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Survival Outcomes in Relapsed Hepatocellular Carcinoma Improved With Cabozantinib

Survival Outcomes in Relapsed Hepatocellular Carcinoma Improved With Cabozantinib

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Results of the double-blind phase 3 CELESTIAL study, presented at the 2018 Gastrointestinal Cancers Symposium, demonstrated efficacy of cabozantinib in patients with HCC who were previously treated with sorafenib.

OS Similar With Gemcitabine Plus S-1 vs Standard Therapy for Biliary Tract Cancer

OS Similar With Gemcitabine Plus S-1 vs Standard Therapy for Biliary Tract Cancer

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In a phase 3 study presented at the 2018 Gastrointestinal Cancers Symposium, researchers reported on OS outcomes with gemcitabine plus S-1 vs gemcitabine plus cisplatin in patients with advanced biliary tract cancer.

Urine Drug Testing Policy Can Assist Opioid Treatment Decisions

Urine Drug Testing Policy Can Assist Opioid Treatment Decisions

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Clinicians should use immunoassay screens and urine drug tests to determine compliance with chronic opioid therapy.

Resolving Vaginal Dryness in Women With a History of Breast Cancer

Resolving Vaginal Dryness in Women With a History of Breast Cancer

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What are some nonhormonal treatments that can improve vaginal dryness in women with a history of breast cancer?

Overall Survival Prolonged With HIPEC + Cytoreductive Surgery for Gastric Cancer

Overall Survival Prolonged With HIPEC + Cytoreductive Surgery for Gastric Cancer

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Data presented at the 2018 Gastrointestinal Cancers Symposium compared overall survival with cytoreductive surgery (CRS) alone for patients with gastric cancer and peritoneal carcinomatosis vs treatment with HIPEC plus CRS.

Better Postoperative Outcomes With RAMIE for Esophageal Cancer

Better Postoperative Outcomes With RAMIE for Esophageal Cancer

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Research presented at the 2018 Gastrointestinal Cancers Symposium described benefits seen with RAMIE vs chemotherapy or chemoradiotherapy plus OTE for esophageal cancer.

Distinct Patterns of Shiny White Streaks Strong Indicator of Melanoma

Distinct Patterns of Shiny White Streaks Strong Indicator of Melanoma

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Patients presenting with lesions with shiny white streaks on dermoscopy should undergo biopsy for possible melanoma.

Risk Factors for Arterial, Venous Thrombosis Differ in Polycythemia Vera

Risk Factors for Arterial, Venous Thrombosis Differ in Polycythemia Vera

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Researchers assessed outcomes for 587 patients with PV to determine the risk factors most likely to predict arterial or venous thrombosis in this patient population.

FDA Issues Warning for Rolapitant Injectable Emulsion in the Treatment of CINV

FDA Issues Warning for Rolapitant Injectable Emulsion in the Treatment of CINV

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FDA issues black box warning for rolapitant regarding the potential for anaphylaxis, anaphylactic shock, and other hypersensitivity reactions in patients receiving the injectable emulsion for CINV prophylaxis.

Breast Cancer Deaths Decrease Sharply Since 2000

Breast Cancer Deaths Decrease Sharply Since 2000

Improved therapies and better screening has led to a plunge in breast cancer deaths over the last two decades.

BRCA Mutation Improves Prognosis for 2-year Survival in Younger-onset TNBC

BRCA Mutation Improves Prognosis for 2-year Survival in Younger-onset TNBC

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Results from the POSH breast cancer study may influence decisions regarding treatments intended to reduce the incidence of second primary cancers in patients with BRCA-positive triple-negative breast cancer.

Patient Satisfaction Ratings Can Be Negatively Impacted by Nurse Staffing Ratio

Patient Satisfaction Ratings Can Be Negatively Impacted by Nurse Staffing Ratio

Perceptions of missed care are tied to higher patient-to-nurse ratios in England's hospitals, research indicates.

Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy

Dietary Estrogens Reduced Efficacy of Novel Breast Cancer Therapy

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A metabolomics study of the effect of palbociclib/letrozole combination on cancer cells discovered that consumption of foods with certain xenoestrogens has a negative effect on the treatment.

Fosfomycin Effective Alternate for Febrile Neutropenia Prophylaxis

Fosfomycin Effective Alternate for Febrile Neutropenia Prophylaxis

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A retrospective chart study demonstrated the effectiveness of fosfomycin as an antibacterial prophylaxis for febrile neutropenia in patients with hematologic cancer.

Adherence to Skin Cancer Screening Guidelines Beneficial in Management SCC in SOTRs

Adherence to Skin Cancer Screening Guidelines Beneficial in Management SCC in SOTRs

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Transplant recipients developed squamous cell carcinomas that did not appear to behave more aggressively than those that developed in the immunocompetent group.

Distress, Neuroticism Predict Long-term Emotional Distress After Cancer Diagnosis

Distress, Neuroticism Predict Long-term Emotional Distress After Cancer Diagnosis

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A literature sought to identify which signs and symptoms in patients with new cancer diagnoses indicate a greater likelihood for long-term emotional distress.

Monetary Incentives Improve Quit Attempts in Mentally Ill Smokers

Monetary Incentives Improve Quit Attempts in Mentally Ill Smokers

Abstinence-contingent incentives improved smoking cessation outcomes among economically disadvantaged smokers with mental illness.

Melatonin Derivatives Exhibit Cytotoxic Activity in Melanoma and Breast Cancer

Melatonin Derivatives Exhibit Cytotoxic Activity in Melanoma and Breast Cancer

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Melatonin and its analogues, in addition to their ability to regulate circadian rhythms, may exhibit cytotoxic activity via various cellular mechanisms.

Long-Term Night Shift Work Associated With Cancer Risk in Women

Long-Term Night Shift Work Associated With Cancer Risk in Women

The researchers observed a positive correlation between long-term night shift work and the risks of several different types of cancer.

Indications for Cabozantinib in Advanced RCC Expanded to First-line Therapy

Indications for Cabozantinib in Advanced RCC Expanded to First-line Therapy

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The FDA based its approval on data collected from the open-label, phase 2 CABOSUN study, for which researchers randomly assigned 157 patients with RCC to receive oral cabozantinib or sunitinib.

Pain Tolerance Lower in Abstinent Smokers Before, Following Surgery

Pain Tolerance Lower in Abstinent Smokers Before, Following Surgery

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Abstinent smokers may have reduced preoperative pain tolerance and increased postoperative opioid use compared with nonsmokers.

FDA Grants Breakthrough Therapy Designation to Lenvatinib Plus Pembrolizumab for RCC

FDA Grants Breakthrough Therapy Designation to Lenvatinib Plus Pembrolizumab for RCC

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Combination therapy with lenvatinib and pembrolizumab is granted Breakthrough Therapy Designation for the treatment of advanced or metastatic renal cell carcinoma (RCC).

Anxiety, Depression Higher, QOL Lower Between Chemotherapy Cycles for Breast Cancer

Anxiety, Depression Higher, QOL Lower Between Chemotherapy Cycles for Breast Cancer

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A longitudinal study assessed psychological status of postoperative patients with breast cancer between adjuvant chemotherapy for anxiety and depression.

Fluorouracil Associated With Reduced Surgery for Squamous Cell Carcinoma

Fluorouracil Associated With Reduced Surgery for Squamous Cell Carcinoma

A reduced risk of squamous cell carcinoma, but not basal cell carcinoma, was observed for one year in at-risk individuals treated with fluorouracil.

Smoking Quit Rates Not Improved With Use of Pharmaceutical Cessation Aids

Smoking Quit Rates Not Improved With Use of Pharmaceutical Cessation Aids

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Using data from the TUS-CPS, researchers sought to determine the effect of pharmaceutical smoking cessation aids on long-term quit rates among patients who smoke tobacco.

Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma

Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma

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The safety of breast implants has not been confirmed despite widespread use.

Handgrip Strength Test is Feasible to Predict Outcomes Among Patients with Cancer

Handgrip Strength Test is Feasible to Predict Outcomes Among Patients with Cancer

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Although dynapenia and weak HGS is associated with poor outcomes in patients with cancer, it is not routinely assessed in this population.

Surgery May Be Superior to Stereotactic Body RT for Early Stage Non-small Cell Lung Cancer

Surgery May Be Superior to Stereotactic Body RT for Early Stage Non-small Cell Lung Cancer

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SBRT provides excellent local control and an adequate safety profile, but there is a lack of data comparing SBRT to resection among patients eligible for surgery.

FDA Grants Breakthrough Therapy Designation to Ribociclib for HR+/HER2- Breast Cancer

FDA Grants Breakthrough Therapy Designation to Ribociclib for HR+/HER2- Breast Cancer

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FDA grants Breakthrough Therapy designation for ribociclib as an initial endocrine-based therapy for HR+/HER2- breast cancer in premenopausal or perimenopausal women.

2-Year Rituximab Maintenance Therapy Prolongs PFS in Elderly With CLL

2-Year Rituximab Maintenance Therapy Prolongs PFS in Elderly With CLL

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Investigators sought to determine the efficacy of 2-year rituximab maintenance therapy in elderly patients with CLL who achieve a complete response to abbreviated FCR induction therapy.

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