Clinical Trials

Chemoradiotherapy Showed No Survival Benefit Over Chemotherapy in Locally Advanced Pancreatic Cancer

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Researchers discovered no survival benefit of chemoradiotherapy over chemotherapy in treating locally advanced pancreatic cancer in the LAP01 Randomized Clinical Trial.

Experimental Targeted Therapy Succeeds in Rare Pediatric Cancer

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The experimental treatment LOXO-101 led to remarkable improvement for a 20-month-old girl whose rare pediatric cancer did not respond to surgery or chemotherapy.

Tumor Regression Achieved With LOXO-101 in Phase 1 Study

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Tumors of varied types of genetically defined cancer were significantly reduced by the drug LOXO-101, according to phase 1 study results.

Research Unit Aims To Train Nurses to Provide Better Care to Clinical Trial Patients

Research Unit Aims To Train Nurses to Provide Better Care to Clinical Trial Patients

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A research unit created by oncology nurses trains nurses to provide high quality care to patients in oncology clinical trials.

Clinical Trial Infusion Nurse Orientation Improves Care for Patients in Investigational Studies

Clinical Trial Infusion Nurse Orientation Improves Care for Patients in Investigational Studies

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A clinical trial infusion nurse orientation improves training for nurses so they can better care for patients participating in investigational trials.

Antibody Therapy Reduces Numbers of Cancer Stem Cells in Patients With Multiple Myeloma

Antibody Therapy Reduces Numbers of Cancer Stem Cells in Patients With Multiple Myeloma

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Cancer stem cells that drive tumor growth were halved by MEDI-551, an experimental antibody treatment for multiple myeloma, according to results of a small preliminary clinical trial.

Shortened Radiation Therapy Schedule No Worse Than Conventional Radiotherapy in Low-Risk Prostate Cancer

Shortened Radiation Therapy Schedule No Worse Than Conventional Radiotherapy in Low-Risk Prostate Cancer

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Treatment with a hypofractionated radiotherapy (HRT) schedule achieved similar efficacy as treatment with the longer, conventional RT (CRT) schedule in men with low-risk prostate cancer.

Radiotherapy/Histone Deacetylase Inhibitor Combination Safe, Effective in High-grade Gliomas

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Adding panobinostat to radiotherapy appears safe, tolerable, and has preliminary efficacy for treating recurrent high-grade gliomas.

Social Media Has Unrealized Potential for Clinical Trial Communication and Recruitment

Social Media Has Unrealized Potential for Clinical Trial Communication and Recruitment

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The social media platform Twitter could develop into a useful tool for communicating with the public about cancer clinical trials and for recruiting participants.

Combination of Immune Checkpoint Blockers Shows Promise in Lung Cancer

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Combination therapy with durvalumab and tremelimumab demonstrated antitumor activity in 23% of 102 patients with lung cancer in a phase 1b trial, and toxicity was manageable.

Interferon Has Little Benefit for Patients With Small Amounts of Melanoma in the Lymph Nodes

Interferon Has Little Benefit for Patients With Small Amounts of Melanoma in the Lymph Nodes

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No evidence that interferon is necessary or helpful in cases of melanoma with minimal metastasis to the lymph nodes, according to the final results of the Sunbelt Melanoma Trial.

Targeted Hormone-radiation Treatment Shows Promise in Midgut Neuroendocrine Tumors

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Tumor growth may be substantially slowed by the novel therapy 177Lutetium-DOTATATE (Lutathera), according to early results from a phase III study of patients with previously treated, advanced midgut neuroendocrine tumors.

Optical Probes That Illuminate Solid Tumors in Surgery Move One Step Closer to Reality

Optical Probes That Illuminate Solid Tumors in Surgery Move One Step Closer to Reality

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Optical probes that make cancer cells glow and improve surgical tumor removal are in phase I and II clinical trials in humans. The probes could be commonplace in the next 5 to 10 years, hypothesize the researchers.

Mapping Tumor Position During Lung Function Improves Radiation Therapy for Lung Cancer

Mapping Tumor Position During Lung Function Improves Radiation Therapy for Lung Cancer

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A new clinical trial aims to apply advanced image analysis techniques to 4D CT scans. Already a standard step in targeting lung cancer radiotherapy, the trial seeks to use the scans map areas of lung function without additional testing.

Certain Characteristics of Clinical Trials May Predict Poor Accrual of Participants

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Researchers identified characteristics that may lead to low patient accrual for a clinical trial.

No Need to Exclude Patients With Renal Insufficiency From Clinical Trials

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Excluding patients with renal insufficiency but good performance status from clinical trials due to concern of excessive hematologic toxicity or poor outcomes may not be necessary with appropriate dosing modifications.

Mandatory Biopsy May Hinder Eligibility of Potential Participants in Cancer-related Clinical Trials

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Mandatory tumor tissue specimens and associated analyses for clinical trial participation appear to be a significant barrier to clinical trial enrollment and may delay treatment.

Pembrolizumab Increases Overall Survival for PD-L1-positive, Advanced Non-small Cell Lung Cancer

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A recent study examined the efficacy of pembrolizumab for the treatment of previously treated, PD-L1-positive, advanced non-small-cell lung cancer.

Extra Biopsies in Clinical Trials Often Have No Impact on Drug Dose or Use in Cancer Treatments

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Extra biopsies performed solely to study the pharmacodynamics of a new anticancer drug have no impact on subsequent drug development or on how physicians use these new drugs to treat future patients.

Patient Education Prior to Oncologist Visit Improves Knowledge and Attitude Toward Clinical Trials

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Patient education on clinical trials prior to the first oncologic visit improves knowledge, attitudes, and preparation for decision making about clinical trials.

ClinicalTrials.gov Shows NIH Funding On the Decline, Industry Funding On the Upswing

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The number of registered NIH-funded trials listed on ClinicalTrials.gov decreased between 2006 through 2014; however, the number of industry-funded trials increased substantially.

International Effort Produces Risk Management Plan for Functional Imaging in Cancer Clinical Trials

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A joint effort from the EORTC, the EANM, the ESR, and the US NCI has resulted in establishing a foundation to improve the implementation and use of imaging biomarkers in cancer clinical trials.

CAR T cells Can Have Powerful Activity in Multiple Myeloma

CAR T cells Can Have Powerful Activity in Multiple Myeloma

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In the first clinical trial of an anti-B-cell maturation antigen chimeric antigen receptor (CAR-BCMA), a strong anti-myeloma response was observed.

Investigational Immunotherapeutic Approach Increased Survival in Patients With Bladder Cancer

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A novel immunotherapeutic approach improved outcomes for patients with advanced bladder cancer, according to a recent study.

Biologic Age Need Not be a Limiting Factor for Stem Cell Transplants in Patients with Acute Myeloid Leukemia (AML)

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More than 40% of older patients with AML can remain in long-term cancer remission through a modified, less aggressive approach to donor stem cell transplantation, according to the results of a phase 2 study.

Breakthrough Advance Announced in International Blood Cancer Drug Trial

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Researchers announced a breakthrough advance in a world-first international clinical trial of a new drug to treat chronic lymphocytic leukemia and non-Hodgkin lymphoma that is refractory or resistant to current chemotherapies.

Studies Demonstrate Clinical Advantages of Proton Therapy

Studies Demonstrate Clinical Advantages of Proton Therapy

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The search for evidence to support the growing use of proton therapy for more cancers continues to uncover valuable findings. New data from clinical trials demonstrate the potential advantages of proton therapy over conventional radiation for pancreatic cancer, late-stage non-small cell lung cancer, chordoma, and chondrosarcoma.

Blood Test Could Match Cancer Patients to Best Treatments

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Scientists have developed a blood test that could help pair cancer patients with the most suitable therapy for their disease, then track disease progression to see if the treatment is effective.

Patients With Lower Income Less Likely to Participate in Clinical Trials

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Patients with newly diagnosed cancer were less likely to participate in clinical trials if their annual household income was less than $50,000.

Lower-Income Cancer Patients Show Decreased Trial Participation

Lower-Income Cancer Patients Show Decreased Trial Participation

Cancer trial participation decreases with decreasing annual household income, according to recent data.

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