Psoriasis Treatments

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PSORIASIS TREATMENTS
PSORIASIS TREATMENTS

These medications are not recommended for children
and should be used for adults that are ≥18yrs old.

Generic Brand Adult Dosage
INTERLEUKIN-12 AND INTERLEUKIN-23 ANTAGONIST1
ustekinumab Stelara 12–17yrs: give SC at Weeks 0 and 4, then every 12wks thereafter. (<60kg): 0.75mg/kg; (60–100kg): 45mg; (>100kg): 90mg. ≥18yrs (≤100kg): initially 45mg SC once, then 4wks later, and then once every 12wks; (>100kg): initially 90mg once, then 4wks later, and then once every 12wks.
INTERLEUKIN-17A ANTAGONIST
brodalumab Siliq 210mg SC at Weeks 0, 1, and 2, then 210mg every 2wks.
ixekizumab Taltz 160mg (given as two 80mg SC injections) at Week 0, then 80mg at Weeks 2, 4, 6, 8, 10, and 12, then 80mg every 4wks.
secukinumab Cosentyx 300mg (given as two 150mg SC injections) at Weeks 0, 1, 2, 3, and 4 then 300mg every 4wks. For some patients, 150mg dose may be acceptable.
INTERLEUKIN-23 ANTAGONIST
guselkumab Tremfya 100mg SC at Weeks 0 and 4, then give every 8wks.
PSORALEN2
methoxsalen 8-MOP Take Oxsoralen-Ultra 1½–2hrs or 8-MOP 2hrs before UVA exposure with low fat food or milk. (<30kg): 10mg; (30–50kg): 20mg; (51–65kg): 30mg; (66–80kg): 40mg; (81–90kg): 50mg; (91–115kg): 60mg; (>115kg): 70mg.
Oxsoralen-Ultra
TUMOR NECROSIS FACTOR (TNF) BLOCKERS1
adalimumab Humira Initially 80mg SC, followed by 40mg every other week 1wk after initial dose.
etanercept Enbrel Initially 50mg SC twice weekly for 3mos (also: initial doses of 25mg or 50mg per week were shown to be efficacious). Maintenance: 50mg once weekly.
infliximab Remicade 5mg/kg IV infusion at Weeks 0, 2 and 6; then give every 8wks.
OTHERS
acitretin Soriatane 25–50mg once daily with main meal; may discontinue when lesions resolve. May repeat if relapse occurs.
apremilast Otezla Starting on Day 1: 10mg in the AM. Day 2: 10mg in AM and 10mg in PM. Day 3: 10mg in AM and 20mg in PM. Day 4: 20mg in AM and 20mg in PM. Day 5: 20mg in AM and 30mg in PM. Following on Day 6 and thereafter: 30mg twice daily (AM & PM).
betamethasone dipropionate Sernivo Apply twice daily for up to max 4wks; discontinue when control is achieved.
calcipotriene + betamethasone dipropionate Enstilar Apply once daily for up to 4wks; discontinue when control is achieved; max 60g every 4 days.
cyclosporine Gengraf3 1.25mg/kg twice daily; may increase after 4wks by 0.5mg/kg/day, then adjust at 2-week intervals; max 4mg/kg/day.
Neoral3 1.25mg/kg twice daily; may increase after 4wks by 0.5mg/kg/day, then adjust at 2-week intervals; max 4mg/kg/day.
methotrexate Otrexup 10-25mg once weekly using an oral, IM, SC, or IV form; max 30mg/wk. Use alternative MTX form in patients requiring oral, IM, IV, intra-arterial, or intrathecal dosing, doses <7.5mg/week or >30mg/week, high-dose regimens, or dose adjustments <2.5mg increments.
Rasuvo
NOTES

1 These medications should only be used under the guidance and supervision of a physician.

2 Intended to be administered only in conjunction with a schedule of controlled doses of long wave UV radiation. See full labeling for UVA exposure schedule.

3 Not bioequivalent to all other forms of cyclosporine; do not interchange without physician supervision.

Not an inclusive list of medications and/or official indications. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Rev. 11/2017)

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