Clinical Trials

Clinical trial success enhanced by biomarker- and receptor-targeted therapies in NSCLC

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Although the cumulative success rate for new agents for advanced NSCLC is lower than the industry-estimated rate, clinical trial success has been substantially increased by biomarker- and receptor-targeted therapies.

Assessing HRQOL is valuable in small-cell lung cancer trials

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Health-related quality of life assessment in randomized clinical trials in small cell lung cancer provides added information in studies where the treatment arms do not differ in terms of efficacy.

Clinical trial data on metformin for cancer are showing conflicting results

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The diabetes drug metformin is undergoing investigation as a potential treatment for different cancers in numerous clinical trials, but results vary.

Endoxifen promising as treatment for ER-positive breast cancer

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A phase 1 trial of endoxifen, an active metabolite of the cancer drug tamoxifen, indicates that the experimental drug is safe and provides early evidence for antitumor activity.

Innovative clinical trial design is a new paradigm in breast cancer research

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The first investigator results from an unprecedented nationwide effort to test promising new breast cancer drugs before the tumor is removed were presented during the 2013 San Antonio Breast Cancer Symposium.

Drug induces morphologic, molecular, and clinical remissions in myelofibrosis

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Imetelstat, a novel telomerase-inhibiting drug, has been found to induce morphologic, molecular, and clinical remissions in some patients with myelofibrosis, according to a new study. The results were presented at the 2013 ASH Annual Meeting, in New Orleans.

Low-intensity therapy for Burkitt lymphoma is highly effective

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Adult patients with Burkitt lymphoma had excellent long-term survival rates—upwards of 90%—following treatment with low-intensity chemotherapy regimens, according to a new clinical trial finding.

NCI and ASCO symposium offer strategies for clinical trial accrual

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A research team from the NCI and ASCO presented a summary of best practices and strategies for future research in a co-sponsored symposium.

Kinase inhibitors target advanced thyroid cancer

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Recent discoveries about the genetics and cell signaling pathways of thyroid tumors have lead to the development of kinase inhibitors that target tumor cell division and blood vessels.

Ramucirumab prolongs survival in advanced gastric cancer

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An investigational drug improved median survival while reducing risk of disease progression or death in persons with metastatic gastric cancer participating in the phase III REGARD trial.

First randomized trial of targeted cancer medicine in all tumor types

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The SHIVA trial is the first randomized trial to look at patient outcomes after treatments were chosen based on individual molecular profiles of each person's tumor.

Clinical Trial: Combined Bone Marrow Transplantation (BMT) and Renal Transplant for Multiple Myeloma (MM) With End Stage Renal Disease (ESRD)

Clinical trial focusing on bone marrow transplantation and rental transplant for multiple myeloma. Combined Bone Marrow Transplantation (BMT) and Renal Transplant for Multiple Myeloma (MM) With End Stage Renal Disease (ESRD)

Clinical Trial: Study of ACY-1215 Alone and in Combination With Bortezomib and Dexamethasone in Multiple Myeloma

Clinical trial focusing on ACY-1215, bortezomib, and dexamethasone. Study of ACY-1215 Alone and in Combination With Bortezomib and Dexamethasone in Multiple Myeloma

Clinical Trial: Prognostic Potential of Cell Surface Markers and Pim Kinases in Multiple Myeloma

Clinical trial focusing on cell surface markers and pim kinases. Prognostic Potential of Cell Surface Markers and Pim Kinases in Multiple Myeloma

Clinical Trial: Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile (CoMMpass)

Clinical trial focusing on genetics and multiple myeloma. Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile (CoMMpass)

Clinical Trial: Open-label Study of TH-302 and Dexamethasone With or Without Bortezomib in Subjects With Relapsed/Refractory Multiple Myeloma

Clinical trial focusing on TH-302, Dexamethasone, and Bortezomib. Open-label Study of TH-302 and Dexamethasone With or Without Bortezomib in Subjects With Relapsed/Refractory Multiple Myeloma

Clinical Trial: Use of the Epidermal Micrografts for Wound Healing After Mohs or Excisional Surgery for Skin Cancer

Clinical trial focusing on epidermal micrografts. Use of the Epidermal Micrografts for Wound Healing After Mohs or Excisional Surgery for Skin Cancer

Clinical Trial: Assessment of Clinically Related Outcomes and Biomarker Analysis for Translational Integration in Colorectal Cancer (ACROBATICC)

Clinical trial focusing on biomarker analysis for translational integration in colorectal cancer. Assessment of Clinically Related Outcomes and Biomarker Analysis for Translational Integration in Colorectal Cancer (ACROBATICC)

Pazopanib tolerated best in kidney cancer study

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A trial comparing pazopanib and sunitinib found pazopanib to have better safety and health-related quality-of-life profiles among persons with metastatic renal cell carcinoma.

Survival in NSCLC predicted by tumor measurements

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Even in advanced stages, total tumor size can have a major impact on survival in non-small cell lung cancer (NSCLC), according to a new study.

Drug reduces prostate cancer risk but has no impact on survival

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After 18 years of follow-up, the drug finasteride was shown to reduce the risk for prostate cancer by approximately one third, but did not significantly affect overall survival in men or survival after prostate cancer diagnosis.

NCI reforms result in faster activation of cancer trials

Changes made 5 years ago to accelerate time-to-initiation of clinical trials sponsored by the National Cancer Institute have paid off in the form of faster activation of studies.

Is phase III testing necessary for targeted cancer drugs with early and obvious benefit?

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FDA-approved clinical trials progress through three phases: the first shows safety, the second determines efficacy and further evaluates safety, and the third seeks to prove a drug's superiority over existing treatments. But when a drug's benefit is obvious in the first or second phase, is the third, and costly, phase needed?

Trial results for cancer drugs often go unpublished

Trial results for cancer drugs often go unpublished

Results for almost half of U.S. cancer drug trials are still not available three years after study completion.

Vaccine stimulates immune response in newly diagnosed advanced melanoma

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A newly reported clinical trial used a vaccine that stimulated dendritic cells to treat newly diagnosed advanced melanoma.

Boosting Hispanic enrollment in clinical trials

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Hispanic cancer patients rarely participate in clinical trials, but researchers want to tailor a Spanish-language DVD to change this situation.

New screening approach quickly identifies small proteins unique to melanoma cells

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A new streamlined method rapidly identifies genetic changes in small protein fragments unique to melanoma cancer cells.

Promise in immune-boosting colorectal cancer drug

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New data has confirmed the biological action of the drug MGN1703 and suggests that it may be possible to identify which patients with gastrointestinal cancer will benefit most from the treatment.

Bevacizumab added to initial glioblastoma treatment does not extend lives

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Adding bevacizumab to initial treatment for glioblastoma did not improve overall patient survival or progression-free survival, according to results of a randomized phase III trial.

New technologies address barriers to clinical trial enrollment

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The use of tailored, web-based videos delivering educational information before an oncologist visit can significantly improve knowledge and reduce attitudinal barriers that impact enrollment in clinical trials, according to one new study.

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