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DAYSEE
Contraception
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Drug Name:

DAYSEE Rx

Generic Name and Formulations:
Levonorgestrel 0.15mg, ethinyl estradiol 30mcg (84 tabs); ethinyl estradiol 10mcg (7 tabs).

Company:
Lupin Pharmaceuticals, Inc.

Therapeutic Use:

Indications for DAYSEE:

Oral contraception.

Adult:

1 tab daily for 91 days; repeat. Use Sunday-start regimen. Take pills in order (84 levonorgestrel + ethinyl estradiol tabs, then 7 ethinyl estradiol tabs).

Children:

Premenarchal: not recommended.

Contraindications:

High risk of arterial or venous thrombotic disease (eg, smokers or migraineurs over age 35, history of DVT or PE, cerebrovascular or coronary artery disease, thrombogenic valvular disease, atrial fibrillation, subacute bacterial endocarditis, hypercoagulopathies, uncontrolled hypertension, diabetes with vascular disease, headaches with focal neurologic symptoms). Undiagnosed abnormal genital bleeding. Breast or other estrogen- or progestin-sensitive neoplasms. Hepatic disease or tumors. Pregnancy.

Warnings/Precautions:

Increased risk of cardiovascular events (eg, MI, stroke, VTE) esp. smokers >35yrs of age. Discontinue if thrombotic event, unexplained visual changes, or jaundice occurs, and at least 4 weeks before through 2 weeks after surgery associated with increased risk of thromboembolism. Gallbladder disease. Diabetes. Prediabetes. Uncontrolled dislipidemias. Hypertriglyceridemia. Pregnancy-related cholestasis. Depression. Hereditary angioedema. Evaluate significant changes in headaches, irregular uterine bleeding, amenorrhea. Monitor blood pressure. Do regular complete physical exams. Nursing mothers: not recommended.

Interactions:

May be antagonized by CYP3A4 or other enzyme inducers (eg, barbiturates, bosentan, carbamazepine, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, St. John’s wort, topiramate); use backup contraception. May be affected by protease inhibitors, NNRTIs, atorvastatin, acetaminophen, ascorbic acid, itraconazole, ketoconazole. May antagonize lamotrigine. May affect laboratory tests (eg, coagulation factors, lipids, glucose tolerance, binding proteins). May need dose adjustment of thyroid hormones.

Pharmacological Class:

Progestin + estrogen.

Adverse Reactions:

Irregular and/or heavy uterine bleeding, weight gain, acne, nausea, breast tenderness, headache, cholelithiasis, pancreatitis, abdominal pain, depression; angioedema, others (see full labeling).

How Supplied:

Extended-cycle wallets (13-week supply)—1, 2

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