MicroRNAs can accurately identify pancreatic cancer

This article originally appeared here.
MicroRNAs Accurately ID Pancreatic Cancer
MicroRNAs Accurately ID Pancreatic Cancer

(HealthDay News) -- Increased expression of a microRNA (miRNA) panel seems highly accurate for diagnosing pancreatic ductal adenocarcinoma (PDAC), according to a study published online Oct. 28 in the American Journal of Gastroenterology.

Gregory A. Cote, M.D., from Indiana University School of Medicine in Indianapolis, and colleagues examined the differential expression of select miRNAs in plasma and bile among 77 patients with treatment-naive PDAC, 67 patients with chronic pancreatitis with bile/pancreatic duct pathology, and 71 controls with choledocholithiasis but normal pancreata. A training cohort (95 patients) and validation cohort (120 patients) were used to establish and test the PDAC Signature Panel.

The researchers confirmed differential expression of nine out of 10 miRNAs in plasma and seven out of 10 in bile using the training cohort. For distinguishing PDAC, excellent accuracy was seen for five of these miRNAs (miR-10b, -155, -106b, -30c, and -212). The sensitivity and specificity were 95 and 100 percent, respectively, for a PDAC Panel derived from plasma and 96 and 100 percent, respectively, for a PDAC Panel derived from bile in the training and validation cohorts.

"Increased expression of miRNA-10b, -155, and -106b in plasma appears highly accurate in diagnosing PDAC," the authors write. "Additional studies are needed to confirm this Panel and explore its value as a prognostic test."

Full Text

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs