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CRINONE
Infertility
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Drug Name:

CRINONE Rx

Generic Name and Formulations:
Progesterone (micronized) 8% (90mg/applicatorful); vaginal gel; contains mineral oil.

Company:
Allergan

Therapeutic Use:

Indications for CRINONE:

Progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency.

Adult:

Supplementation: 1 applicatorful intravaginally once daily. Replacement: 1 applicatorful intravaginally twice daily. If pregnancy occurs, may continue treatment until placental autonomy is achieved (10–12 weeks).

Children:

Not applicable.

Contraindications:

Undiagnosed vaginal bleeding. Breast or genital carcinoma. Liver dysfunction or disease. Missed abortion. Thrombophlebitis or thromboembolic disorders.

Warnings/Precautions:

Conditions aggravated by fluid retention. Depression. Include Pap smear with pretreatment exam. Discontinue if signs of thrombotic disorders (eg, thrombophlebitis, cerebrovascular disorders, pulmonary embolism, retinal thrombosis) occur. Pregnancy: see literature. Nursing mothers.

Interactions:

Allow at least 6 hours between administration of this and other vaginally-administered products.

Adverse Reactions:

Mastodynia, constipation, somnolence, GI upset, headache, abdominal/perineal pain, nervousness, cramps, nocturia, depression, decreased libido, arthralgia, bloating, pain, vaginal candidiasis/discharge, dizziness, dyspareunia, pruritus genital, allergy, fatigue, urinary tract infection, others.

How Supplied:

Prefilled applicators—18

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