Combination Therapy

Combination of Gemcitabine and New CHK1 Inhibitor Is Effective in Soft Tissue Sarcomas

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In a phase 1 clinical trial, the combination produces a significant and long-lasting response in patients with advanced disease including metastases to the peritoneum and lung.

Panobinostat, Bortezomib, Thalidomide Efficacious in Relapsed Myeloma

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In this study, researchers sought to improve the safety of panobinostat plus bortezomib and dexamethasone for relapsed or relapsed and refractory multiple myeloma.

Olaratumab in Combo With Doxorubicin Approved for Soft Tissue Sarcoma

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The US FDA granted accelerated approval to olaratumab (Lartruvo) in combination with doxorubicin for the treatment of certain patients with soft tissue sarcoma.

Daratumumab With Len-Dex Prolongs PFS in R/R Multiple Myeloma

Daratumumab With Len-Dex Prolongs PFS in R/R Multiple Myeloma

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Adding daratumumab to lenalidomide and dexamethasone significantly prolonged progression-free survival compared with lenalidomide plus dexamethasone alone in patients with relapsed or refractory multiple myeloma.

Adding Bevacizumab to Adjuvant Capecitabine Not Effective for mCRC

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The combination of adjuvant bevacizumab and capecitabine failed to improve disease-free survival compared with capecitabine alone in patients with mCRC who had undergone potentially curative surgery.

Ezh2 Inhibitors May Offer Cure for Chronic Myelogenous Leukemia

Ezh2 Inhibitors May Offer Cure for Chronic Myelogenous Leukemia

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Inhibition of the protein Ezh2 causes chronic myelogenous leukemia (CML) stem cells to die. Adding drugs that target this protein to imatinib (Gleevec) or other BCR-ABL blockers could result in a cure for this disease.

Addition of Elotuzumab to Bortezomib/Dexamethasone Improves Survival in Relapsed/Refractory Multiple Myeloma

Addition of Elotuzumab to Bortezomib/Dexamethasone Improves Survival in Relapsed/Refractory Multiple Myeloma

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The addition of elotuzumab to bortezomib/dexamethasone appears to increase progression-free survival in relapsed/refractory multiple myeloma (RRMM).

Chemoradiation Combination Could Preserve Larynx in Patients With Laryngeal and Hypolaryngeal Cancer

Chemoradiation Combination Could Preserve Larynx in Patients With Laryngeal and Hypolaryngeal Cancer

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Researchers assessed the rates of laryngeal preservation and laryngectomy-free survival in patients with laryngeal or hypopharyngeal cancer who received the monoclonal antibody cetuximab and radiation therapy or radiation therapy alone.

Immunotherapy Combination is Effective in Colorectal Cancer

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Cbimetinib and atezolizumab was well tolerated and demonstrated encouraging clinical activity in microsatellite stable colorectal cancer (CRC).

Novel Nanoparticle Achieves Concomitant Tumor Cell Death and Resistance Suppression

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Resistance to therapy through adaptation poses a major hurdle for cancer therapy. Bioengineers addressed this by creating a single nanoparticle that comprises a synergistic drug pair that shuts down mechanisms of resistance to a degree that has not been previously achieved.

DECT Trial Results Show Trastuzumab Plus Anthracyclines Are Efficacious in HER2+ Breast Cancer

DECT Trial Results Show Trastuzumab Plus Anthracyclines Are Efficacious in HER2+ Breast Cancer

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Results from the DECT trial indicate that a combination of epirubicin and trastuzumab improved outcomes in patients with HER2-positive breast cancer.

Disease-Free Status Is Achieved by Combining Immunotherapy Treatments in Patient With Metastatic Melanoma

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A patient with refractory metastatic melanoma was successfully treated with a novel combination of 2 different types of immunotherapy.

Daratumumab in Combination With Standard-of-Care Treatment Significantly Improves Outcomes in Patients With Multiple Myeloma

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Daratumumab in combination with the standard-of-care treatment regimen reduced risk of disease progression or death by 63% compared with the standard-of-care regimen alone in patients with multiple myeloma who had received at least 1 prior line of therapy.

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

Novel Approach Uses Ultrasound to Enhance Efficacy of Chemotherapy in Pancreatic Cancer

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Combining a laboratory ultrasound technique called sonoporation with the commercially available chemotherapy compound gemcitabine increases the porosity of pancreatic cells with microbubbles and helps get the drug into cancer cells.

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

Chemotherapy and Radiation Prior to Surgery Improves Outcomes in Patients With Pancreatic Cancer

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Despite the increased risk, patients whose pancreatic cancer tumor has grown to encompass critical blood vessels can be candidates for surgery. Data on efforts to fine-tune a protocol for these patients were presented at the SSAT 57th Annual Meeting.

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

Adjuvant Gemcitabine/Capecitabine: New Standard of Care for Resected Pancreatic Cancer

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Adjuvant gemcitabine plus capecitabine significantly improved overall survival compared with gemcitabine monotherapy in patients with pancreatic ductal adenocarcinoma, according to results of the ESPAC-4 trial presented at the ASCO 2016 Annual Meeting.

Adding Doxorubicin to Sorafenib Does Not Improve Overall Survival in Hepatocellular Carcinoma

Adding Doxorubicin to Sorafenib Does Not Improve Overall Survival in Hepatocellular Carcinoma

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In patients with advanced hepatocellular carcinoma (HCC), adding doxorubicin to sorafenib did not improve overall survival or progression-free survival and resulted in higher toxicity compared to sorafenib alone, results from a phase 3 study presented at the ASCO 2016 Annual Meeting have shown.

Daratumumab + Bortezomib/Dexamethasone: Reduced Risk of Disease Progression Seen in Relapsed or Refractory Multiple Myeloma

Daratumumab + Bortezomib/Dexamethasone: Reduced Risk of Disease Progression Seen in Relapsed or Refractory Multiple Myeloma

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Adding daratumumab to bortezomib and dexamethasone was associated with a 61% reduction in risk of disease progression in patients with relapsed or refractory multiple myeloma (RRMM), according to results of the phase 3 CASTOR study presented in a plenary session at the ASCO 2016 Annual Meeting.

Alemtuzumab + CHOP for Peripheral T Cell Lymphoma: Higher Remission, But Not Survival

Alemtuzumab + CHOP for Peripheral T Cell Lymphoma: Higher Remission, But Not Survival

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When added to the CHOP regimen, alemtuzumab increases remission rates in elderly patients with peripheral T cell lymphoma, final analysis of the international ACT-2 phase 3 trial presented at the ASCO 2016 Annual Meeting has shown.

Nimotuzumab + Radiotherapy Less Toxic Than Cisplatin + Radiotherapy for Stage III/IVB Nasopharyngeal Cancer

Nimotuzumab + Radiotherapy Less Toxic Than Cisplatin + Radiotherapy for Stage III/IVB Nasopharyngeal Cancer

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Patients with locally advanced nasopharyngeal cancer concurrently treated with nimotuzumab and radiotherapy had similar rates of progression-free and overall survival to those treated with cisplatin and radiotherapy, but with significantly fewer GI and hematologic toxicities, according to phase 3 trial results presented at the ASCO 2016 Annual Meeting.

Triple-Drug Therapy Produces Response in Triple-Negative Breast Cancer, Mouse Study Shows

Triple-Drug Therapy Produces Response in Triple-Negative Breast Cancer, Mouse Study Shows

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A cocktail of 3 drugs shrank triple-negative breast cancer (TNBC) by killing off cancer cells and halting new tumor growth, a new study conducted in mice and lab-grown human cells has shown.

Combination of Radiation and Immunotherapy Shows Promise in Melanoma

Combination of Radiation and Immunotherapy Shows Promise in Melanoma

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Combining radiation treatments with a new generation of immunotherapies is showing promise in the treatment of melanoma, according to a recent review.

Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy

Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy

[Journal of Gastrointestinal Oncology] This research reviews the case history of a patient with stage IVB pancreatic adenocarcinoma initially treated with gemcitabine and erlotinib who stopped therapy after 3 months without achieving a response and was switched to a different and effective combination strategy.

Radiotherapy Plus Hormone Therapy Improves Long-term Survival for Patients With Prostate Cancer

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Radiotherapy in combination with anti-androgen hormone therapy halves the risk of death from prostate cancer 15 years after diagnosis compared with hormone therapy alone.

Adding Two Inhibitors Enhances Effectiveness of Tamoxifen in ER-positive Breast Cancer

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Combining 2 existing chemotherapy drugs, a DNMT1 inhibitor and a histone deacetylase inhibitor, reduced the numbers of cancer stem cells and improved survival in a mouse model.

Immunotherapy-radiation Combination Destroys Tumors Both Within and Outside the Radiation Field

Immunotherapy-radiation Combination Destroys Tumors Both Within and Outside the Radiation Field

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Adding an immune system-strengthening compound to radiation therapy can extend the immune response that the radiation therapy induces, so that both irradiated tumor sites and tumors outside the radiation field are affected.

Age Affects Outcomes After Mastectomy or Breast-conserving Therapy for Early Stage Breast Cancer

Age Affects Outcomes After Mastectomy or Breast-conserving Therapy for Early Stage Breast Cancer

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For women younger than 45 years with early stage breast cancer that has not spread to the lymph nodes, opting for breast-conserving therapy with RT was associated with higher risk of local recurrence over 20 years compared with mastectomy and no RT.

New Drug Combination Before Surgery May Improve Outcomes for Advanced HER2+ Breast Cancer

New Drug Combination Before Surgery May Improve Outcomes for Advanced HER2+ Breast Cancer

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Combining trastuzumab emtansine (T-DM1) and pertuzumab before surgery was more beneficial than the combination of paclitaxel plus trastuzumab for patients with HER2-positive invasive breast cancer.

Necitumumab With Chemotherapy Beneficial for Patients With EGFR-expressing NSCLC

Necitumumab With Chemotherapy Beneficial for Patients With EGFR-expressing NSCLC

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The most benefit from adding necitumumab to chemotherapy with gemcitabine and cisplatin occurred for patients whose advanced squamous NSCLC expressed EGFR.

Chemotherapy and Radiotherapy Combination Prolongs Survival in Low-grade Glial Brain Cancer

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The addition of chemotherapy to radiation therapy prolonged survival in adults with grade 2 glial brain tumors.

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