Use of statins may reduce esophageal cancer risk

This article originally appeared here.
Statins May Lower Esophageal Cancer Risk
Statins May Lower Esophageal Cancer Risk

(HealthDay News) -- Statins may lower the risk of esophageal cancer, particularly in patients with Barrett's esophagus, according to a review published in the June issue of Clinical Gastroenterology and Hepatology.

Siddharth Singh, M.D., from the Mayo Clinic in Rochester, Minn., and colleagues conducted a literature review through August 2012 to identify 13 studies that evaluated exposure to statins, reported the development of esophageal cancer, and reported relative risks or odds ratios (OR) or provided data for their estimation.

The researchers found that the included studies reported 9,285 cases of esophageal cancer among 1,132,969 patients. A significant (28 percent) reduction in the risk of esophageal cancer was seen among patients who took statins (adjusted OR, 0.72), in a meta-analysis, although there was considerable heterogeneity among studies. Among a subset of patients known to have Barrett's esophagus (five studies; 312 esophageal adenocarcinomas [EACs] in 2,125 patients), after adjusting for potential confounders, statins were associated with a significant (41 percent) decrease in the risk of EAC, (adjusted OR, 0.59). To prevent one case of EAC in patients with Barrett's esophagus, the number needed to treat with statins was 389.

"Based on meta-analysis of observational studies, statin use may be associated with lower risk of esophageal cancer, particularly risk of EAC in patients with Barrett's esophagus," the authors write.

Abstract
Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs