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DEFLUX
Miscellaneous urogenital disorders
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Drug Name:

DEFLUX Rx

Generic Name and Formulations:
Dextranomer microspheres 50mg/mL viscous gel in stabilized hyaluronic acid 15mg/mL carrier gel; implant for submucosal inj.

Company:
Valeant Pharmaceuticals, Inc

Therapeutic Use:

Indications for DEFLUX:

Vesicoureteral reflux (VUR) grades II–IV in children.

Adult:

Not applicable.

Children:

<1yr: not recommended. ≥1yr: see literature. Must use Deflux metal needle for administration. Inject submucosally in urinary bladder near the ureteral orifice.

Contraindications:

Non-functional kidney. Hutch diverticulum. Ureterocele. Active voiding dysfunction. Ongoing UTI.

Warnings/Precautions:

Do not inject intravascularly. Must be administered by qualified surgeon experienced in the use of cystoscope and trained in subureteric injection procedures. Use of >6mL (3mL at each ureteral orifice) at same treatment session: not recommended. Treatment of duplex systems has not been studied. Ureters with grossly dilated orifices. Infection and bleeding risks associated with cystoscopic procedure.

Adverse Reactions:

UTI, ureteral dilatation, nausea, vomiting, abdominal pain.

How Supplied:

Single-use syringe (1mL)—1

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