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DIFLUCAN 150mg
Vaginal infections
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Drug Name:

DIFLUCAN 150mg Rx

Generic Name and Formulations:
Fluconazole 150mg; tabs.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for DIFLUCAN 150mg:

Vaginal candidiasis.

Adult:

150mg orally once.

Children:

Not recommended.

Contraindications:

Concomitant terfenadine at multiple doses of fluconazole ≥400mg. Concomitant drugs known to prolong the QT interval and metabolized by CYP3A4 (eg, cisapride, astemizole, erythromycin, pimozide, quinidine).

Warnings/Precautions:

Proarrhythmic conditions. Renal or hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Risk of cardiotoxicity with erythromycin; avoid. Avoid concomitant voriconazole; if needed, monitor closely esp. when given within 24hrs after fluconazole. Potentiates warfarin, oral hypoglycemics, oral midazolam, tofacitinib, alfentanil, amitriptyline, nortriptyline, calcium channel blockers, losartan, saquinavir; adjust dose as necessary. May increase serum levels of phenytoin, theophylline, halofantrine, rifabutin, tacrolimus, sirolimus, vinca alkaloids, triazolam, methadone, NSAIDs, cyclosporine, zidovudine, sulfonylureas, carbamazepine. Concomitant celecoxib: reduce celecoxib dose by half. Thiazides increase fluconazole levels. Monitor levels and/or effects of cyclosporine, phenytoin, sulfonylureas, rifabutin, tacrolimus, theophylline, warfarin, prednisone. Increased risk of myopathy/rhabdomyolysis with concomitant HMG-CoA reductase inhibitors; closely monitor. Cimetidine (oral), rifampin may decrease fluconazole levels. Oral contraceptives: see full labeling. Avoid other hepatotoxic drugs. Caution with other drugs metabolized by CYP2C9 and CYP3A4 with a narrow therapeutic window.

Pharmacological Class:

Azole antifungal.

Adverse Reactions:

Nausea, headache, rash, vomiting, abdominal pain, diarrhea, dizziness, seizures; hepatotoxicity; rare: exfoliative dermatitis, QT prolongation, Torsade de pointes.

How Supplied:

Tabs—1

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