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DILATRATE-SR
Angina
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Drug Name:

DILATRATE-SR Rx

Generic Name and Formulations:
Isosorbide dinitrate 40mg; sust-rel caps.

Company:
Endo Pharmaceuticals

Therapeutic Use:

Indications for DILATRATE-SR:

Prophylaxis and treatment of angina. Not for acute attacks.

Adult:

See full labeling. Allow at least an 18-hour interval daily between doses to avoid development of tolerance. Max 160mg/day.

Children:

Not established.

Contraindications:

Concomitant PDE inhibitors (eg, sildenafil, tadalafil, vardenafil, avanafil) or riociguat.

Warnings/Precautions:

Recent MI. CHF. Volume depletion. Hypotension. Hypertrophic cardiomyopathy. Monitor standing blood pressure when increasing doses. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Hypotension potentiated with alcohol, other vasodilators.

Pharmacological Class:

Nitrate.

Adverse Reactions:

Headache, transient lightheadedness, orthostatic hypotension; rare: syncope, angina, rebound hypertension.

How Supplied:

Caps—100

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