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Chlorzoxazone
Musculoskeletal pain
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Drug Name:

Chlorzoxazone Rx

Generic Name and Formulations:
Chlorzoxazone 375mg, 750mg+; tabs; +scored.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Chlorzoxazone:

As adjunct to rest, physical therapy, and other measures in acute, painful musculoskeletal conditions.

Adult:

375mg: 1 tab 3–4 times daily; may increase to 2 tabs (750mg) 3–4 times daily if inadequate response. 750mg: ⅓ tab (250mg) 3–4 times daily. Painful musculoskeletal conditions: initially ⅔ tab (500mg) 3–4 times daily; may increase to 1 tab (750mg) 3–4 times daily if inadequate response. May reduce dose based on improvement.

Children:

Not recommended.

Contraindications:

Known drug intolerance.

Warnings/Precautions:

Monitor for hepatotoxicity; discontinue if hepatic dysfunction or abnormal liver enzymes develop. Known allergies or history of. Discontinue if sensitivity reaction occurs. Pregnancy.

Interactions:

Additive effects with concomitant alcohol, other CNS depressants.

Pharmacological Class:

Muscle relaxant (central).

Adverse Reactions:

Drowsiness, dizziness, lightheadedness, malaise, overstimulation; rare: skin rash, petechiae, ecchymosis, fatal hepatocellular toxicity.

Note:

Formerly known under the brand name Lorzone.

How Supplied:

Contact supplier.

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