Onchocerciasis (River Blindness)
Are You Confident of the Diagnosis?
What you should be alert for in the history
A clinical suspicion of onchocerciasis or “river blindness” is relevant in travelers returning from endemic areas who have eye symptoms, severe pruritus, and/or a discrete itchy papular rash of the lower extremities. Long-term residents of endemic areas emigrating to nonendemic areas may present with more manifest skin and eye symptoms.
Onchocerciasis is a chronic and slowly progressive disease. The initial infestation often occurs in childhood and many of the affected individuals remain asymptomatic for long periods.
Characteristic findings on physical examination
The skin manifestations of onchocerciasis are highly variable. They include: acute papular onchodermatitis (APOP), which denotes an eczematous rash with multiple small widely scattered pruritic papules (
Acute papular onchodermatitis.
Chronic papular onchodermatitis (CPOD) is a maculopapular rash containing scattered flat-topped papules of variable size, often accompanied by pruritus and postinflammatory hyperpigmentation, typically affecting shoulders, buttocks, and extremities, including the wrists (
Chronic papular onchodermatitis.
Lichenified onchodermatitis (LOD) consists of hyperkeratotic and hyperpigmented confluent plaques, most often affecting the lower extremities and associated with lymphadenopathy.
Onchocercal atrophy (ATR) consists of large atrophic plaques with finely wrinkled inelastic skin resembling cigarette paper, typically affecting the buttocks and the lower back (
Onchocercal depigmentation (DPM) or “leopard skin” consists of vitiligo-like lesions with hypopigmented patches containing perifollicular spots of normally pigmented skin (
Onchocercal depigmentation ("leopard skin")
Palpable onchocercal nodules are asymptomatic subcutaneous nodules of variable size, located over bony prominences and containing the adult worms (
Other classical clinical pictures include “lizard skin” with dry ichthyosis-like lesions with a mosaic pattern resembling the scales of a lizard (
“Hanging groins” consists of folds of atrophic inelastic skin in the inguinal region associated with lymphadenopathy. In an endemic population, the most common skin manifestation is CPOD, followed by DPM and ATR. Different clinical pictures are not mutually exclusive, because two or more patterns may be present simultaneously, and one pattern may evolve into another pattern.
Expected results of diagnostic studies
The diagnosis of onchocerciasis rests on the demonstration of living microfilaria in skin biopsies. Bloodless shave biopsies or “skin snips” are typically obtained by lifting the skin with the tip of a needle and excising a superficial disk of skin with a razor blade, or by scraping the skin tangentially with a corneoscleral punch. Snips are obtained bilaterally from the shins, the buttocks, and the iliac crests. In Central and South America, where the clinical manifestations typically are more severe on the upper trunk, skin snips are obtained from the scapular areas.
The snips are then placed in normal saline and inspected at intervals under the microscope for emerging spirochete-like microfilariae. Microscopic demonstration of microfilariae is 100% specific for onchocerciasis; however, the technique is rather insensitive in latent or early disease with a small microfilarial load.
Immunodiagnosis has recently been made available by the development of various recombinant antigens; however, this test cannot reliably distinguish between past and present infection. A polymerase chain reaction (PCR) assay was recently exploited to detect the repetitive DNA sequence known as O-150 (found only in Onchocerca volvulus) in skin snips.
In spite of great promise in terms of high sensitivity, these newer techniques are not yet routinely available under field conditions. The Masotti patch test is based on a contact hypersensitivity reaction induced by dead and dying microfilaria after topical application of diethylcabamazine. In spite of high sensitivity and specificity compared to skin snip technique, the patch test is hampered by varying degrees of sensitivity in different geographical areas and by its inability to identify individuals with light infestation.
Elevated levels of IgE, which are common in helmet infestations, are of low diagnostic significance in patients living in endemic areas due to high parasitic comorbidities, but can be of diagnostic importance in returning travelers with discrete skin manifestations.
Differential diagnoses include pruritic disorders, stasis dermatitis, and other eczemas, as well as vitiligo.
Who is at Risk for Developing this Disease?
Onchocerciasis occurs in more than 30 countries of tropical sub-Saharan Africa—the African onchocercal belt extending from Senegal in the West to Ethiopia in the East.
Onchocerciasis also occurs to a much lesser degree in Central and South America, Yemen, and Saudi Arabia. An estimated 18 million people are currently infested. Of these, 4 million patients have skin manifestations and 2 million are blind or severely visually impaired.
Symptoms vary with geographical location; epidemiological studies indicate that onchocerciasis manifests in two main forms usually termed “Savannah” and “Forest.” Patients living in the western savannah woodland have a high prevalence of blindness, whereas cutaneous symptoms are more prevalent in the rainforest and in the East African highlands, extending from Ethiopia to Malawi.
Onchocercal depigmentation is less commonly seen in patients from East Africa; lymphadenopathy is more common in the rainforest; and severe skin atrophy is commonly encountered in the savannah, where the microfilarial load tends to be greater. Travelers may acquire the disease during their stay in endemic areas.
What is the Cause of the Disease?
Onchocerciasis or “river blindness” results from infestation by the nematode, Onchocerca volvulus, which is spread by blackflies belonging to the genus Simulium that feed near fast-flowing rivers. When biting humans living near the rivers, the blackflies ingest skin-dwelling microfilaria, which then go through two additional larval stages in the fly over the next week. When the blackfly then bites another human being, the infective larvae escape through the wound and penetrate the tissues to develop into adult (macro)filariae that can be found in subcutaneous nodules scattered around the body.
The nodules, which range from the size of a pea to that of a golf ball, typically contain two to four adult worms that can reach a length of 80cm. The female filariae can live for as long as 15 years, during which time they produce millions of living embryos of microfilaria (each about 0.3mm long). Each day, one female worm releases 500-700 microfilariae. The incubation period is usually 1-2 years, but microfilariae can be detected as early as 3 months after exposure in an epidemic area. The microfilariae can survive 2-3 years.
Wolbachia endobacteriae are symbiants of most major human filariae, including O. volvulus, and are essential for growth, development, embryogenesis, and fertility of their nematode host. Since Wolvachia depletion has been shown to cause long-term sterilization of the adult female filaria, drugs targeting Wolbachia have emerged as a new promising filariacidal regimen in onchocerciasis.
Although not well characterized, the immunopathogenesis of onchocerciasis appears to correlate with the parasite load and with the clinical picture. The severe form of onchocercal dermatitis, known as “sowda” occurs during the parasite-destroying phase of the infestation. It is associated with a delayed hypersensitivity immune response, usually observed in patients with small loads of microfilariae.
In contrast, individuals with large microfilarial loads often lack an active immunological response. Th2 class cytokines including IL-4 and IL-5 have been shown to play a role in the mediation of the antifilarial response, and recently a subset of CD4+ T cells, T regulatory-1 (Tr1), with immunosuppressive capacity were suggested to play a role in counteracting Th2-driven inflammatory responses in patients with high microfilariae load but discrete signs of onchodermatitis.
Systemic Implications and Complications
Eye symptoms, rarely encountered in returning travelers, are common in patients living in endemic areas. Onchocercal ocular disease (OCD) covers a wide spectrum, ranging from mild symptoms such as itching, redness, pain, photophobia, diffuse keratitis, and blurring of vision, to more severe symptoms of corneal scarring, night blindness, intraocular inflammation, glaucoma, visual field loss, and eventually blindness.
In untreated populations, the progressive nature of OCD was responsible for the existence of entire villages in which the older inhabitants were blind and only the youngsters had functional vision This phenomenon was first observed in villages in proximity of rivers, the breeding site of the Simulium black fly, hence the name “river blindness”.
Ocular lesions are usually bilateral and can affect various structures of both the anterior and posterior segments of the eye. Anterior segment disease is related to the presence of intraocular living or dead microfilariae. In the anterior chamber, the microfilariae can be seen with a slit lamp. Dead microfilariae may cause severe anterior uveitis with formation of synaechiae, cataract, and glaucoma.
Confluent opacities may obscure major portions of the cornea, ultimately leading to a sclerosing keratitis with fibrocascular pannus and marked reduction of visual functions. Posterior segment disease manifests as atrophy of the retinal-pigment epithelium and is associated with choroido-retinal scarring and subretinal fibrosis. Optic neuritis followed by postneuritic atrophy, may occur.
Ophthalmologic workup includes: best-corrected visual acuity, slit-lamp examination of the anterior segment, intraocular pressure measurement, indirect ophthalmoscopy of the fundus, and refraction. Patients with abnormal posterior segment findings should undergo fluorescein angiography of the choroid and retinal vessels.
Two drugs are used in treatment of onchocerciasis:
Ivermectin, a synthetic derivative of a macrocyclic lactose produced by the actinomycete Streptomyces avermitis, acts as an agonist of the parasite neurotransmitter, gamma-aminobutyric acid (GABA), and induces an influx of Cl- through channels not regulated by GABA. Ivermectin is an efficient microfilaricidal, and although it impairs the release of microfilariea, it does not kill the adult worm.
Ivermectin is used in World Health Organization (WHO)-sponsored mass drug distribution programs, and is provided free of charge by the manufacturer to countries endemic for onchocerciasis. Ivermectin resistance has been reported in Ghana. Ivermectin is well tolerated, causing mild adverse effects in approximately 10% of patients. The adverse effects usually occur within the first 48 hours of treatment, and appear to attenuate with repeated administrations. Adverse effects recorded include: edema, fever, pruritus, arthralgias, lymphadenitis, and postural hypotension.
Doxycycline, like other tetracycline antibiotics, targets the Wolbachia endosymbionts leading to adult female worm sterility. Doxycycline has emerged as an effective macrofilaricidal drug. Though not practical in mass drug distribution programs, doxycycline is beneficial in the treatment of symptomatic patients in endemic and nonendemic areas. Side effects are sparse and most dermatologists are acquainted with the use of the drug.
Optimal Therapeutic Approach for this Disease
At least three different scenarios exist for treating patients with onchocerciasis:
Mass drug administration of populations living in endemic areas, with the purpose of controlling transmission
Individual drug administration to symptomatic patients living in endemic areas, with the purpose of reducing symptoms
Individual drug administration to symptomatic patients with low or no risk of re-infection, living in nonendemic areas (typically returning travellers from endemic to non-endemic areas). Only individual drug administration will not be considered here.
Patients living in endemic areas with ongoing transmission Ivermectin, 150ug/kg in a single dose, repeated every 3-6 months
(Rationale: Ivermectin primarily targets skin microfilariae. Although repeated doses of ivermectin have a moderate macrofilarcidal effect, surviving adult worms might resume release of microfilariae, whereas ivermectin treatment should be given for the whole life-span [12-15 years] of the adult worm)
Patients living/returning to nonendemic areas
Doxycycline 100mg/day for 5 weeks + ivermectin (single dose) at the end of the doxycycline treatment or after 4-6 months
(Rationale: Doxycycline causes adult female worm sterility, impeding the release of microfilariae to the skin. In order to diminish the skin load of already existing microfilariae, a single dose of ivermectin is added at the end of the doxycycline course. Doxycycline has no place in the treatment of patients living in endemic areas who run the risk of being re-infected and therefore would need constant or repeated doxycycline courses.)
Pruritus, dermatitis, and eye symptoms are directly correlated to the presence of microfilariea in the tissues and reduction in the microfilariae load is correlated with amelioration of symptoms; however, symptomatic relief is not immediate, and use of conventional antipyritics, antihistamines, and topical steroids to control pruritus and dermatitis is indicated at least until the effect of the antimicrofilarial treatment takes place.
