Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic CancerMay 24, 2016
Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.
The experimental treatment LOXO-101 led to remarkable improvement for a 20-month-old girl whose rare pediatric cancer did not respond to surgery or chemotherapy.
Tumors of varied types of genetically defined cancer were significantly reduced by the drug LOXO-101, according to phase 1 study results.
A research unit created by oncology nurses trains nurses to provide high quality care to patients in oncology clinical trials.
A clinical trial infusion nurse orientation improves training for nurses so they can better care for patients participating in investigational trials.
Cancer stem cells that drive tumor growth were halved by MEDI-551, an experimental antibody treatment for multiple myeloma, according to results of a small preliminary clinical trial.
Shortened Radiation Therapy Schedule No Worse Than Conventional Radiotherapy in Low-Risk Prostate CancerApril 22, 2016
Treatment with a hypofractionated radiotherapy (HRT) schedule achieved similar efficacy as treatment with the longer, conventional RT (CRT) schedule in men with low-risk prostate cancer.
Adding panobinostat to radiotherapy appears safe, tolerable, and has preliminary efficacy for treating recurrent high-grade gliomas.
The social media platform Twitter could develop into a useful tool for communicating with the public about cancer clinical trials and for recruiting participants.
Combination therapy with durvalumab and tremelimumab demonstrated antitumor activity in 23% of 102 patients with lung cancer in a phase 1b trial, and toxicity was manageable.
No evidence that interferon is necessary or helpful in cases of melanoma with minimal metastasis to the lymph nodes, according to the final results of the Sunbelt Melanoma Trial.
Tumor growth may be substantially slowed by the novel therapy 177Lutetium-DOTATATE (Lutathera), according to early results from a phase III study of patients with previously treated, advanced midgut neuroendocrine tumors.
Optical probes that make cancer cells glow and improve surgical tumor removal are in phase I and II clinical trials in humans. The probes could be commonplace in the next 5 to 10 years, hypothesize the researchers.
A new clinical trial aims to apply advanced image analysis techniques to 4D CT scans. Already a standard step in targeting lung cancer radiotherapy, the trial seeks to use the scans map areas of lung function without additional testing.
Researchers identified characteristics that may lead to low patient accrual for a clinical trial.
Excluding patients with renal insufficiency but good performance status from clinical trials due to concern of excessive hematologic toxicity or poor outcomes may not be necessary with appropriate dosing modifications.
Mandatory tumor tissue specimens and associated analyses for clinical trial participation appear to be a significant barrier to clinical trial enrollment and may delay treatment.
A recent study examined the efficacy of pembrolizumab for the treatment of previously treated, PD-L1-positive, advanced non-small-cell lung cancer.
Extra biopsies performed solely to study the pharmacodynamics of a new anticancer drug have no impact on subsequent drug development or on how physicians use these new drugs to treat future patients.
Patient education on clinical trials prior to the first oncologic visit improves knowledge, attitudes, and preparation for decision making about clinical trials.
The number of registered NIH-funded trials listed on ClinicalTrials.gov decreased between 2006 through 2014; however, the number of industry-funded trials increased substantially.
A joint effort from the EORTC, the EANM, the ESR, and the US NCI has resulted in establishing a foundation to improve the implementation and use of imaging biomarkers in cancer clinical trials.
In the first clinical trial of an anti-B-cell maturation antigen chimeric antigen receptor (CAR-BCMA), a strong anti-myeloma response was observed.
A novel immunotherapeutic approach improved outcomes for patients with advanced bladder cancer, according to a recent study.
Biologic Age Need Not be a Limiting Factor for Stem Cell Transplants in Patients with Acute Myeloid Leukemia (AML)November 25, 2015
More than 40% of older patients with AML can remain in long-term cancer remission through a modified, less aggressive approach to donor stem cell transplantation, according to the results of a phase 2 study.
Researchers announced a breakthrough advance in a world-first international clinical trial of a new drug to treat chronic lymphocytic leukemia and non-Hodgkin lymphoma that is refractory or resistant to current chemotherapies.
The search for evidence to support the growing use of proton therapy for more cancers continues to uncover valuable findings. New data from clinical trials demonstrate the potential advantages of proton therapy over conventional radiation for pancreatic cancer, late-stage non-small cell lung cancer, chordoma, and chondrosarcoma.
Scientists have developed a blood test that could help pair cancer patients with the most suitable therapy for their disease, then track disease progression to see if the treatment is effective.
Patients with newly diagnosed cancer were less likely to participate in clinical trials if their annual household income was less than $50,000.
Cancer trial participation decreases with decreasing annual household income, according to recent data.
- Cancer-related Neuropathy May Respond to Gene Therapy
- No Clinical Benefit to Expanding Gene Panel Beyond Ovarian and Breast Cancer Genes in High-risk Women
- A Protein Could Predict the Response to Immunotherapy in Metastatic Melanoma
- Atezolizumab Approved for Locally Advanced or Metastatic Urothelial Carcinoma
- Clinical Results Matches Development Locale With Subtype of Disease in Glioblastoma
- Overall Benefits of Vaporized Nicotine Products Outweigh Harms, Says International Panel of Experts
- Sugar and Cancer: Mitigating the Affects of Diet on Cancer
- Nurse Residency Programs Can Impact Oncology Nursing Practice, Outcomes
- Initiating Palliative Care in the Emergency Department
- Implementing a Distress Screening Process for Cancer Patients
- New Research Questions Recommendations Regarding PSA Tests for Prostate Cancer Screening
- Genetic Biomarker Predictive of Peripheral Neuropathy in Patients Receiving Docetaxel for Prostate Cancer
- Specific Lifestyle Factors Can Significantly Affect Cancer Mortality
- Biomarker Indicates Which Patients With Colorectal Cancer Will Respond to Cetuximab
- Herbal Remedies May Be an Overlooked Global Health Hazard
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