Clinical Trials

Bevacizumab added to initial glioblastoma treatment does not extend lives

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Adding bevacizumab to initial treatment for glioblastoma did not improve overall patient survival or progression-free survival, according to results of a randomized phase III trial.

New technologies address barriers to clinical trial enrollment

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The use of tailored, web-based videos delivering educational information before an oncologist visit can significantly improve knowledge and reduce attitudinal barriers that impact enrollment in clinical trials, according to one new study.

First prospective trial finds molecular profiling timely for advanced cancers

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A clinical trial has shown that patients and their physicians are eager to jump into next-era cancer care, which is analysis of a patient's tumor to find and target genetic mutations that drive the cancer. The results of the study, CUSTOM, are being presented at the 2013 annual meeting of the American Society of Clinical Oncology.

Late recurrence in estrogen-positive breast cancer predicted by genetic and clinical factors

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Among women with estrogen-receptor positive breast cancer, late recurrence was best predicted by the clinical treatment score. Significant prognostic value was added by the PAM50 risk of recurrence score and by the Breast Cancer Index score, according to a study comparing five scores that was presented at the 5th IMPAKT Breast Cancer Conference in Brussels, Belgium.

Basal-cell carcinoma targeted by new deoxyribozyme drug

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A new class of drugs targeting the genetic material of skin cancer has been successfully tested in humans for the first time. This opens the way to new treatments for a range of conditions from skin cancers to eye diseases.

Treating hepatocellular carcinoma with transarterial chemoembolization and selective internal radiotherapy

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New light was shed on the use of TACE and SIRT in the treatment of hepatocellular carcinoma (HCC) by data from clinical trials presented at the International Liver Congress 2013 in Amsterdam, the Netherlands.

Rigosertib well tolerated in patients with advanced solid tumors

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Orally administered rigosertib was found to be well-tolerated in patients with advanced solid tumors in a phase 1 trial. Rigosertib is a dual kinase inhibitor, and this trial is the first to study its orally administered form in solid tumors.

New class of cancer drugs safe and effective in clinical trial

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A new class of tumor-fighting drugs that use RNA interference were studied for their safety and preliminary efficacy.

Publication of clinical trials often delayed by several years

Publication of clinical trials often delayed by several years

Funding source, number of participants, and journal impact factor all affect time to publication.

Greater representation of elderly patients in phase III trials is needed

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The median age of patients diagnosed with advanced NSCLC has steadily increased over recent years and is presently 70 years. Despite this, the elderly are significantly underrepresented in clinical trials.

Study drug is first to help patients with recurrent low-grade ovarian cancer

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A phase II clinical trial provides the first evidence of a relatively high response rate in patients with low-grade serous ovarian cancer receiving the drug selumetinib.

Bevacizumab prolongs life in ongoing trial of cervical cancer

Bevacizumab plus chemotherapy improved survival in women with advanced, recurrent, or persistent cervical cancer, according to interim findings.

New drug protects against chemotherapy side effects

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A new drug, calmangafodipir, protects against the side effects of cancer treatments while strengthening the effects on the tumor. An international drug evaluation is now beginning with a larger group of patients.

Drug combination extends survival of patients with pancreatic cancer

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A multicenter phase III clinical trial has demonstrated that nab-paclitaxel (Abraxane) plus gemcitabine extends the survival of late-stage pancreatic cancer patients compared with standard treatment.

A bias toward positive end points is seen in published studies of breast cancer trials

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A third of all trials that failed to show a statistically significant benefit for the treatment under investigation focused on other, less important outcomes in order to put a positive spin on the results, according to a recent study.

Novel drug targets aggressive form of non-Hodgkin lymphoma

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A new experimental drug therapy has been developed to target activated B-cell diffuse large B-cell lymphoma.

Ibrutinib may be a breakthrough for treatment of a rare lymphoma

Interim results confirmed the "unprecedented" single-agent activity of ibrutinib in relapsed or refractory mantle cell lymphoma.

Best leukemia therapy may depend on patient age

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Older patients may not respond as well as younger persons to conventional therapies for chronic lymphocytic leukemia, a new study indicates.

Pomalidomide extends survival in multiple myeloma

A new immunomodulatory drug under FDA review significantly increased survival in persons with multiple myeloma, including older patients.

Zytiga approved for metastatic prostate cancer

The FDA has expanded the indication for abiraterone acetate (Zytiga tablets) to combat metastatic castration-resistant prostate cancer.

Study drug makes marrow transplant possible in relapsed leukemia

The final data from a phase II study confirmed the high degree of activity of quizartinib in persons with acute myeloid leukemia.

DNA vaccine for leukemia has early positive results

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Early results of a trial to treat leukemia with WT1 DNA vaccine have shown robust vaccine-specific antibody responses in all vaccinated patients evaluated to date.

Bone metastasis from prostate cancer responds to new drug

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About two-thirds of patients treated with cabozantinib had improvements on their bone scans, with 12% seeing complete resolution on uptake on bone scans.

Ibrutinib appears safe, effective against chronic lymphocytic leukemia

Ibrutinib, which targets the Bruton's tyrosine kinase to combat chronic lymphocytic leukemia, showed promising results in two phase II studies.

Eribulin may be useful earlier in breast cancer

A drug used for metastatic breast cancer after several previous treatments may improve survival when administered earlier in the disease course.

Anticancer agent reduces complications after stem-cell transplant

Vorinostat, already used in lymphoma, reduces the risk of graft-versus-host disease after allogeneic hematopoietic stem-cell transplantation.

Some breast cancers may respond to anti-androgen drug

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Newly approved for prostate cancer, enzalutamide may be useful as a therapeutic agent in breast cancer that evades other treatments.

Annual report highlights 2012 cancer advances

The American Society of Clinical Oncology has released a nearly 100-page report detailing the year's most significant developments in cancer.

Metformin shows benefit in ovarian cancer

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Use of the oral antidiabetes drug metformin improved survival in women with ovarian cancer, according to the findings of a retrospective case-control study.

Regorafenib prolongs survival in face of GI cancers

Persons with metastatic colorectal cancer or gastrointestinal stromal tumors may garner some survival benefit from regorafenib after standard treatments have failed.

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