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DDAVP
Overactive bladder/enuresis
Pituitary disorders
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Drug Name:

DDAVP Rx

Generic Name and Formulations:
Desmopressin acetate 0.1mg, 0.2mg; scored tabs.

Company:
Ferring Pharmaceuticals, Inc.

Therapeutic Use:

Indications for DDAVP:

Primary nocturnal enuresis.

Adults and Children:

<6yrs: not recommended. ≥6yrs: initially 0.2mg once daily at bedtime; individualize; max 0.6mg.

Contraindications:

Moderate to severe renal impairment (CrCl <50mL/min). Hyponatremia, or history of.

Warnings/Precautions:

Monitor fluid intake, urine volume and osmolality. Fluid/electrolyte imbalance (eg, cystic fibrosis). Habitual or psychogenic polydipsia. Coronary artery insufficiency. Hypertension. Supervise admin in children. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Caution with other pressor agents, drugs that may increase the risk of water intoxication with hyponatremia (eg, tricyclic antidepressants, SSRIs, chlorpromazine, opiates, NSAIDs, lamotrigine, carbamazepine). Possible convulsions with oxybutynin, imipramine.

Pharmacological Class:

Vasopressin (synthetic).

Adverse Reactions:

Headache, water intoxication, hyponatremia; seizures in children from plasma hypoosmolality (rare).

How Supplied:

Tabs—100

Indications for DDAVP:

Central (cranial) diabetes insipidus. Temporary polyuria and polydipsia following head trauma or surgery in the pituitary region.

Adult:

When switching to tabs give 1st oral dose 12hrs after last intranasal dose. Initially 0.05mg twice daily; individualize, usual range: 0.1–1.2mg/day in 2–3 divided doses.

Children:

<4yrs: not recommended. ≥4yrs: initially 0.05mg once daily; individualize.

Contraindications:

Moderate to severe renal impairment (CrCl <50mL/min). Hyponatremia, or history of.

Warnings/Precautions:

Monitor fluid intake, urine volume and osmolality. Fluid/electrolyte imbalance (eg, cystic fibrosis). Habitual or psychogenic polydipsia. Coronary artery insufficiency. Hypertension. Inj: Predisposition to thrombosis. Nasal mucosal changes (nasal forms). Young children. Elderly. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Caution with other pressor agents, drugs that may increase the risk of water intoxication with hyponatremia (eg, tricyclic antidepressants, SSRIs, chlorpromazine, opiates, NSAIDs, lamotrigine, carbamazepine). Possible convulsions with oxybutynin, imipramine.

See Also:

DDAVP NASAL SPRAY

DDAVP RHINAL TUBE

DDAVP INJECTION

Pharmacological Class:

Vasopressin (synthetic).

Adverse Reactions:

Headache, nausea, flushing, abdominal cramps, vulval pain, water intoxication, hyponatremia, nasal congestion or rhinitis (nasal forms), inj site reaction; rare: changes in BP, severe allergic reactions, seizures in children from plasma hypoosmolality, thrombotic events (inj).

How Supplied:

Tabs—100; Nasal spray—5mL (50 sprays); Rhinal tube—2.5mL (w. 2 rhinal tubes); Amp (1mL)—10; Multi-dose vial (10mL)—1

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