This fact sheet examines pathology reports, including tissue collection methods, the ways in which tissue samples may be processed, and details typically included in such reports.
The recurrence score assay stratifies early stage, estrogen receptor-positive breast cancer by recurrence risk. This study assessed how clinicians use the recurrence score to recommend adjuvant systemic therapy or patients' experiences with testing decision-making.
DNA methylation profiling identified the primary cancer in cases of cancer of unknown primary, informing tumor-type specific treatment that improved overall survival in these patients.
A new technique combines imaging and mathematics to identify aggressive forms of ductal carcinoma in situ (DCIS), or stage 0 breast cancer, from nonaggressive varieties.
Using a computer algorithm to scan images of the esophagus for signs of early esophageal cancer is nearly as accurate as top specialists.
Prostate-specific molecular imaging at initial biopsy and preoperative planning can accurately determine and delineate the extent of prostate cancer. The imaging technique was a type of PET/CT called 68Ga-PSMA PET/CT.
Breath analysis offers an option for both primary screening and postsurgery monitoring of patients with lung cancer. Exhaled breath has certain carbonyl VOCs that indicate the presence of lung cancer in a process researchers hope will receive FDA approval.
The 2016 WHO Classification of Infiltrating Gliomas alters diagnostic criteria, providing the basis for clinical trial inclusion or exclusion based on an integrated diagnosis and setting the stage for all future research, according to a summary of 4 posters related to CNS biomarkers presented at the ASCO 2016 Annual Meeting.
In patients with cervical cancer who do not have enlarged lymph nodes, SPECT-MRI imaging of their sentinel lymph nodes (SLNs) could assess whether metastases are present.
A new urine assay that can detect genetic changes correlated with prostate cancer correctly identified cancer grade in 92% of men with elevated PSA levels and high-grade cancers.
The altered metabolism of methionine, tryptophan, kynurenine, and 5-methylthioadenosine can drive the development of glioblastoma. Results also suggest ways to treat the cancer, slow its growth, and precisely elucidate its extent.
Scientists are developing a pill that illuminates only cancerous tumors, improving on current methods that can identify tumors but cannot conclusively determine whether they are cancerous
Disparities Related to Race, Insurance, and Facility Type Affect Use of Genetic Assay in Breast CancerApril 01, 2016
Use and clinical implications of a test commonly used to predict the aggressiveness of early stage ER-positive breast cancer is influenced by patient's race, insurance, and type of facility.
Precision medicine aims to deliver the most appropriate treatment to individual patients; however, biomarker tests that are poorly validated or inappropriately applied could hinder administration of appropriate treatments, and in some cases motivate the use of harmful treatment.
Despite improvements in genomic sequencing technologies, a significant number of medically important genes are within genomic regions in which sequencing lacks the technical accuracy to generate reliable reads.
Unique metabolic biomarkers specific to lung cancer were found through metabolic phenotyping of blood plasma by proton nuclear magnetic resonance (H-NMR), enabling diagnosis of both early-stage and late-stage disease.
A new analysis method for magnetic resonance imaging (MRI) data appears to reliably determine whether patients would need hormonal treatment only or also need chemotherapy.
An immunohistochemistry (IHC) test for rearrangements of the gene for anaplastic lymphoma kinase (ALK) receptor performed more accurately than another commonly used IHC assay, including reducing the rate of false positives.
Recent developments in a gas chromatography tool might allow doctors to determine whether urologic cancers are present via a urine sample.
A new technology detects disease biomarkers in the form of nucleic acids, which are the molecules that comprise DNA and RNA. The test zeroes in on microRNA, which can signal a wide range of diseases, including cancer.
Persistent chronic myeloid leukemia in patients previously thought to be in remission can be detected with digital polymerase chain reaction.
Among young women diagnosed with breast cancer, frequency of testing 95 percent in 2013
A recent study fine-tuned the popular Simple Rules ultrasound test for ovarian cancer.
Given to the importance of improved cancer predictors, the American Joint Committee on Cancer (AJCC) has established first-of-its-kind guidelines for the practice of precision medicine.
A program in a multifacility health care system is designed to enhance early detection of lung cancer through follow-up of nodules seen on thoracic imaging studies.
Circulating Tumor DNA More Effective Than LDH at Detecting Metastatic Melanoma Progression, RecurrenceJanuary 25, 2016
Metastatic melanoma disease activity may be monitored via circulating tumor DNA, which has higher sensitivity than lactate dehydrogenase for detecting disease progression.
Novel Diagnostic Test Uses CTCs in Blood to Guide Treatment Decisions for Patients With Prostate CancerJanuary 19, 2016
An experimental liquid biopsy using a blood sample may determine which patients with prostate cancer will benefit from hormone therapies.
A noninvasive, low-cost blood test was developed to help doctors diagnose some types of malignant childhood tumor. It could also enable treatment monitoring without exposing patients to repeated doses of radiation.
Genetic analyses and other tests performed by both researchers and physicians can be significantly skewed when normal cells, especially immune cells, are intermixed with cancerous cells in a tissue sample.
Additional breast cancers found with MRI are sometimes larger and potentially more aggressive than those found on mammography, and in some cases, may necessitate a change in treatment plan.
- Beta-blockers May Improve Survival in Multiple Myeloma
- Preventing Tumor Lysis Syndrome in Patients Receiving Venetoclax
- Thalidomide, Lenalidomide Equivalent With Respect to Survival in Myeloma
- LIVESTRONG Exercise Program Improves QoL in Cancer Survivors
- Rasburicase More Effective Than Allopurinol for Tumor Lysis Syndrome
- Exercise is as Effective in Treating Metastatic Prostate Cancer as Medication
- Walnut Consumption Changes Gut Microbiome, Decreases Growth of Colon Cancer in Mice
- Vaccine Enters Phase I Study for Safety and Effectiveness in Multiple Myeloma
- Study Supports Increased Role for Surgery in Multimodality Therapy for Early Stage SCLC
- Timing Chemotherapy Administration to Circadian Rhythm Improves Drug Effectiveness
- Alternating Pazopanib and Everolimus Treatment Schedule Not Effective for RCC
- Adding Onartuzumab to Chemo Not Effective for HER2-, MET+ Gastroesophageal Adenocarcinoma
- Rasburicase More Effective Than Allopurinol for Tumor Lysis Syndrome
- Mental Health Disorder Linked to Poorer Survival in NSCLC
- Perindopril, Bisoprolol Not Effective for Preventing Trastuzumab-mediated Left Ventricular Remodeling
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