Higher carotenoid levels tied to lower breast cancer risk

This article originally appeared here.
Higher Carotenoid Levels Tied to Lower Breast Cancer Risk
Higher Carotenoid Levels Tied to Lower Breast Cancer Risk

(HealthDay News) -- Higher circulating levels of carotenoids correlate with a reduced risk of breast cancer, according to research published online Dec. 6 in the Journal of the National Cancer Institute.

A. Heather Eliassen, Sc.D., from Brigham & Women's Hospital in Boston, and colleagues analyzed pooled data from eight cohort studies, comprising more than 80 percent of the world's published prospective data on plasma or serum carotenoids and breast cancer. The analysis included 3,055 case subjects and 3,956 matched controls. Participant carotenoid levels were recalibrated to a common standard by reassaying 20 plasma or serum samples from each cohort together at the same laboratory.

The researchers found significant inverse associations between breast cancer and α-carotene (top versus bottom quintile relative risk [RR], 0.87; Ptrend = 0.04), β-carotene (RR, 0.83; Ptrend = 0.02), lutein+zeaxanthin (RR, 0.84; Ptrend = 0.05), lycopene (RR, 0.78; Ptrend = 0.02), and total carotenoids (RR, 0.81; Ptrend = 0.01). There was no significant association between β-cryptoxanthin and breast cancer risk. Stronger associations were found for several carotenoids and estrogen receptor negative (ER−) tumors than for ER+ tumors; for example, for the top versus the bottom quintile of β-carotene, the RR was 0.52 for ER− and 0.83 for ER+ tumors.

"This comprehensive prospective analysis suggests women with higher circulating levels of α-carotene, β-carotene, lutein+zeaxanthin, lycopene, and total carotenoids may be at reduced risk of breast cancer," the authors write.

The study was partially funded by DSM Nutritional Products (formerly Roche Vitamins).

Abstract
Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs