Everolimus does not affect survival rate for advanced liver cancer

This article originally appeared here.
Everolimus Does Not Improve Survival in Advanced Liver CA
Everolimus Does Not Improve Survival in Advanced Liver CA

(HealthDay News) -- Everolimus does not improve overall survival in patients with advanced liver cancer, according to a study published in the July 2 issue of the Journal of the American Medical Association.

Andrew X. Zhu, M.D., Ph.D., from Massachusetts General Hospital in Boston, and colleagues conducted a multi-national, phase 3 trial that included 546 adults with Barcelona Clinic Liver Cancer stage B or C hepatocellular carcinoma and Child-Pugh A liver function. Either the patients' disease had progressed during or after sorafenib or they were intolerant of sorafenib. Participants were randomized (2:1) to receive everolimus (7.5 mg/day; 362 patients) or matching placebo (184 patients), both continued until disease progression or intolerable toxicity.

The researchers observed no significant difference in overall survival between treatment groups (hazard ratio [HR], 1.05; 95 percent confidence interval [CI], 0.86 to 1.27; P = 0.68; median overall survival, 7.6 months with everolimus and 7.3 months with placebo). With everolimus, the median time to progression was 3.0 months, and the median time to progression was 2.6 months with placebo (HR, 0.93; 95 percent CI, 0.75 to 1.15). The most common adverse events (grade 3/4) with everolimus were anemia, asthenia, and decreased appetite. There were no hepatitis C viral flares; however, hepatitis B viral reactivation was seen in 39 patients (29 everolimus and 10 placebo).

"Everolimus did not improve overall survival in patients with advanced hepatocellular carcinoma whose disease progressed during or after receiving sorafenib or who were intolerant of sorafenib," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Novartis, which funded the study and manufactures everolimus.

Full Text (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs