ESMO: Dabrafenib + trametinib active in metastatic melanoma

This article originally appeared here.
ESMO: Dabrafenib + Trametinib Active in Metastatic Melanoma
ESMO: Dabrafenib + Trametinib Active in Metastatic Melanoma

(HealthDay News) -- For patients with metastatic melanoma with BRAF V600 mutations, combination therapy with a selective BRAF inhibitor (dabrafenib) and a mitogen-activated protein kinase inhibitor (trametinib) is tolerable and active, according to a study published online Sept. 29 in the New England Journal of Medicine to coincide with presentation at the annual meeting of the European Society for Medical Oncology, held from Sept. 28 to Oct. 2 in Vienna.

Keith T. Flaherty, M.D., from the Massachusetts General Hospital Cancer Center in Boston, and colleagues conducted an open-label phase 1 and 2 study involving 247 patients with metastatic melanoma and BRAF V600 mutations. The pharmacokinetic activity and safety of oral dabrafenib and trametinib was assessed in 85 patients, and 162 patients were randomly allocated to either dabrafenib plus trametinib or dabrafenib monotherapy.

The researchers identified dose-limiting toxic effects infrequently in patients receiving combination therapy (150 mg dabrafenib and 2 mg trametinib [150/2]). Cutaneous squamous cell carcinoma occurred in significantly more patients receiving monotherapy (19 percent) than in those receiving the combination 150/2 (7 percent). Pyrexia was more common in the combination group (71 percent) versus the monotherapy group (26 percent). The median progression-free survival was 9.4 months in the combination group versus 5.8 months in the monotherapy group (hazard ratio for progression or death, 0.39). The rate of complete or partial response was significantly higher in the combination versus the monotherapy group (76 versus 54 percent; P = 0.03).

"Dabrafenib and trametinib were safely combined at full monotherapy doses," the authors write. "We believe that the combination of dabrafenib and trametinib warrants further evaluation as a potential treatment for metastatic melanoma with BRAF V600 mutations and other cancers with these mutations."

Several authors are employees of GlaxoSmithKline, which funded the study and manufactures dabrafenib and trametinib.

Abstract
Full Text
More Information

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs