ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

COMBIVIR
Viral infections
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

COMBIVIR Rx

Generic Name and Formulations:
Lamivudine 150mg, zidovudine 300mg; scored tabs.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for COMBIVIR:

HIV-1 infection.

Adults and Children:

<30kg: not recommended. ≥30kg: 1 tab twice daily. Hepatic or renal impairment (CrCl <50mL/min): not recommended; use individual components.

Warnings/Precautions:

Risk of hematologic toxicity/bone marrow suppression; monitor CBCs esp. in advanced HIV-1 disease; interrupt dose if anemia or neutropenia occurs. Myopathy with prolonged zidovudine use. Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Not for treating hepatitis B; monitor patients co-infected with HBV for at least several months after stopping treatment (discontinuing may exacerbate HBV infection). History of pancreatitis. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See full labeling. Concomitant stavudine, doxorubicin, ribavirin, emtricitabine, other forms of lamivudine or zidovudine: not recommended. Increased hematologic toxicity with ganciclovir, interferon alpha, other bone marrow suppressants or cytotoxic drugs. TMP/SMX, nelfinavir may potentiate lamivudine. Atovaquone, clarithromycin, fluconazole, methadone, nelfinavir, probenecid, rifampin, ritonavir, valproic acid may affect zidovudine levels; monitor. Monitor for treatment-associated toxicities (eg, hepatic decompensation) with interferon-alpha with or without ribavirin.

Pharmacological Class:

Nucleoside analogues (reverse transcriptase inhibitors).

Adverse Reactions:

Headache, nausea, malaise, fatigue, nasal symptoms, diarrhea, cough; neutropenia, anemia, lactic acidosis, severe hepatomegaly with steatosis, fat redistribution, myopathy, myositis, immune reconstitution syndrome, post-treatment exacerbation of hepatitis B, pancreatitis (discontinue if occurs).

Note:

Register pregnant patients exposed to lamivudine by calling (800) 258-4263.

How Supplied:

Tabs—60

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs