Diagnostic Tests

Breath Analysis May Be an Effective Diagnostic for Pancreatic Cancer

Breath Analysis May Be an Effective Diagnostic for Pancreatic Cancer

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Seeking to determine if breath tests could be used to diagnose pancreatic cancer, researchers identified breath volatile organic compounds (VOCs) that may indicate presence of the disease.

Lung Cancer Screening More Efficient for Those at Higher Risk

Lung Cancer Screening More Efficient for Those at Higher Risk

Initial screens were least effective and least efficient for veterans with lowest lung cancer risk, according to this study.

Liquid Biopsies: An Emerging and Versatile Monitoring Modality in Lung Cancer

Liquid Biopsies: An Emerging and Versatile Monitoring Modality in Lung Cancer

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In lung cancer, it is critical to evaluate the resistance mechanisms so appropriate treatment can be administered.

Intermediate Oncotype DX Scores Prognostic of OS in Early-stage Breast Cancer

Intermediate Oncotype DX Scores Prognostic of OS in Early-stage Breast Cancer

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Study findings presented at SABCS 2017 demonstrate that intermediate Oncotype DX scores are prognostic of overall survival for patients with early-stage breast cancer, particularly in younger women with the disease.

Flow Cytometry Assesses Minimal Residual Disease in Multiple Myeloma

Flow Cytometry Assesses Minimal Residual Disease in Multiple Myeloma

The use of flow cytometry has demonstrated usefulness in multiple myeloma recurrence assessment.

Handheld Endoscopic Probe Set to Improve Cancer Diagnosis

Handheld Endoscopic Probe Set to Improve Cancer Diagnosis

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An endoscopic imaging tool in development could aid diagnosis of cancer without the delay of pathologic review of tissue sampling and staining.

Novel Test For Multiple Myeloma Uses Microchip, Conventional Blood Sample

Novel Test For Multiple Myeloma Uses Microchip, Conventional Blood Sample

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MIT team develops simple, less painful diagnostic test for multiple myeloma using microfluidic chip and conventional blood sample.

Noninvasive 2-Gene Test Helps Distinguish Melanoma From Nonmelanoma

Noninvasive 2-Gene Test Helps Distinguish Melanoma From Nonmelanoma

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Two-gene pigmented lesion test classifies skin lesions as melanoma or nonmelanoma, helping with diagnostic challenges faced with the visual image and pattern recognition approach.

Novel Blood Test Pinpoints Cancer Without Invasive Procedures

Novel Blood Test Pinpoints Cancer Without Invasive Procedures

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A new blood test employs a type of DNA signature to locate the presence of tumor in a particular tissue, avoiding the need for invasive diagnostic procedures.

Nasal Biomarker in Smokers Could Predict Lung Cancer

Nasal Biomarker in Smokers Could Predict Lung Cancer

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Novel diagnostic test determines whether suspicious lung lesions or nodules are malignant disease from a sample obtained via nasal swab.

Patient, Physician Preferences Inform Guidelines for Discussing Molecular Testing in Cancer Treatment

Patient, Physician Preferences Inform Guidelines for Discussing Molecular Testing in Cancer Treatment

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Study identifies physician and patient preferences about information, who should communicate this information, and what guidelines should guide these discussions.

Breath Test Might Assist Detection of Stomach and Esophageal Cancers

Breath Test Might Assist Detection of Stomach and Esophageal Cancers

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Research presented at the 2017 European Cancer Congress describes the potential of a noninvasive diagnostic test for esophageal and gastric cancers that measures chemicals in the breath.

Focus on Treatment Options Diminishes Patients' Understanding of Poor Prognosis

Focus on Treatment Options Diminishes Patients' Understanding of Poor Prognosis

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The simple question: "Would you like to talk about what this means?" can lead to more thorough discussions about scan results and prognoses, better preparing patients to make informed treatment decisions.

Computer 'Deep Learning' Algorithm Matches Dermatologists at Classifying Melanomas

Computer 'Deep Learning' Algorithm Matches Dermatologists at Classifying Melanomas

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Researchers compared the ability of an artificial-intelligence algorithm to recognize and classify skin cancers with the clinical evaluations of dermatologists.

Pathology Reports (Fact Sheet)

Pathology Reports (Fact Sheet)

This fact sheet examines pathology reports, including tissue collection methods, the ways in which tissue samples may be processed, and details typically included in such reports.

