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Combination of Gemcitabine and New CHK1 Inhibitor Is Effective in Soft Tissue Sarcomas

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In a phase 1 clinical trial, the combination produces a significant and long-lasting response in patients with advanced disease including metastases to the peritoneum and lung.

Acupuncture Improves Postoperative Symptoms in Women Undergoing Surgery for Breast Cancer

Acupuncture Improves Postoperative Symptoms in Women Undergoing Surgery for Breast Cancer

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The effects of a 2-treatment course of acupuncture on pain, nausea, and anxiety and ability to cope among women undergoing mastectomy was compared with usual care.

USPSTF Continues Recommendations Against Thyroid Cancer Screening

USPSTF Continues Recommendations Against Thyroid Cancer Screening

Widespread routine thyroid cancer screening can lead to overdiagnosis and overtreatment, the USPSTF contends.

Cognitive Therapy Not More Effective Than Usual Care for Distress Reduction in Advanced PCa

Cognitive Therapy Not More Effective Than Usual Care for Distress Reduction in Advanced PCa

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Advanced prostate cancer is associated with substantial psychosocial morbidity; therefore, this study was conducted to evaluate whether mindfulness-based cognitive therapy reduces distress in this population.

FDA Approves Daratumumab Regimens for Relapsed Multiple Myeloma

FDA Approves Daratumumab Regimens for Relapsed Multiple Myeloma

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The US FDA has granted approval for additional indications for daratumumab for the treatment of patients with multiple myeloma who have received prior therapies.

Guidelines Issued for Prostate MRI After Negative Biopsy

Guidelines Issued for Prostate MRI After Negative Biopsy

Consensus statement presents guidelines for prostate magnetic resonance imaging (MRI) in patients with negative biopsy.

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

IH-induced exosomes from mice significantly promote TC1 malignant properties, according to a recent study.

Overall Risk of Second Primary Malignancies is Low in Multiple Myeloma

Overall Risk of Second Primary Malignancies is Low in Multiple Myeloma

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A panel of International Myeloma Working Group members  presents their review of current data on the potential host-, disease-, and treatment-related risk factors associated with the development of second primary malignancies in patients with multiple myeloma.

Vorinostat + Len-Dex Active in Lenalidomide-refractory Patients With Multiple Myeloma

Vorinostat + Len-Dex Active in Lenalidomide-refractory Patients With Multiple Myeloma

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In this single-center, open-label, phase 2b trial, researchers determined if adding vorinostat to lenadolimide and dexamethasome would improve outcomes for patients with multiple myeloma refractory to lenalidomide.

AYA Cancer Survivors More Likely to Have Mental Distress Than Healthy Individuals

AYA Cancer Survivors More Likely to Have Mental Distress Than Healthy Individuals

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Using the Kessler nonspecific mental/psychological distress scale, investigators examined whether AYA cancer survivor experienced greater mental distress and assessed their access to mental health care.

Fecal Occult Blood Test, Colonoscopy Useful for Detecting Dasatinib-induced Colitis

Fecal Occult Blood Test, Colonoscopy Useful for Detecting Dasatinib-induced Colitis

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Researchers examined the frequency of TKI-induced hemorrhagic colitis among patients with CML treated with dasatinib and evaluated the efficacy of screening with a fecal occult blood test followed by colonoscopy in this patient population.

Lipid-lowering Drugs May Confer Survival Benefit in Chronic Lymphocytic Leukemia

Lipid-lowering Drugs May Confer Survival Benefit in Chronic Lymphocytic Leukemia

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Abnormal lipid metabolism is observed in patients with CLL, prompting an investigation to determine if prevalence of metabolic syndrome is higher in patients with CLL and whether lipid-lowering medications impact survival.

Primary Cytoreductive Surgery Associated With Improved Survival in Ovarian Cancer

Primary Cytoreductive Surgery Associated With Improved Survival in Ovarian Cancer

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The benefits of primary cytoreductive surgery relative to neoadjuvant chemotherapy remain uncertain; therefore, researchers performed a retrospective data analysis to compare overall survival of surgery with that of neoadjuvant chemotherapy in advanced-stage epithelial ovarian cancer.

Pediatric Patients Continue to Experience High-Intensity EOL Care

Pediatric Patients Continue to Experience High-Intensity EOL Care

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Studies of end-of-life (EOL) care for pediatric patients have been limited to single institutions or lacked detailed clinical data. Therefore, researchers conducted a retrospective cohort study to examine predictor of, and trends in, high-intensity EOL care in this patient population.

Cancer Patients Benefit From Exercise Both During and After Treatment

Cancer Patients Benefit From Exercise Both During and After Treatment

Studies show better physical function and quality of life for cancer patients who do strength training or aerobic activity.

Depression May Contribute to Receipt of Inappropriate Breast Cancer Treatment

Depression May Contribute to Receipt of Inappropriate Breast Cancer Treatment

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An analysis of data from Danish women with early-stage breast cancer assessed women's risk of receiving nonguideline treatment for their disease if they had a prior diagnosis of depression or prior treatment with antidepressants.

Study Identifies Factors Associated With Platinum-induced Ototoxicity in Pediatric Cancer Survivors

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Large cohort study assesses the frequency of, and factors associated with, ototoxicity in childhood cancer survivors who received platinum agents without cranial irradiation.

Study Helps to Clarify Navigator Role in Colonoscopy Screening

Study Helps to Clarify Navigator Role in Colonoscopy Screening

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Survey data from patients receiving care at Boston Medical Center who were navigated for colonoscopy screening illustrates how patients value the services of oncology patient navigators.

CDC: Tobacco-Linked Cancers Still Make Up 40 Percent of All Cancers

CDC: Tobacco-Linked Cancers Still Make Up 40 Percent of All Cancers

Fewer people smoking, but cancer burden still high in the U.S.

Long-Term Health Not Improved for Childhood Cancer Survivors

Long-Term Health Not Improved for Childhood Cancer Survivors

Research shows only modest improvements in the physical or mental health of childhood cancer survivors in recent decades.

Continued Hydroxyurea vs Switching to Ruxolitinib for Polycythemia Vera

Continued Hydroxyurea vs Switching to Ruxolitinib for Polycythemia Vera

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Ruxolitinib is proven superior to best available therapy for polycythemia vera with inadequate response or intolerance of hydroxyurea. This study evaluates the impact of continued hydroxyurea vs switching to ruxolitinib on disease-related symptom burden.

Daratumumab To Be Evaluated With Carfilzomib in Multiple Myeloma

Daratumumab To Be Evaluated With Carfilzomib in Multiple Myeloma

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Amgen talks about its collaboration with Janssen Biotech Inc on clinical trials that assess the combination of carfilzomib (Kyprolis) with daratumumab (Darzalex) in patients with multiple myeloma.

Vaginal Ring/Cream May Be Feasible for Urogenital Atrophy

Vaginal Ring/Cream May Be Feasible for Urogenital Atrophy

The feasibility of an estradiol-releasing vaginal ring vs intravaginal testosterone cream for women with HR-positive stage I to III breast cancer using aromatase inhibitors who reported vaginal dryness, decreased libido, or dyspareunia is evaluated in a phase 2 study.

'Just Bag It' Campaign Aims to Promote Safe Vincristine Handling

'Just Bag It' Campaign Aims to Promote Safe Vincristine Handling

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The NCCN campaign was developed to ensure the proper administration of vincristine and to render it impossible to accidentally administer the medication into the spinal fluid.

Hospital Volume Linked to Odds of Appropriate Breast Cancer Locoregional Treatment

Hospital Volume Linked to Odds of Appropriate Breast Cancer Locoregional Treatment

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Investigators examined the extent to which hospital volume explains variations in diagnosis and treatment of breast cancer.

Prediagnostic Wine Consumption May Improve Survival After CRC

Prediagnostic Wine Consumption May Improve Survival After CRC

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A possible association between moderate to heavy alcohol consumption has been shown in previous studies. In this study, investigators examined the relationship between alcohol consumption and colorectal cancer survival remains unclear.

Metabolic Syndrome Associated With Increased Risk of Esophageal Cancer in Older Patients

Metabolic Syndrome Associated With Increased Risk of Esophageal Cancer in Older Patients

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A retrospective evaluation investigated the association between risk of esophageal cancer, metabolic syndrome, Barrett esophagus, and GERD in older persons.

Second Opinions Rarely Change Prostate Cancer Decisions

Second Opinions Rarely Change Prostate Cancer Decisions

The impact of additional opinions on patient decision-making is limited.

Higher Protein Intake May Modestly Improve Breast Cancer Survival

Higher Protein Intake May Modestly Improve Breast Cancer Survival

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An analysis of data from women with stage I to III breast cancer investigated the potential association between protein intake and survival.

How We Developed a New Protocol for Treatment of Urethral Carcinoma

How We Developed a New Protocol for Treatment of Urethral Carcinoma

Faced with a harsh treatment option, a patient with genitourinary cancer helps create a treatment plan that preserves his self-image.

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