Potential biomarker, drug target ID'd for adult leukemia

This article originally appeared here.
Potential Biomarker, Drug Target ID'd for Adult Leukemia
Potential Biomarker, Drug Target ID'd for Adult Leukemia

(HealthDay News) -- Tumors from adults with B-cell precursor acute lymphoblastic leukemia (B-ALL) have epigenetic changes, leading to the identification of a potential biomarker and a possible drug target, according to research published online Oct. 29 in Cancer Discovery.

Huimin Geng, Ph.D., from the Weill Medical College of Cornell University in New York City, and colleagues conducted DNA methylation and gene expression profiling on tumor samples from 215 adults with B-ALL who were participating in a phase III clinical trial, as well as normal control B cells.

The researchers found that, in B-ALL positive for the BCR-ABL1 fusion, aberrant cytosine methylation patterning was associated with overexpression of IL2RA (CD25). The clinical trial showed that CD25 expression was associated with a poor outcome, regardless of BCR-ABL1 status. In B-ALL positive for the E2A-PBX1 fusion, aberrant DNA methylation patterning was associated with direct fusion protein binding. MLL rearrangements were associated with several epigenetic changes, most notably targeting oncogenic BCL6, and blockade or loss of function of BCL6 suppressed proliferation and survival of cells with MLL rearrangements.

"We observed that aberrant epigenetic regulation occurs universally and is distributed to specific gene sets in genetically defined B-ALL subtypes associated with poor outcomes," Geng and colleagues conclude. "We expect these studies to trigger therapeutic trials of BCL6 inhibitors in MLL leukemia and the application of CD25 as a putative biomarker for risk stratification in B-ALLs."

Abstract
Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs