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Chlorpromazine injection
Nausea
Psychosis
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Drug Name:

Chlorpromazine injection Rx

Generic Name and Formulations:
Chlorpromazine HCl 25mg/mL; for IV inj after dilution or IM inj; contains sulfites; multidose vials contain benzyl alcohol.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Chlorpromazine injection:

Nausea and vomiting.

Adult:

25–50mg IM every 3–4hrs if needed.

Children:

<6months: not recommended. ≥6months: 0.25mg/lb IM every 6–8hrs if needed. <5yrs or <50lbs: max 40mg/day; ≥5yrs or 50–100lbs: usual max 75mg/day.

Contraindications:

Coma. CNS or bone marrow depression. Reye's syndrome.

Warnings/Precautions:

Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular, respiratory, renal, or liver disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat or organophosphates. Asthma (inj). Monitor blood, liver, and ocular function. Elderly. Pregnancy, nursing mothers: not recommended.

Interactions:

Potentiates phenytoin, alcohol, other CNS depressants, propranolol. Potentiated by propranolol. Antagonized by anticholinergics. Atropine. Decreased guanethidine, anticoagulant effects.

See Also:

Chlorpromazine

Pharmacological Class:

Phenothiazine.

Adverse Reactions:

Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, extrapyramidal reactions, neuroleptic malignant syndrome.

Note:

Formerly known under the brand name Thorazine.

How Supplied:

Contact supplier.

Indications for Chlorpromazine injection:

Rapid control of severe psychotic symptoms. Severe childhood behavior disorders. Adjunct in tetanus.

Adult:

Psychosis: 25mg IM; may repeat in 1 hour, then switch to oral forms. Tetanus: 25–50mg IM 3–4 times daily or 25–50mg IV (see literature).

Children:

<6months: not recommended. ≥6months: Severe behavior disorders: 0.25mg/lb IM every 6–8 hrs if needed. Tetanus: 0.25mg/lb IM or IV (see literature) every 6–8 hrs. Both: <5yrs or <50lbs: max 40mg/day; ≥5yrs or 50–100lbs: usual max 75mg/day.

Contraindications:

Coma. CNS or bone marrow depression. Reye's syndrome.

Warnings/Precautions:

Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular, respiratory, renal, or liver disease. Epilepsy. Glaucoma. History of breast cancer. Exposure to extreme heat or organophosphates. Asthma (inj). Monitor blood, liver, and ocular function. Elderly. Pregnancy, nursing mothers: not recommended.

Interactions:

Potentiates phenytoin, alcohol, other CNS depressants, propranolol. Potentiated by propranolol. Antagonized by anticholinergics. Atropine. Decreased guanethidine, anticoagulant effects.

See Also:

Chlorpromazine

Pharmacological Class:

Aliphatic phenothiazine.

Adverse Reactions:

Tardive dyskinesia, drowsiness, jaundice, blood dyscrasias, hypotension, retinopathy, may mask emetic signs of disease, lowered seizure threshold, rash, skin pigmentation, anticholinergic effects, insomnia, extrapyramidal reactions, neuroleptic malignant syndrome.

Note:

Formerly known under the brand name Thorazine.

How Supplied:

Contact supplier.

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