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CYCLOSET
Diabetes
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Drug Name:

CYCLOSET Rx

Generic Name and Formulations:
Bromocriptine mesylate (micronized) 0.8mg; tabs.

Company:
VeroScience, LLC

Therapeutic Use:

Indications for CYCLOSET:

Adjunct to diet and exercise, to improve glycemic control in type 2 diabetes.

Limitations Of use:

Not for treating type 1 diabetes or ketoacidosis. Limited efficacy data in combination with thiazolidinediones. Efficacy has not been confirmed in combination with insulin.

Adult:

Take with food in the AM, within 2hrs of waking. Initially 0.8mg once daily; may increase by 0.8mg per week as tolerated until max 4.8mg/day. Usual range: 1.6–4.8mg/day. Concomitant moderate CYP3A4 inhibitors (eg, erythromycin): max 1.6mg once daily. Concomitant strong CYP3A4 inhibitors (eg, azole antimycotics, protease inhibitors): avoid.

Children:

Not established.

Contraindications:

Syncopal migraines. Nursing mothers. Allergy to ergot-related drugs.

Warnings/Precautions:

Monitor orthostatic vital signs initially and periodically during therapy. Severe psychotic disorders: not recommended. Renal or hepatic impairment. Pregnancy (Cat.B).

Interactions:

See Adult. Concomitant selective 5-HT1B agonists (eg, sumatriptan), sympathomimetic drugs >10 days, ergot-related drugs within 6hrs, other dopamine agonists and antagonists, including neuroleptics (eg, clozapine, olanzapine, ziprasidone) and metoclopramide: not recommended. Potentiated by CYP3A4 inhibitors and antagonized by CYP3A4 inducers (eg, rifampin, dexamethasone). Potentiates antihypertensives; caution. May potentiate highly protein bound drugs (eg, salicylates, sulfonamides, chloramphenicol, probenecid).

Pharmacological Class:

Dopamine agonist (ergot deriv).

Adverse Reactions:

Nausea, vomiting, fatigue, dizziness, headache; hypotension, syncope, somnolence, hypoglycemia.

How Supplied:

Tabs—200

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