Injectable radioactive polymer slows tumor growth

This article originally appeared here.
Injectable Radioactive Polymer Slows Tumor Growth
Injectable Radioactive Polymer Slows Tumor Growth

(HealthDay News) -- An injectable radioactive polymer substantially slows tumor growth and avoids the need for surgical implantation in mice, according to a study published in the Nov. 15 issue of Cancer Research.

To determine whether brachytherapy could be performed without the need for surgical implantation of sealed radioactive "seeds" within a tumor and subsequent device removal, Wenge Liu, M.D., Ph.D., from Duke University in Durham, N.C., and colleagues tested a thermally responsive radioactive peptide polymer solution, composed of radiolabeled elastin-like polypeptide, that self-assembles into radionuclide seeds after intratumoral injection.

The researchers found that the formation of the nontoxic and biodegradable polymer seeds showed prolonged retention in the tumor, with about 85 percent retention of the radionuclide a week after injection. In mice bearing either human head and neck cancers or human prostate cancers, the radioactive polymers elicited a tumor growth delay in 100 percent of tumors, and cured 67 percent of animals after a single injection.

"These results suggest that in situ self-assembly of biodegradable and injectable radionuclide-containing polypeptide seeds could be a promising therapeutic alternative to conventional brachytherapy," Liu and colleagues conclude.

One author has a financial interest in PhaseBio Pharmaceuticals, which has licensed the technology described in the study.

Abstract
Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs