Study results presented at 2018 ASCO Annual Meeting demonstrated effectiveness of ado-trastuzumab emtansine in non-breast non-gastric HER2-amplified cancers.
1. Patients with advanced adenomas identified on flex sigmoidoscopy had a significantly increased risk of death from colorectal cancer (CRC) compared to those with no adenomas. 2. There was no difference in cumulative CRC incidence in patients with nonadvanced adenomas as compared to those with no adenomas. Evidence Rating: 1 (Excellent) Study Rundown: Colorectal cancer 
[Gastrointestinal Cancer: Targets and Therapy] This review presents the most up-to-date molecular, clinical, and therapeutic data, including an overview of a current phase 3 study assessing the efficacy of simultaneous BRAF, EGFR, and MEK inhibition among patients with BRAFV600E-mutant CRC.
Researchers evaluated survival in patients with colon cancer, according to the type of insurance the patients held.
A review of the literature on follow-up after positive screening results led researchers to a consensus opinion on timing of diagnostic tests for 4 cancers: breast, cervical, colorectal, and lung.
A cross-sectional analysis evaluated the impact of hope and optimism on different facets of psychological distress among patients with advanced melanoma, colorectal, lung, or gastrointestinal cancers.
1. Sigmoidoscopy was associated with a reduction in the prevalence of colon cancer mortality in men. 2. Sigmoidoscopy did not appear to have a significant protective effect for women with respect to decreasing the rates of colorectal cancer. Evidence Rating Level: 1 (Excellent) Study Rundown: Colorectal cancer (CRC) is one of the most common cancers 
Researchers conducted a case-control study to determine whether colonoscopy is associated with decreased CRC mortality in veterans and whether its effect differs by anatomical location of CRC.
A prospective study assessing the outcomes of a cohort of participants in the CALGB 89803 study determined the effect of following the American Cancer Society guidelines on survival for persons with colon cancer.
BEACON CRC Safety Lead-in Study suggests safety and efficacy of triplet combination therapy for treatment of metastatic colorectal cancerApril 13, 2018
1. BEACON CRC is a multicenter, randomized, phase 3 clinical trial evaluating the triplet combination of binimetinib (BINI, a MEK inhibitor) + encorafenib (ENCO, a BRAF inhibitor) + cetuximab (CETUX, an EGFR antibody) for the treatment of metastatic colorectal cancer. 2. Preliminary analysis of the Safety Lead-in Study for the BEACON CRC reveals that the 
1. Enrollment in Medicare Shared Savings Program (MSSP) Accountable Care Organizations (ACO) was associated with a decrease in breast cancer screening, increase in colorectal cancer screening, and decreased prostate cancer screening, reflecting more appropriate utilization of screening tests. 2. Changes in breast and colon cancer screening were strongly influenced by participant age. Evidence Rating Level: 
Results of the phase 3 AXEPT study were used to determine the noninferiority of a modified XELIRI regimen vs a FOLFIRI regimen in terms of overall survival among patients with metastatic colorectal cancer (mCRC).
Fifty-three percent of intervention participants used app to self-order a colorectal screening test.
1. Colonoscopy in veterans was associated with reduced mortality from both left and right-sided colorectal cancer. 2. Mortality was reduced by 61% in patients screened by colonoscopy. Evidence Rating Level: 2 (Good) Study Rundown: Colorectal cancer (CRC) screening serves as a critical element of CRC prevention and management. To date, colonoscopy remains the gold standard 
1. Digital health intervention resulted in significantly higher colon cancer screening rates among participants. 2. No statistically significant relationship was observed between the digital health intervention and health literacy, income, or race and ethnicity. Evidence Rating Level: 1 (Excellent) Study Rundown: Colorectal cancer (CRC) is one of the leading causes of cancer in both men 
Investigators conducted a prospective observational study involving patients with stage III colon cancer to examine the correlation of nut intake with cancer mortality.
Analysis revealed factors that contribute to reduced dietary intake among hospitalized patients with colorectal cancer.
Investigators examined correlations between an empirical dietary inflammatory pattern (EDIP) score and colorectal cancer risk.
Safety and efficacy of atezolizumab with cobimetinib for heavily pretreated metastatic CRC was demonstrated in a phase 1b study that was presented at the 2018 Gastrointestinal Cancers Symposium.
Study results presented at the 2018 Gastrointestinal Cancers Symposium demonstrated the sensitivity and specificity of the CMx biomimetic platform, a novel approach to detecting CRC and precancerous lesions that could improve screening rates.
No additional risk of colorectal cancer was noted among women treated with aromatase inhibitors (AIs) following a median follow-up of 2.4 and 2.9 years.
New research on the benefits of high-fiber diets for CRC survivors took its findings one step further and identified the type of fiber consumed and which provided better benefits.
Increasing fiber consumption after diagnosis may lower risk of all-cause, CRC-specific mortality.
A small study of 50 patients undergoing FOLFOX for CRC determined if adding aprepitant to standard antiemetic prophylactic treatment would improve CINV in this patient population.
An analysis of 23 studies focused on interventions with the potential to improve follow-up colonoscopy completion rates found that navigation programs are more effective than other interventions studied.
Investigators sought to determine clinical and cost effectiveness of additional colonoscopy screening in patients undergoing FIT screening for colorectal cancer.
Bevacizumab-awwb is a recombinant IgG1 monoclonal antibody that works by binding to vascular endothelial growth factor (VEGF) and inhibits angiogenesis.
Sarcopenia is significantly associated with dose reductions but not with dose-limiting toxicities at initiation of CAPOX-B reinduction therapy in patients with mCRC, researchers reported at ESMO 2017 Congress.
A newly developed patient education resource helps nurses educate patients with colorectal cancer about biomarker testing and counsel them on the significance of the results.
Researchers examined the impact of exercise and low body fat mass on recurrence of colorectal polyps among survivors of colorectal cancer.
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