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

Recurrence Score Appears To Be Driving Personalized Treatment for Breast Cancer

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The recurrence score assay stratifies early stage, estrogen receptor-positive breast cancer by recurrence risk. This study assessed how clinicians use the recurrence score to recommend adjuvant systemic therapy or patients' experiences with testing decision-making.

Epigenetic Profiling Improves Identification of Primary Tumor in CUP

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DNA methylation profiling identified the primary cancer in cases of cancer of unknown primary, informing tumor-type specific treatment that improved overall survival in these patients.

Ratio of Biomarkers on Imaging Identifies Aggressiveness of DCIS

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A new technique combines imaging and mathematics to identify aggressive forms of ductal carcinoma in situ (DCIS), or stage 0 breast cancer, from nonaggressive varieties.

Computer Algorithm Matches Skilled Specialists in Detecting Early Esophageal Cancer

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Using a computer algorithm to scan images of the esophagus for signs of early esophageal cancer is nearly as accurate as top specialists.

PET/CT Hybrid Imaging Technique Provides Accurate Guide for Prostate Cancer Biopsy

PET/CT Hybrid Imaging Technique Provides Accurate Guide for Prostate Cancer Biopsy

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Prostate-specific molecular imaging at initial biopsy and preoperative planning can accurately determine and delineate the extent of prostate cancer. The imaging technique was a type of PET/CT called 68Ga-PSMA PET/CT.

Lung Cancer Signature Detected Via Breath Test Improves Early Diagnosis

Lung Cancer Signature Detected Via Breath Test Improves Early Diagnosis

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Breath analysis offers an option for both primary screening and postsurgery monitoring of patients with lung cancer. Exhaled breath has certain carbonyl VOCs that indicate the presence of lung cancer in a process researchers hope will receive FDA approval.

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

New WHO Glioma Classification Can 'Optimize Patient Treatment Going Forward'

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The 2016 WHO Classification of Infiltrating Gliomas alters diagnostic criteria, providing the basis for clinical trial inclusion or exclusion based on an integrated diagnosis and setting the stage for all future research, according to a summary of 4 posters related to CNS biomarkers presented at the ASCO 2016 Annual Meeting.

Nuclear Imaging Offers Noninvasive Assessment of Early Stage Cervical Cancer

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In patients with cervical cancer who do not have enlarged lymph nodes, SPECT-MRI imaging of their sentinel lymph nodes (SLNs) could assess whether metastases are present.

Urine Test Accurately Identifies Tumor Grade in Prostate Cancer

Urine Test Accurately Identifies Tumor Grade in Prostate Cancer

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A new urine assay that can detect genetic changes correlated with prostate cancer correctly identified cancer grade in 92% of men with elevated PSA levels and high-grade cancers.

Altered Metabolism of Four Compounds Drives Glioblastoma Growth

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The altered metabolism of methionine, tryptophan, kynurenine, and 5-methylthioadenosine can drive the development of glioblastoma. Results also suggest ways to treat the cancer, slow its growth, and precisely elucidate its extent.

Pill Improves Breast Imaging to Light Up Cancer

Pill Improves Breast Imaging to Light Up Cancer

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Scientists are developing a pill that illuminates only cancerous tumors, improving on current methods that can identify tumors but cannot conclusively determine whether they are cancerous

Disparities Related to Race, Insurance, and Facility Type Affect Use of Genetic Assay in Breast Cancer

Disparities Related to Race, Insurance, and Facility Type Affect Use of Genetic Assay in Breast Cancer

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Use and clinical implications of a test commonly used to predict the aggressiveness of early stage ER-positive breast cancer is influenced by patient's race, insurance, and type of facility.

Biomarker Tests Hindered by Lack of Sufficient Evidence and Regulation

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Precision medicine aims to deliver the most appropriate treatment to individual patients; however, biomarker tests that are poorly validated or inappropriately applied could hinder administration of appropriate treatments, and in some cases motivate the use of harmful treatment.

Significant Gap in Sequencing Limits the Potential of Precision Medicine

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Despite improvements in genomic sequencing technologies, a significant number of medically important genes are within genomic regions in which sequencing lacks the technical accuracy to generate reliable reads.

Metabolic Phenotyping of Blood Plasma Enables Lung Cancer Detection

Metabolic Phenotyping of Blood Plasma Enables Lung Cancer Detection

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Unique metabolic biomarkers specific to lung cancer were found through metabolic phenotyping of blood plasma by proton nuclear magnetic resonance (H-NMR), enabling diagnosis of both early-stage and late-stage disease.

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