Little association between metformin use and breast cancer mortality

This article originally appeared here.
Post-Breast Cancer, Metformin Has No Effect on Mortality
Post-Breast Cancer, Metformin Has No Effect on Mortality

(HealthDay News) -- For older women with diabetes and breast cancer, there is no association between metformin use and all-cause or breast cancer-specific mortality, according to a study published online April 30 in Diabetes Care.

Iliana C. Lega, M.D., from the Women's College Hospital in Toronto, and colleagues conducted a population-based study involving 2,361 women aged 66 years or older diagnosed with diabetes and breast cancer. The correlation between cumulative duration of past metformin use and all-cause and breast cancer-specific mortality was assessed.

During a mean follow-up of 4.5 years, the researchers identified 1,101 deaths (46.6 percent), of which 16.3 percent were breast cancer-specific. There was no significant association observed between cumulative duration of past metformin use and all-cause or breast cancer-specific mortality.

"In summary, we conducted a large population-based study to investigate the effects of metformin therapy on mortality after breast cancer in a diabetic population," the authors write. "Cumulative exposure of metformin was not significantly associated with all-cause or breast cancer-specific mortality in our incident diabetic cohort when modeled as a time-varying covariate."

Abstract
Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs