Herpes zoster vaccine effective with chemotherapy

This article originally appeared here.
Herpes zoster vaccine effective with chemotherapy
Herpes zoster vaccine effective with chemotherapy

(HealthDay News) -- Zoster vaccine is effective even for individuals who subsequently undergo chemotherapy, according to a study published online Aug. 4 in Clinical Infectious Diseases.

Hung Fu Tseng, Ph.D., M.P.H., from Kaiser Permanente Southern California in Pasadena, and colleagues examined the effectiveness of zoster vaccine in patients who subsequently underwent chemotherapy. Data were included for a cohort of Kaiser Permanente Southern California members, aged 60 years or older, treated with chemotherapy.

The researchers identified 91 and 583 cases of herpes zoster in the vaccinated and unvaccinated cohorts, respectively, for an incidence rate ratio of 12.87 versus 22.05 per 1,000 person-years. The 30-month cumulative incidence was 3.28 and 5.34 percent, respectively, in the vaccinated and unvaccinated groups (P < 0.05). The adjusted hazard ratio was 0.58 for herpes zoster, with no significant variation by age, sex, or race. In a small subgroup of patients receiving zoster vaccine within 60 days before chemotherapy, herpes zoster incidence rates remained increased. No vaccinated patients and six unvaccinated patients underwent hospitalization for herpes zoster.

"Zoster vaccine continues to protect against herpes zoster if recipients later undergo chemotherapy," the authors write. "Our findings provide an additional rationale for offering zoster vaccine to indicated adults while they are immunocompetent."

Several authors disclosed financial ties to Novartis Vaccines and Merck.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs