Cutaneous HPV linked to squamous cell carcinoma

Share this article:

Squamous cell carcinoma (SCC) was positively associated with antibodies to several types of cutaneous human papillomavirus (HPV) in a case control study.

Cutaneous HPV infection, which differs from the mucosal HPV infection associated with cervical cancer, has been suspected of being a risk factor for SCC. Dana E. Rollison, PhD, of the Department of Cancer Epidemiology at the H. Lee Moffitt Cancer Center & Research Institute in Tampa, Florida, and colleagues investigated the association by studying 173 SCC cases and 300 controls who screened negative for skin cancer at a university dermatology clinic.

As the team reported in Cancer Epidemiology, Biomarkers & Prevention, antibodies against cutaneous HPV types in genera alpha, beta, gamma, mu, and nu in participants' blood samples were measured. In addition, tumor tissue from 159 of the SCC cases was tested for the presence of cutaneous HPV infection. The measuring of cutaneous HPV types in five different genera and the investigating of correlations between cutaneous HPV antibodies in the blood and HPV infection in the tumor made this study unique, pointed out Rollison in a statement issued by the Moffitt Cancer Center.

The researchers found that SCC was positively associated with seropositivity to any genus-beta HPV type. Type-specific associations with SCC were observed for HPV type 10 in genus alpha and HPV types 8 and 17 in genus beta. Additional associations were found between antibodies to beta HPV types 5 and 24 when SCC cases with those same HPV types in their tumors were compared with controls.

Identifying the role of cutaneous HPV infection in SCC may lead to improved characterization of high-risk individuals and the development of novel prevention strategies, noted Rollison and associates.

Share this article:
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs

More in Web Exclusives

Postmenopausal breast cancer risk drops off after starting regular physical activity

Postmenopausal women who in the past 4 years had undertaken regular physical activity equivalent to at least 4 hours of walking per week had a lower risk for invasive breast cancer compared with women who exercised less

Mutations in the PALB2 gene increases risk of breast cancer by age ...

The PALB2 gene is potentially one of the most important genes associated with breast cancer after the BRCA1/2 genes.

Existing drug offers new hope in a subtype of pancreatic cancer

A new use for an old drug shrinks a particular type of pancreatic cancer and stops it from spreading, according to new research.