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Diphenoxylate HCl/Atropine Sulfate Oral Solution
Diarrhea
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Drug Name:

Diphenoxylate HCl/Atropine Sulfate Oral Solution CV

Generic Name and Formulations:
Diphenoxylate HCl 2.5mg, atropine sulfate 0.025mg; per 5mL liq; alcohol 15%.

Company:
Roxane Laboratories, Inc.

Therapeutic Use:

Indications for Diphenoxylate HCl/Atropine Sulfate Oral Solution:

Adjunct to fluid and electrolyte replacement in diarrhea.

Adult:

2 tabs or 10mL 4 times daily until diarrhea is controlled. Maintenance: 2 tabs or 10mL daily.

Children:

<2yrs: not recommended. 2–12yrs: initially 0.3–0.4mg/kg in 4 divided doses until diarrhea is controlled. Maintenance: 25% initial dose; max 48hrs.

Contraindications:

Pseudomembranous enterocolitis. Obstructive jaundice. Diarrhea caused by organisms that penetrate intestinal mucosa. Age <2yrs.

Warnings/Precautions:

Dehydration. Acute ulcerative colitis; discontinue if toxic megacolon occurs. Hepatic or renal disease. Abnormal liver function tests. Drug abusers. Pregnancy (Cat.C). Nursing mothers.

Interactions:

MAOIs may cause hypertensive crisis. Antimuscarinics may cause paralytic ileus. Potentiates sedation with alcohol, CNS depressants. May delay elimination of other drugs metabolized by CYP450.

See Also:

LOMOTIL

Pharmacological Class:

Opioid + anticholinergic.

Adverse Reactions:

Nausea, vomiting, abdominal discomfort, paralytic ileus, toxic megacolon, dizziness, drowsiness, headache, euphoria, tachycardia, numbness of extremities, pruritus, urticaria, angioneurotic edema, anticholinergic effects; respiratory depression (overdosage), atropinism.

How Supplied:

Tabs—100, 500, 1000, 2500; Soln—60mL

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