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DICLEGIS
Nausea
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Drug Name:

DICLEGIS Rx

Generic Name and Formulations:
Doxylamine succinate 10mg, pyridoxine HCl 10mg; delayed-release tablets.

Company:
Duchesnay USA, Inc.

Therapeutic Use:

Indications for DICLEGIS:

Treatment of nausea and vomiting of pregnancy (NVP) in women who do not respond to conservative management. Limitations of use: has not been studied in women with hyperemesis gravidarum.

Adult:

Swallow whole. Take on empty stomach with water. Day 1: initially 2 tabs at bedtime; continue same dose next day if symptoms adequately controlled. If symptoms persist into afternoon of Day 2, take usual dose of 2 tabs at bedtime that night, and then starting on Day 3 take 3 tabs (1 tablet in AM and 2 tabs at bedtime); continue if symptoms adequately controlled. If symptoms persist, starting on Day 4 take 4 tabs (1 tab in the AM, 1 tab mid-afternoon, and 2 tabs at bedtime). Max 4 tabs daily.

Children:

<18yrs: not established.

Contraindications:

Concomitant MAOIs; may prolong and intensify anticholinergic effects.

Warnings/Precautions:

Asthma. Increased intraocular pressure. Narrow angle glaucoma. Stenosing peptic ulcer. Pyloroduodenal obstruction. Urinary bladder-neck obstruction. Reassess for continued need of treatment as pregnancy progresses. Pregnancy (Cat.A). Nursing mothers: not recommended.

Interactions:

See Contraindications. Concomitant alcohol, other CNS depressants (eg, hypnotic sedatives, tranquilizers): not recommended. Concomitant food may delay onset of action and reduce absorption.

Pharmacological Class:

Antihistamine + Vit. B6 analog.

Adverse Reactions:

Somnolence, severe drowsiness, falls, other accidents.

How Supplied:

Tabs—100

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