AACR: Hormone levels linked to breast cancer risk prediction

AACR: Multiple Hormone Levels Up Breast Cancer Risk Prediction
AACR: Multiple Hormone Levels Up Breast Cancer Risk Prediction

(HealthDay News) -- The addition of circulating hormone levels correlates with improved breast cancer risk prediction, according to a study presented at the American Association for Cancer Research's International Conference on Frontiers in Cancer Prevention Research, held from Oct. 27 to 30 in National Harbor, Md.

Shelley S. Tworoger, Ph.D., from Brigham and Women's Hospital in Boston, and colleagues used data from 473 cases of postmenopausal invasive breast cancer and 770 controls. The subset of hormones most associated with risk was identified and improvement in the area under the receiver operating characteristic curve (AUC) was assessed, using the Gail and Rosner risk prediction models.

The researchers found that estrone sulfate, testosterone, and prolactin correlated with a 8.6-point increase on the AUC in the Gail model and a 3.8-unit increase for the Rosner score in the training dataset (70 percent of data), and with changes of 5.0 and 5.1 units, respectively, in the independent dataset (30 percent of data). Using a subset including estrone sulfate, testosterone, prolactin, and sex-hormone binding globulin, the changes in AUC were 7.3 and 5.5 for the Gail and Rosner scores, respectively, in the training dataset and 12.5 and 8.3, respectively, in the independent dataset.

"The improvement in prediction when adding circulating hormone levels was better than the improvement observed by other studies that included mammographic density and genetic factors," Tworoger said in a statement.

Press Release
More Information

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs