Expression, genomic patterns predict sarcoma progression

This article originally appeared here.
Expression, Genomic Patterns Predict Sarcoma Progression
Expression, Genomic Patterns Predict Sarcoma Progression

(HealthDay News) -- The Complexity Index in Sarcoma (CINSARC) and Genomic Index prognostic signatures are valid independent methods of assessing synovial sarcoma (SS) prognosis, according to a study published online Jan. 14 in the Journal of Clinical Oncology.

Pauline Lagarde, of the Institut Bergonié in Bordeaux, France, and colleagues examined whether expression and genomic prognostic signatures related to chromosome integrity in sarcomas and gastrointestinal stromal tumors (CINSARC and Genomic Index) could predict outcomes in SS. In a training/validation approach, 100 patients with primary untreated SS tumors underwent expression and genomic profiling.

The researchers found that CINSARC and Genomic Index exhibited significant independent and validated prognostic values. Fourteen genes in the CINSARC signature were identified through comparing expression profiles of tumors with or without metastasis; and in an independent cohort, KIF14 and CDCA2, were validated as prognostic markers. Metastasis was associated with genome complexity in both adult and pediatric SS; the adult genome was more frequently rearranged, and, accordingly, metastasis did not develop in pediatric patients who had an even genomic profile.

"To conclude, this study offers results that are meaningful for understanding the metastatic potential of sarcomas in general, and particularly in SS for which this study provides a biologic explanation for the distinct aggressiveness of pediatric and adult SS," the authors write.

Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs