Migraine and Headache Treatments

MIGRAINE AND HEADACHE TREATMENTS
Generic Strength Brand Form Dose
ANALGESIC + BARBITURATE
acetamin-
ophen
325mg Rx caps, tabs Adults: 1–2 tabs or caps every 4hrs as needed; max 6/day
Children: Not established.
butalbital 50mg
caffeine 40mg
acetamin-
ophen
300mg Fioricet Rx caps Adults: 1–2 caps every 4hrs; max 6/day
Children: Not recommended.
butalbital 50mg
caffeine 40mg
acetamin-
ophen
325mg Rx tabs Adults: 1–2 tabs every 4hrs; max 6/day.
Children: Not recommended.
butalbital 50mg
ANALGESIC + BARBITURATE + OPIOID
acetamin-
ophen
300mg Fioricet
w. 
Codeine
CIII caps Adults: 1–2 caps every 4hrs; max 6/day.
Children: Not recommended.
butalbital 50mg
caffeine 40mg
codeine
phosphate
30mg
ANALGESIC + SALICYLATE
acetamin-
ophen
250mg Bayer Migraine Formula OTC caplets Adults: 2 caplets with a glass of water; max 2 caplets/24hrs.
Children: Not recommended.
aspirin 250mg
caffeine 65mg
acetamin-
ophen
250mg Excedrin Migraine OTC caplets Adults: 2 caplets with a glass of water; max 2/day.
Children: Consult physician.
aspirin 250mg
caffeine 65mg
BARBITURATE + SALICYLATE
aspirin 325mg Fiorinal CIII tabs, caps Adults: 1–2 tabs or caps every 4hrs as needed; max 6/day.
Children: Not recommended.
butalbital 50mg
caffeine 40mg
BARBITURATE + SALICYLATE + OPIOID
aspirin 325mg Fiorinal
w. 
Codeine
CIII caps Adults: 1–2 tabs or caps every 4hrs as needed; max 6/day.
Children: Not recommended.
butalbital 50mg
caffeine 40mg
codeine
phosphate
30mg
ERGOT ALKALOID
dihydro-
ergotamine
mesylate
1mg/mL D.H.E. 45 Rx IM, IV, or SC inj Adults: 1mL IV at 1hr intervals; max 2 doses/day. Or, 1mL IM or SC at 1hr intervals; max 3 doses/day. For all: max 6 doses/wk. Not for chronic use.
Children: Not recommended.
4mg/mL Migranal Rx nasal spray Adults: 1 spray in each nostril, repeat 15mins later; max 6 sprays/24hrs and 8 sprays/wk.
Children: Not recommended.
ergotamine 
tartrate
1mg Rx tabs Adults: 2 tabs at onset of attack, then 1 tab every ½hr if needed; max 6 tabs/attack, 10 tabs/wk.
Children: Not recommended.
caffeine 100mg
ergotamine 
tartrate
2mg Rx rectal supp Adults: 1 supp rectally at onset of attack, then 1 supp after 1hr if needed; max 2 supps/attack, 5 supps/wk.
Children: Not recommended.
caffeine 100mg
NON-STEROIDAL ANTI‑INFLAMMATORY (NSAID)
diclofenac
potassium
50mg Cambia Rx buffered pwd for oral soln* Adults: Mix 1 packet (50mg) with 30–60mL of water only and drink immediately. Not bioequivalent to other forms of diclofenac.
Children: Not recommended.
ibuprofen 200mg Advil Migraine OTC liq-filled caps Adults: Usually 400mg once daily.
Children: Not recommended.
200mg Motrin Migraine Pain OTC caplets Adults: Usually 200–400mg once daily.
Children: Not recommended.
SELECTIVE 5-HT1B/1D RECEPTOR AGONIST
almotriptan
(malate)
6.25mg, 12.5mg Axert Rx tabs Adults: 6.25–12.5mg single dose; may repeat once after 2hrs; max 25mg/24hrs. Hepatic impairment, CrCl 10–30mL/min, or concomitant potent CYP3A4 inhibitors: initially 6.25mg once; max 12.5mg/24hrs. The safety of treating an average of more than 4 migraines over 30 days is not established.
Children: Not established.
eletriptan HBr 20mg, 40mg Relpax Rx tabs Adults: 20mg or 40mg once. May repeat once after 2hrs; max 80mg/day. The safety of treating an average of more than 3 headaches in a 30-day period has not been established.
Children: Not established.
frovatriptan
(as succinate)
2.5mg Frova Rx tabs Adults: 2.5mg with fluids; may repeat once after 2hrs; max 7.5mg/24hrs. The safety of treating an average of more than 4 headaches in a 30-day period has not been established.
Children: Not recommended.
naratriptan HCl 1mg, 2.5mg Amerge Rx tabs Adults: 1mg or 2.5mg with fluids; may repeat once after 4hrs; max 5mg/24hrs. The safety of treating, on average, more than 4 headaches in a 30-day period has not been established. Mild-to-moderate renal/hepatic impairment: initially 1mg; max 2.5mg/24hrs.
Children: Not recommended.
rizatriptan
(as benzoate)
5mg, 10mg Maxalt Rx tabs Adults: Initially 5 or 10mg; may repeat after 2hrs; max 30mg/day. Concomitant propranolol: 5mg; max 3 doses/day. The safety of treating, on average, more than 4 headaches in a 30-day period has not been established.
Children: Not recommended.
5mg, 10mg Maxalt-MLT Rx ODT*
sumatriptan
(as succinate)
6mg/
 
0.5mL
Alsuma Rx soln for SC inj Adults: One (6mg) dose SC to the lateral thigh or upper arm only. May repeat after 1hr; max two (6mg) doses in 24hrs.
Children: Not recommended.
4mg/
 
0.5mL, 6mg/
 
0.5mL
Imitrex Injection Rx SC inj Adults: 6mg SC (may start at lower dose if 6mg not tolerated). May repeat after 1hr; max two 6mg doses in 24hrs.
Children: Not recommended.
5mg/
 
spray, 20mg/
 
spray
Imitrex Nasal Spray Rx nasal spray Adults: 5mg, 10mg, or 20mg once. May repeat once after 2hrs; max 40mg/day. The safety of treating an average of more than 4 headaches in a 30-day period has not been established.
Children: Not recommended.
25mg, 50mg, 100mg Imitrex Tablets Rx tabs Adults: 25–100mg once, swallow whole with fluids as soon as possible after migraine onset; may repeat dose at intervals of at least 2hrs, max 200mg/day; or single-dose tablets up to 100mg/day if injection has been used. The safety of treating an average of more than 4 headaches in a 30-day period has not been established.
Children: Not recommended.
11mg Onzetra Xsail Rx caps for nasal inh Adults: 1 nosepiece (11mg) in each nostril (22mg total), using Xsail delivery device. May repeat once after ≥2hrs; max 44mg (4 nosepieces)/day or one dose of Onzetra Xsail and one dose of another sumatriptan product separated by ≥2hrs. The safety of treating an average of more than 4 headaches in a 30-day period has not been established.
Children: Not established.
4mg/
 
0.5mL, 6mg/
 
0.5mL
Sumavel Dosepro Rx soln for SC inj Adults: Cluster headache: one (6mg) DosePro SC to the abdomen or thigh only. Migraine: may use one (4mg) or (6mg) DosePro SC to the abdomen or thigh only. May repeat after 1hr; max 12mg in 24hrs.
Children: Not recommended.
6.5mg/
 
4hrs
Zecuity Rx trans-
dermal system
Adults: 1 transdermal system applied to the upper arm or thigh only. Max 2 systems in 24hrs; 2nd system should be applied to a different site no sooner than 2hrs after activation of the 1st system.
Children: Not recommended.
3mg/0.5mL Zembrace Symtouch Rx soln for SC inj Adults: 3mg SC. May repeat after ≥1hr; max 12mg in 24hrs.
Children: Not recommended.
zolmitriptan 2.5mg+, 5mg Zomig Rx tabs Adults: Initially 1.25–2.5mg; max recommended single dose: 5mg. If headache returns, may repeat after 2hrs; max 10mg/day. The safety of treating an average of more than 3 headaches in a 30-day period has not been established. Concomitant cimetidine: max single dose: 2.5mg, not to exceed 5mg in 24-hr period.
Children: Not recommended.
5mg/
 
spray
Zomig Nasal Spray Rx nasal spray Adults: 5mg once. If headache returns, may repeat once after 2hrs; max 10mg/day. The safety of treating an average of more than 4 headaches in a 30-day period has not been established.
Children: Not recommended.
2.5mg, 5mg Zomig-ZMT Rx ODT* Adults: Initially 1.25–2.5mg; max recommended single dose: 5mg. If headache returns, may repeat after 2hrs; max 10mg/day. The safety of treating an average of more than 3 headaches in a 30-day period has not been established. Concomitant cimetidine: max single dose: 2.5mg, not to exceed 5mg in 24-hr period.
Children: Not recommended.
SELECTIVE 5-HT1B/1D RECEPTOR AGONIST + NON‑STEROIDAL ANTI‑INFLAMMATORY (NSAID)
sumatriptan succinate/
naproxen sodium
10/
 
60mg,
85/
 
500mg
Treximet Rx tabs Adults: 1 tab (85/500mg) once; may repeat once after 2 hrs; max 2 tabs/day. The safety of treating an average of more than 5 migraines in a 30-day period has not been established.
Children: <12yrs: not recommended.
12–17yrs: 1 tab (10/60mg) once; max 1 tab (85/500mg)/day. The safety of treating an average of more than 2 migraines in a 30-day period has not been established.
NOTES

Key: ODT = orally disintegrating tablets; soln = solution; supp = suppositories; + = scored tablets

*contains phenylalanine;  contains caffeine

Not an inclusive list of medications, official indications and/or dosages. Please see drug monograph at www.eMPR.com, contact company for full drug labeling and/or consult your healthcare provider.

(Rev. 8/2016)

Loading links....
You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs