name:

DORYX MPC Rx

Generic Name and Formulations:
Doxycycline (as hyclate) 60mg, 120mg; del-rel tabs; contains sodium.

Company:
Mayne Pharma US

Therapeutic Use:

Indications for DORYX MPC:

Adjunct in severe acne.

Adult:

Do not substitute on a mg-per-mg basis with other oral doxycyclines. Swallow whole. Take with fluids. 120mg every 12hrs for 1 day, then 120mg daily in 1–2 divided doses. Reduce dose after improvement.

Children:

Not applicable.

Warnings/Precautions:

Children ≤8yrs: weigh benefits vs. risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Discontinue if skin erythema, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Avoid sunlight or UV light. Monitor blood, renal, and hepatic function in long-term use. Pregnancy. Nursing mothers.

Interactions:

Antacids, aluminum, iron, calcium, magnesium, bismuth subsalicylate reduce absorption. Avoid concomitant penicillins, methoxyflurane, isotretinoin. Carbamazepine, barbiturates, hydantoins decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective. May interfere with fluorometric detection of urinary catecholamines.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, dysphagia, enterocolitis, pancreatitis, skin rashes (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

NO

How Supplied:

Tabs 60mg—120; 120mg—60

Indications for DORYX MPC:

Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma, specific bacterial (eg, relapsing fever). Alternative for selected infections when penicillin is contraindicated. Anthrax including inhalational anthrax (postexposure).

Adult:

Do not substitute on a mg-per-mg basis with other oral doxycyclines. Swallow whole. Take with fluids. 120mg every 12hrs for 1 day; then 120mg daily; if severe: 120mg every 12hrs. Streptococcal infections: continue for 10 days. Uncomplicated urethral, endocervical, or rectal: 120mg twice daily for 7 days. Uncomplicated gonococcal: 120mg twice daily for 7 days or as an alternative single visit dose: 360mg stat, followed in one hr by a second 360mg dose. Nongonococcal urethritis: 120mg twice daily for 7 days. Early syphilis: (allergic to penicillin): 120mg twice daily for 2 weeks; syphilis >1 year's duration: treat for 4 weeks. Acute epididymo-orchitis: 120mg twice daily for at least 10 days. Postexposure inhalational anthrax: 120mg twice daily for 60 days (start as soon as possible after exposure).

Children:

<8yrs: not usually recommended. Do not substitute on a mg-per-mg basis with other oral doxycyclines. Swallow whole. Take with fluids. ≥8yrs: Severe/life-threatening infections: (<45kg): 2.6mg/kg every 12hrs; (≥45kg): give adult dose. Less severe infections: (<45kg): 5.3mg/kg in 2 divided doses for 1 day, then 2.6mg/kg in 1–2 divided doses; (≥45kg): give adult dose. Postexposure inhalational anthrax: (<45kg): 2.6mg/kg twice daily for 60 days; (≥45kg): give adult dose.

Warnings/Precautions:

Children ≤8yrs: weigh benefits vs. risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Discontinue if skin erythema, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Avoid sunlight or UV light. Monitor blood, renal, and hepatic function in long-term use. Pregnancy. Nursing mothers.

Interactions:

Antacids, aluminum, iron, calcium, magnesium, bismuth subsalicylate reduce absorption. Avoid concomitant penicillins, methoxyflurane, isotretinoin. Carbamazepine, barbiturates, hydantoins decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective. May interfere with fluorometric detection of urinary catecholamines.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, dysphagia, enterocolitis, pancreatitis, skin rashes (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

NO

How Supplied:

Tabs 60mg—120; 120mg—60

Indications for DORYX MPC:

Short term prophylaxis of malaria due to P. falciparum.

Adult:

Do not substitute on a mg-per-mg basis with other oral doxycyclines. Swallow whole. Take with fluids. Begin 1–2 days before travel to the malarious area, continue during and 4 weeks after leaving the area. 120mg daily.

Children:

<8yrs: not recommended. Do not substitute on a mg-per-mg basis with other oral doxycyclines. Swallow whole. Take with fluids. Begin 1–2 days before travel to the malarious area, continue during and 4 weeks after leaving the area. ≥8yrs (<45kg): 2.4mg/kg once daily; (≥45kg): use adult dose.

Warnings/Precautions:

Children ≤8yrs: weigh benefits vs. risks; reserve use only for severe or life-threatening conditions (eg, anthrax, Rocky Mountain spotted fever) when no alternative therapies exist. Discontinue if skin erythema, superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Avoid sunlight or UV light. Monitor blood, renal, and hepatic function in long-term use. Pregnancy. Nursing mothers.

Interactions:

Antacids, aluminum, iron, calcium, magnesium, bismuth subsalicylate reduce absorption. Avoid concomitant penicillins, methoxyflurane, isotretinoin. Carbamazepine, barbiturates, hydantoins decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective. May interfere with fluorometric detection of urinary catecholamines.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, dysphagia, enterocolitis, pancreatitis, skin rashes (may be severe), photosensitivity, urticaria, hemolytic anemia; teeth discoloration, intracranial hypertension, C.difficile-associated diarrhea, increased BUN.

Generic Availability:

NO

How Supplied:

Tabs 60mg—120; 120mg—60

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