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Diflunisal
Arthritis/rheumatic disorders
Nonnarcotic analgesics
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Drug Name:

Diflunisal Rx

Generic Name and Formulations:
Diflunisal 250mg, 500mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Diflunisal:

Osteoarthritis. Rheumatoid arthritis.

Adult:

250–500mg twice daily; max 1.5g/day.

Children:

Not recommended.

Contraindications:

Aspirin allergy. Varicella or influenza in teenagers. 3rd trimester pregnancy. Coronary artery bypass graft surgery.

Warnings/Precautions:

Advanced renal disease: not recommended. Active peptic ulcer or GI bleeding. History of GI disease. Cardiac failure. Hypertension. Impaired renal or hepatic function. Volume depletion. Bleeding disorders. Sepsis. Diabetes. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C in 1st and 2nd trimesters). Nursing mothers: not recommended.

Interactions:

Avoid methotrexate, indomethacin. Oral anticoagulants potentiated. Increased acetaminophen and hydrochlorothiazide serum levels. Reduced absorption with antacids.

Pharmacological Class:

Salicylate.

Adverse Reactions:

Peptic ulcer, GI bleeding, nausea, dyspepsia, GI pain, diarrhea, rash (discontinue if occurs), headache, dizziness, edema, nephritis. See literature re: risk of cardiovascular disease.

Note:

Formerly known under the brand name Dolobid.

How Supplied:

Contact supplier.

Indications for Diflunisal:

Mild to moderate pain.

Adult:

0.5–1g once then 250–500mg every 8–12 hrs.

Children:

Not recommended.

Contraindications:

Aspirin allergy. Varicella or influenza in teenagers. 3rd trimester pregnancy. Coronary artery bypass graft surgery.

Warnings/Precautions:

Advanced renal disease: not recommended. Active peptic ulcer or GI bleeding. History of GI disease. Cardiac failure. Hypertension. Impaired renal or hepatic function. Volume depletion. Bleeding disorders. Sepsis. Diabetes. Monitor blood, hepatic, renal, and ocular function in chronic use. Elderly. Debilitated. Pregnancy (Cat.C in 1st and 2nd trimesters). Nursing mothers: not recommended.

Interactions:

Avoid methotrexate, indomethacin. Oral anticoagulants potentiated. Increased acetaminophen and hydrochlorothiazide serum levels. Reduced absorption with antacids.

Pharmacological Class:

Salicylate.

Adverse Reactions:

Peptic ulcer, GI bleeding, nausea, dyspepsia, GI pain, diarrhea, rash (discontinue if occurs), headache, dizziness, edema, nephritis. See literature re: risk of cardiovascular disease.

Note:

Formerly known under the brand name Dolobid.

How Supplied:

Contact supplier.

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