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DEXFERRUM
Anemias
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Drug Name:

DEXFERRUM Rx

Generic Name and Formulations:
Iron (as dextran complex) 50mg/mL; soln for IV inj.

Company:
American Regent, Inc.

Therapeutic Use:

Indications for DEXFERRUM:

Iron deficiency where oral therapy is unsatisfactory or impossible.

Adults and Children:

<4months: not recommended. Give by IV inj. Administer 0.5mL test dose first; if no signs/symptoms of anaphylactic-type reactions, may give full therapeutic dose. ≥4months: Iron deficiency anemia: determine total dose based on hemoglobin and body weight (see literature). Iron replacement for blood loss: Replacement iron (in mg) = blood loss (in mL) X hematocrit. Max daily doses: <5kg: 0.5mL (25mg), <10kg: 1mL (50mg), ≥10kg: 2mL (100mg).

Contraindications:

Anemia not associated with iron deficiency.

Warnings/Precautions:

Monitor for signs/symptoms of anaphylactic-type reactions, esp. in patients with history of allergies, asthma; have epinephrine available. Hepatic impairment. Avoid during acute phase of infectious kidney disease. Cardiovascular disease. Avoid large IV doses: higher incidence of adverse events. Iron overload more likely with hemoglobinopathies or refractory anemias. Rheumatoid arthritis. Neonates. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Concomitant ACE inhibitors may increase the risk for anaphylactic-type reactions. May falsely elevate serum bilirubin and decrease serum calcium.

Pharmacological Class:

Hematinic.

Adverse Reactions:

See full labeling. Anaphylactic reactions (may be fatal, even in patients who tolerated test dose), cardiovascular events, pruritus, GI upset, arthralgia, arthritis, inj site reactions, others.

How Supplied:

Single-dose vials (1mL, 2mL)—10

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