Inform the patient that ivermectin, even given as a single dose, is effective in controlling skin and eye symptoms within 3-6 months. There are conflicting data regarding the effectiveness of the drug in reducing onchocercal pruritus.
Explain to the patient that onchocerciasis is not contagenous in nonendemic areas, since infective Simulus blackflies are required for transmission of the disease.
Unusual Clinical Scenarios to Consider in Patient Management
Ivermectin should not be used in pregnant women, during the first month of lactation, in children who weigh less than 15kg, or in patients in poor health.
Doxycycline should not be given to pregnant women or children below the age of 9.
In pregnant women, symptomatic antipruretic measures constitute the only treatment option.
What is the Evidence?
Murdoch, ME, Hay, RJ, Mackenzie, CD, Williams, JF, Ghalib, HW, Cousens, S. "A clinical classification and grading system of the cutaneous changes in onchocerciasis". Br J Dermatol . vol. 129. 1993. pp. 260-69.(Provides a detailed clinical description with superb illustrations of the different types of onchodermatitis)
Hagan, M. "Onchocercal dermatitis: Clinical impact". Ann Trop Med Parasitol. vol. 92. 1998. pp. S85-96.(Comprehensive review of natural history, clinical features and epidemiology)
Murdoch, ME. "Onchodermatitis". Curr Opin Infect Dis . vol. 23. 2010. pp. 124-31.(Up-to-date overview of clinical features, immunopathogenesis, and treatment options, with emphasis of Wolbachia-targeting strategies)
Taylor, MJ, Hoerauf, A, Bockarie, M. "Lymphatic filariasis and onchocerciasis". Lancet . vol. 376. 2010. pp. 1175-85.(Newest update on clinical, diagnostic, and therapeutic aspects)
McCarthy, JS, Ottesen, EA, Nutman, TB. "Onchocerciasis in endemic and non-endemic populations: Differences in clinical presentation and immunological findings". J Infect Dis . vol. 170. 1994. pp. 735-41.(Compares the clinical and laboratory findings in returning visitors and endemic subjects)
BenEzra, D, BenEzra, D, Ohno, S, Secchi, A, Alio, J. "Anterior segment intraocular inflamation guidelines". Martin Dunitz. 2000. pp. 75-83.(Comprehensive description of onchocercal ocular disease [OCD])
van Latem, Y, Lopes, C. "Treatment of onchocerciasis". Drugs . vol. 52. 1996. pp. 861-69.(Overview of treatment options, with detailed discussion of mechanism of action, dosage, and adverse effects of the individual drugs)
Hoerauf, A. "Filariasis: New drugs and new opportunities for lymphatic filariasis and onchocerciasis". Curr Opin Infect Dis . vol. 21. 2008. pp. 673-81.(Up-to-date review of newest treatment strategies both for mass drug distribution and individual drug distribution)
Copyright © 2017, 2012 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
- Optimal Treatment Regimens for Oldest Patients Is an Emerging Challenge for Radiation Oncology
- Emerging Combination Therapies for the Management of Multiple Myeloma: The Role of Elotuzumab
- Induction Regimens for Untreated Multiple Myeloma Compared for ORR, OS, PFS
- Value of Type and Crossmatch Prior to Daratumumab Administration
- Bullying Common to Nursing Students
- To Better Serve Patients With Cancer, Navigators Need Better Systems
- Physical Activity Improves Cognitive Function for Breast Cancer Survivors
- Risk of Lung Cancer Increases With Diets Higher in Saturated Fats
- Mechanisms Identified for Curcumin Resensitization of Cancer Cells
- Value of Type and Crossmatch Prior to Daratumumab Administration
- Colorectal Cancer Recurrence Lower in Survivors Who Exercise
- Cancer Patient Caregivers Have Increased Burden With Assessment Dissonance
- Sexual Dysfunction in Women With Cancer: A Review of Available Interventions
- Value of Type and Crossmatch Prior to Daratumumab Administration
- Colorectal Cancer Mortality Rates Down in African Americans
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|