Surgery for advanced laryngeal cancer provides survival benefit

This article originally appeared here.
Survival Advantage With Surgery in Advanced Laryngeal Cancer
Survival Advantage With Surgery in Advanced Laryngeal Cancer

(HealthDay News) -- For patients with advanced laryngeal cancer, there is a small but significant survival advantage with surgical treatment versus laryngeal conservation, according to a study published online Aug. 21 in JAMA Otolaryngology-Head & Neck Surgery.

Uchechukwu C. Megwalu, M.D., M.P.H., and Andrew G. Sikora, M.D., Ph.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues conducted a population-based study involving 5,394 patients who received a diagnosis of stage III or IV laryngeal squamous cell carcinoma from 1992 to 2009. Survival outcomes were assessed for laryngeal conservation versus surgical therapy.

The researchers found that two-year and five-year disease-specific (DSS) and overall survival (OS) were better for patients undergoing surgical therapy versus nonsurgical therapy (DSS: 70 versus 64 percent and 55 versus 51 percent, respectively; P < 0.001; OS: 64 versus 57 percent and 44 versus 39 percent, respectively; P < 0.001). After stratification by year-of-diagnosis cohorts, the between-group difference in DSS and OS remained significant (P < 0.001). With subsequent year-of-diagnosis cohorts, the survival gap narrowed consistently. After adjustment for multiple confounding variables, nonsurgical patients had worse DSS and OS (hazard ratios, 1.33 and 1.32, respectively).

"Patients need to be made aware of the modest but significant survival disadvantage associated with nonsurgical therapy as part of the shared decision-making process during treatment selection," the authors write.

Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs