Cardiac risk from breast radiation decreased

Cardiac Risk From Breast Radiation Lower Than in Past
Cardiac Risk From Breast Radiation Lower Than in Past

(HealthDay News) -- Risk of cardiac events is increased by exposure from breast radiotherapy, though contemporary techniques, including lower radiation doses and prone positioning, have helped lower these risks, according to research published online Oct. 28 in JAMA Internal Medicine.

David J. Brenner, Ph.D., D.Sc., of Columbia University in New York City, and colleagues used historical data to estimate contemporary risks of major coronary events caused by radiotherapy for breast cancer.

The researchers found that the current patient-averaged mean cardiac dose was 1.37 Gy for standard supine-positioned radiotherapy, which was less than one-third of the dose reported for treatment during 1958 to 2001. The highest estimated radiotherapy-induced excess risk of major coronary events was seen in women with high baseline cardiac risk receiving left-sided radiotherapy in the supine position (3.52 percent), and the lowest excess risks were seen in women with low baseline risk receiving right-sided radiotherapy (<0.1 percent).

"Estimated lifetime risks of major coronary events for patients who receive radiotherapy for breast cancer are now in the range from 0.05 to 3.5 percent, with a typical value of 0.3 percent for a typical scenario," the authors write.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs