Colorectal Cancer

Ado-trastuzumab Emtansine Effective in HER2 Amplified Non-breast, Non-gastric Cancers

Ado-trastuzumab Emtansine Effective in HER2 Amplified Non-breast, Non-gastric Cancers

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Study results presented at 2018 ASCO Annual Meeting demonstrated effectiveness of ado-trastuzumab emtansine in non-breast non-gastric HER2-amplified cancers.

Patients with advanced adenomas are at increased risk of developing colorectal cancer

1. Patients with advanced adenomas identified on flex sigmoidoscopy had a significantly increased risk of death from colorectal cancer (CRC) compared to those with no adenomas. 2. There was no difference in cumulative CRC incidence in patients with nonadvanced adenomas as compared to those with no adenomas. Evidence Rating: 1 (Excellent) Study Rundown: Colorectal cancer []

Emerging Treatment Options for BRAF-mutant Colorectal Cancer

Emerging Treatment Options for BRAF-mutant Colorectal Cancer

[Gastrointestinal Cancer: Targets and Therapy] This review presents the most up-to-date molecular, clinical, and therapeutic data, including an overview of a current phase 3 study assessing the efficacy of simultaneous BRAF, EGFR, and MEK inhibition among patients with BRAFV600E-mutant CRC.

Insurance Type Influences Colon Cancer Survival

Insurance Type Influences Colon Cancer Survival

Researchers evaluated survival in patients with colon cancer, according to the type of insurance the patients held.

Cancer Screening Follow-up: Enabling Timely Diagnosis, Treatment

Cancer Screening Follow-up: Enabling Timely Diagnosis, Treatment

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A review of the literature on follow-up after positive screening results led researchers to a consensus opinion on timing of diagnostic tests for 4 cancers: breast, cervical, colorectal, and lung.

Hope, Optimism Reduce Psychological Distress in Advanced Cancer

Hope, Optimism Reduce Psychological Distress in Advanced Cancer

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A cross-sectional analysis evaluated the impact of hope and optimism on different facets of psychological distress among patients with advanced melanoma, colorectal, lung, or gastrointestinal cancers.

Sigmoidoscopy reduces colon cancer risk for men, but not women

1. Sigmoidoscopy was associated with a reduction in the prevalence of colon cancer mortality in men. 2. Sigmoidoscopy did not appear to have a significant protective effect for women with respect to decreasing the rates of colorectal cancer. Evidence Rating Level: 1 (Excellent) Study Rundown: Colorectal cancer (CRC) is one of the most common cancers []

Screening Colonoscopy Improves CRC-Related Mortality in Veterans

Screening Colonoscopy Improves CRC-Related Mortality in Veterans

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Researchers conducted a case-control study to determine whether colonoscopy is associated with decreased CRC mortality in veterans and whether its effect differs by anatomical location of CRC.

Following ACS Guidelines Shown to Improve Outcomes for Colon Cancer Survivors

Following ACS Guidelines Shown to Improve Outcomes for Colon Cancer Survivors

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A prospective study assessing the outcomes of a cohort of participants in the CALGB 89803 study determined the effect of following the American Cancer Society guidelines on survival for persons with colon cancer.

BEACON CRC Safety Lead-in Study suggests safety and efficacy of triplet combination therapy for treatment of metastatic colorectal cancer

1. BEACON CRC is a multicenter, randomized, phase 3 clinical trial evaluating the triplet combination of binimetinib (BINI, a MEK inhibitor) + encorafenib (ENCO, a BRAF inhibitor) + cetuximab (CETUX, an EGFR antibody) for the treatment of metastatic colorectal cancer. 2. Preliminary analysis of the Safety Lead-in Study for the BEACON CRC reveals that the []

Accountable Care Organizations linked to modest increase in appropriate cancer screening

1. Enrollment in Medicare Shared Savings Program (MSSP) Accountable Care Organizations (ACO) was associated with a decrease in breast cancer screening, increase in colorectal cancer screening, and decreased prostate cancer screening, reflecting more appropriate utilization of screening tests. 2. Changes in breast and colon cancer screening were strongly influenced by participant age. Evidence Rating Level: []

Modified XELIRI Noninferior to FOLFIRI for OS in Metastatic Colorectal Cancer

Modified XELIRI Noninferior to FOLFIRI for OS in Metastatic Colorectal Cancer

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Results of the phase 3 AXEPT study were used to determine the noninferiority of a modified XELIRI regimen vs a FOLFIRI regimen in terms of overall survival among patients with metastatic colorectal cancer (mCRC).

Colorectal Cancer Screening Rate Increased by Digital Self-Ordering

Colorectal Cancer Screening Rate Increased by Digital Self-Ordering

Fifty-three percent of intervention participants used app to self-order a colorectal screening test.

Colonoscopy significantly reduces mortality from colorectal cancer in Veterans Affairs study

1. Colonoscopy in veterans was associated with reduced mortality from both left and right-sided colorectal cancer. 2. Mortality was reduced by 61% in patients screened by colonoscopy. Evidence Rating Level: 2 (Good) Study Rundown: Colorectal cancer (CRC) screening serves as a critical element of CRC prevention and management. To date, colonoscopy remains the gold standard []

iPad app that allows patients to order tests doubles colon cancer screening rates in study

1. Digital health intervention resulted in significantly higher colon cancer screening rates among participants. 2. No statistically significant relationship was observed between the digital health intervention and health literacy, income, or race and ethnicity. Evidence Rating Level: 1 (Excellent) Study Rundown: Colorectal cancer (CRC) is one of the leading causes of cancer in both men []

Increased Nut Consumption May Reduce Colon Cancer Recurrence, Death

Increased Nut Consumption May Reduce Colon Cancer Recurrence, Death

Investigators conducted a prospective observational study involving patients with stage III colon cancer to examine the correlation of nut intake with cancer mortality.

Recognizing Reduced Dietary Intake in Hospitalized Patients With Colorectal Cancer

Recognizing Reduced Dietary Intake in Hospitalized Patients With Colorectal Cancer

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Analysis revealed factors that contribute to reduced dietary intake among hospitalized patients with colorectal cancer.

Proinflammatory Diet Associated With Increased Colorectal Cancer Risk

Proinflammatory Diet Associated With Increased Colorectal Cancer Risk

Investigators examined correlations between an empirical dietary inflammatory pattern (EDIP) score and colorectal cancer risk.

Partial Response Achieved With Atezolizumab, Cobimetinib in Pretreated CRC

Partial Response Achieved With Atezolizumab, Cobimetinib in Pretreated CRC

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Safety and efficacy of atezolizumab with cobimetinib for heavily pretreated metastatic CRC was demonstrated in a phase 1b study that was presented at the 2018 Gastrointestinal Cancers Symposium.

Novel Approach Can Improve Both Colorectal Cancer Screening Outcomes and Adherence

Novel Approach Can Improve Both Colorectal Cancer Screening Outcomes and Adherence

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Study results presented at the 2018 Gastrointestinal Cancers Symposium demonstrated the sensitivity and specificity of the CMx biomimetic platform, a novel approach to detecting CRC and precancerous lesions that could improve screening rates.

Aromatase Inhibitor Use Does Not Increase Risk of Colorectal Cancer

Aromatase Inhibitor Use Does Not Increase Risk of Colorectal Cancer

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No additional risk of colorectal cancer was noted among women treated with aromatase inhibitors (AIs) following a median follow-up of 2.4 and 2.9 years.

Colorectal Cancer and Dietary Fiber: Source Is More Important Than Amount

Colorectal Cancer and Dietary Fiber: Source Is More Important Than Amount

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New research on the benefits of high-fiber diets for CRC survivors took its findings one step further and identified the type of fiber consumed and which provided better benefits.

Fiber Associated With Reduced Mortality in Those With Colorectal Cancer

Fiber Associated With Reduced Mortality in Those With Colorectal Cancer

Increasing fiber consumption after diagnosis may lower risk of all-cause, CRC-specific mortality.

Aprepitant Plus Standard Antiemetic Regimen Prevents CINV With FOLFOX for CRC

Aprepitant Plus Standard Antiemetic Regimen Prevents CINV With FOLFOX for CRC

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A small study of 50 patients undergoing FOLFOX for CRC determined if adding aprepitant to standard antiemetic prophylactic treatment would improve CINV in this patient population.

Navigation Programs Most Effective in Increasing Follow-up Colonoscopy

Navigation Programs Most Effective in Increasing Follow-up Colonoscopy

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An analysis of 23 studies focused on interventions with the potential to improve follow-up colonoscopy completion rates found that navigation programs are more effective than other interventions studied.

Surveillance Plus FIT for CRC Screening: Additional Costs Not Justified by Benefits

Surveillance Plus FIT for CRC Screening: Additional Costs Not Justified by Benefits

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Investigators sought to determine clinical and cost effectiveness of additional colonoscopy screening in patients undergoing FIT screening for colorectal cancer.

FDA Grants Approval to Bevacizumab-awwb as First Biosimilar for Anticancer Therapy

FDA Grants Approval to Bevacizumab-awwb as First Biosimilar for Anticancer Therapy

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Bevacizumab-awwb is a recombinant IgG1 monoclonal antibody that works by binding to vascular endothelial growth factor (VEGF) and inhibits angiogenesis.

Sarcopenia Affects Dose in Reinduction Therapy for Metastatic Colorectal Cancer

Sarcopenia Affects Dose in Reinduction Therapy for Metastatic Colorectal Cancer

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Sarcopenia is significantly associated with dose reductions but not with dose-limiting toxicities at initiation of CAPOX-B reinduction therapy in patients with mCRC, researchers reported at ESMO 2017 Congress.

Educational Program Explains Biomarker Testing for Colorectal Cancer

Educational Program Explains Biomarker Testing for Colorectal Cancer

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A newly developed patient education resource helps nurses educate patients with colorectal cancer about biomarker testing and counsel them on the significance of the results.

Colorectal Cancer Recurrence Lower in Survivors Who Exercise

Colorectal Cancer Recurrence Lower in Survivors Who Exercise

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Researchers examined the impact of exercise and low body fat mass on recurrence of colorectal polyps among survivors of colorectal cancer.

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