Cumulative metformin connected to post-prostate cancer mortality

This article originally appeared here.
Cumulative Metformin Linked to Mortality Post-Prostate Cancer
Cumulative Metformin Linked to Mortality Post-Prostate Cancer

(HealthDay News) -- Among elderly men with diabetes, increased cumulative duration of metformin following a prostate cancer (PC) diagnosis correlates with decreased all-cause and PC-specific mortality, according to a study published online Aug. 5 in the Journal of Clinical Oncology.

David Margel, M.D., Ph.D., from the University of Toronto, and colleagues analyzed data from several Ontario health care administrative databases to identify men (>66 years) with incident diabetes who subsequently developed PC. Within the cohort of 3,837 patients, they examined the impact of duration of antidiabetic medication exposure following diagnosis with PC on all-cause and PC-specific mortality.

The researchers found that the median age at PC diagnosis was 75 years. Over a median of 4.64 years of follow-up, 35 percent of patients died, with 7.6 percent dying from PC. The risk of PC-specific and all-cause mortality was significant decreased, in a dose-dependent manner, for cumulative duration of metformin treatment after PC diagnosis. For PC-specific mortality, the adjusted hazard ratio was 0.76 for each additional six months of metformin use. There was also a significant association with all-cause mortality but it declined over time, from a hazard ratio of 0.76 in the first six months to 0.93 between 24 and 30 months. For other antidiabetic drugs there was no relationship with cumulative use and either outcome.

"Increased cumulative duration of metformin exposure after PC diagnosis was associated with decreases in both all-cause and PC-specific mortality among diabetic men," the authors write.

Abstract
Full Text (subscription or payment may be required)
Editorial

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs