Clinical Trials

More Patients Enrolled in Cancer Trials Under ACA

More Patients Enrolled in Cancer Trials Under ACA

Insurer approval rates rose from 85 percent before Affordable Care Act to 95 percent after the health care bill was enacted.

Rates at Some Milestones May Indicate Clinical Trial Results for Immunotherapeutics

Rates at Some Milestones May Indicate Clinical Trial Results for Immunotherapeutics

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An analysis of rates at certain milestones in clinical trials of treatments for mNSCLC suggests these rates reflect end point results for immunotherapies vs targeted and conventional therapies.

Savolitinib Active, Tolerable in Subset of Advanced Papillary Renal Cell Cancer

Savolitinib Active, Tolerable in Subset of Advanced Papillary Renal Cell Cancer

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Results of a phase 2 clinical trial of savolitinib, a highly selective small molecule inhibitor of c-Met, found the agent was active and tolerable in patients with Met-driven advanced or metastatic papillary renal cell carcinoma (PRCC).

Clinical Trials May Benefit Oncology Patients

Clinical Trials May Benefit Oncology Patients

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Research on the effects of research demonstrated that oncology-related clinical trials provide measurable benefits in terms

Older Patients Under-Represented in Cancer Drug Clinical Trials

Older Patients Under-Represented in Cancer Drug Clinical Trials

Older adults are underrepresented in clinical trials of cancer drugs, according to study findings presented at the 2017 ASCO Annual Meeting.

Older Adults Under-Represented in Cancer Drug Clinical Trials

Older Adults Under-Represented in Cancer Drug Clinical Trials

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Patients aged 80 years and older had a cancer incidence of 16% in 2013 yet made up only 4% of cancer drug clinical trial participants during 2005-2015.

Cognitive Computing Expedites Matching Patients to Clinical Trials

Cognitive Computing Expedites Matching Patients to Clinical Trials

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IBM Watson for Clinical Trial Matching compares study enrollment criteria with patient data in electronic medical records.

IL-11 Plus Glucocorticoids Safe, Effective for ITP in Adults

IL-11 Plus Glucocorticoids Safe, Effective for ITP in Adults

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Recent study results demonstrate that recombinant IL-11 with glucocorticoids is a safe and effective treatment for idiopathic thrombocytopenic purpura (ITP) in adults.

Durable Response Seen in Advanced HCC With Nivolumab

Durable Response Seen in Advanced HCC With Nivolumab

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New data presented at the International Liver Congress 2017 suggest that nivolumab may produce long-term benefits in sorafenib-experienced patients with advanced HCC.

Barriers in Routine Care Coverage for Cancer Clinical Trial Participants Still Exist

Barriers in Routine Care Coverage for Cancer Clinical Trial Participants Still Exist

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Despite the ACA mandate on coverage for clinical trial participants, many facilities involved in cancer research still coping with insurance denials for participants.

CTCs Promising as Biomarker to Identify Lung Cancer Recurrence

CTCs Promising as Biomarker to Identify Lung Cancer Recurrence

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Prospective pilot study demonstrates accuracy of circulating tumor cells as a biomarker indicating lung cancer recurrence.

Characteristics of Clinical Trials and Barriers to Patient Enrollment Identified

Characteristics of Clinical Trials and Barriers to Patient Enrollment Identified

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Study identifies characteristics of clinical trials and barriers to patient accrual.

Women May Significantly Benefit from Entering OB/GYN Clinical Trials

Women May Significantly Benefit from Entering OB/GYN Clinical Trials

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The researchers hope the results will lead to an increase in clinicians offering trials to their patients and an increase in women volunteering to participate in trials.

VBPWPs Can Compliment Patient Management in Clinical Trials

VBPWPs Can Compliment Patient Management in Clinical Trials

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Video Based Personal Webpages (VBPWP) Can Be Used as a Compliment to Clinical Trial Patient Management

Clinical Trial Enrollment of Adolescent and Young Adult Patients With Cancer: A Systematic Review of the Literature and Proposed Solutions

Clinical Trial Enrollment of Adolescent and Young Adult Patients With Cancer: A Systematic Review of the Literature and Proposed Solutions

[Clinical Oncology in Adolescents and Young Adults] This research evaluates methods that have been utilized in the clinical trial enrollment for adolescent and young adults with cancer.

Video Tool to Increase Breast Cancer Clinical Trial Participation Among Black Women

Video Tool to Increase Breast Cancer Clinical Trial Participation Among Black Women

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A new tool may show promise for improving clinical trial participation among black women with breast cancer, according to a study presented at the 2016 San Antonio Breast Cancer Symposium (SABCS).

Combination of Gemcitabine and New CHK1 Inhibitor Is Effective in Soft Tissue Sarcomas

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In a phase 1 clinical trial, the combination produces a significant and long-lasting response in patients with advanced disease including metastases to the peritoneum and lung.

Panobinostat, Bortezomib, Thalidomide Efficacious in Relapsed Myeloma

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In this study, researchers sought to improve the safety of panobinostat plus bortezomib and dexamethasone for relapsed or relapsed and refractory multiple myeloma.

CDK4/6 Inhibitor Plus Aromatase Inhibitor Improves Progression-Free Survival in Metastatic Breast Cancer

CDK4/6 Inhibitor Plus Aromatase Inhibitor Improves Progression-Free Survival in Metastatic Breast Cancer

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Adding ribociclib to letrozole significantly improves progression-free survival for postmenopausal women with metastatic hormone receptor (HR)-positive breast cancer, compared with hormone therapy alone.

Cancer Patients Have Unrealistic Hopes When Entering Clinical Trials

Cancer Patients Have Unrealistic Hopes When Entering Clinical Trials

Questionnaires completed by patients with cancer considering enrollment in early-stage clinical trials indicate they may have unrealistic expectations.

Affordable Care Act Tied to Increased Breast Cancer Care Access for Hispanics

Affordable Care Act Tied to Increased Breast Cancer Care Access for Hispanics

Following the release of the Affordable Care Act (ACA) an increase in Hispanic women receiving breast cancer treatment and their related participation in clinical trials was observed.

How Can We Have a Cancer Cure Moonshot if We're Short of Fuel?

How Can We Have a Cancer Cure Moonshot if We're Short of Fuel?

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Cancer research relies of patients with cancer to participate in clinical trials. However, many patients cite various fears and misconceptions — some supported by physicians - as reasons for why they decline to participate in clinical trials.

Increasing Numbers of Older Cancer Survivors Challenge Clinical Trial Participant Criteria

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Improved cancer detection and advances in treatment mean larger numbers of older cancer patients are becoming survivors, combined with demographic trends. But older patients are underrepresented in clinical trials.

Poor Sleep Quality Negatively Impacts Some Adverse Effects in Patients With Advanced Cancer

Poor Sleep Quality Negatively Impacts Some Adverse Effects in Patients With Advanced Cancer

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Patients participating in early-phase clinical trials should be assessed for sleep quality, as poor sleep quality is associated with greater fatigue, symptom burden, and mood disturbance.

Analysis Shows Better Integration Needed Between ClinicalTrials.gov and Drugs@FDA

Analysis Shows Better Integration Needed Between ClinicalTrials.gov and Drugs@FDA

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Although Drugs@FDA may be useful for validating trial primary outcomes found on ClinicalTrials.gov, Drugs@FDA lacked information on secondary outcomes and adverse events, including deaths, according to an analysis of data from 100 trials available on both websites.

Novel Antibody-Drug Conjugate Bridges Patients With Relapsed ALL to Stem Cell Transplant

Novel Antibody-Drug Conjugate Bridges Patients With Relapsed ALL to Stem Cell Transplant

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In a randomized phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with ALL whose disease had relapsed following standard therapies, qualified for stem cell transplants after treatment with the drug.

DECT Trial Results Show Trastuzumab Plus Anthracyclines Are Efficacious in HER2+ Breast Cancer

DECT Trial Results Show Trastuzumab Plus Anthracyclines Are Efficacious in HER2+ Breast Cancer

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Results from the DECT trial indicate that a combination of epirubicin and trastuzumab improved outcomes in patients with HER2-positive breast cancer.

Outcomes in Clinical Trials Using Precision Medicine Demonstrate Effectiveness of Modality in Patients With Cancer

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A meta-analysis of hundreds of cancer clinical trials revealed that therapeutic approaches using precision medicine had improved responses and longer disease remission, even in phase I trials.

Surrogate End Points Are Poor Predictors of Survival in Cancer Drug Approval

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US FDA standards demand that surrogate end points used in clinical trials be "reasonably likely to predict" survival for accelerated approval, or be established proxies for survival for traditional approval; however, surrogate end points used frequently lack formal study.

Daratumumab in Combination With Standard-of-Care Treatment Significantly Improves Outcomes in Patients With Multiple Myeloma

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Daratumumab in combination with the standard-of-care treatment regimen reduced risk of disease progression or death by 63% compared with the standard-of-care regimen alone in patients with multiple myeloma who had received at least 1 prior line of therapy.

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