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Chlorothiazide
Edema
Hypertension
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Drug Name:

Chlorothiazide Rx

Generic Name and Formulations:
Chlorothiazide 250mg, 500mg; scored tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Chlorothiazide:

Edema.

Adult:

Initially 0.5g–1g once or twice daily, every other day, or 3–5 days/wk.

Children:

<6 months: up to 15mg/lb per day in 2 divided doses. ≥6 months: 10mg/lb per day in 2 divided doses.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (thiazide).

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand name Diuril.

How Supplied:

Contact supplier.

Indications for Chlorothiazide:

Hypertension.

Adult:

0.5–1g/day as single or divided doses; max 2g/day.

Children:

<6 months: up to 15mg/lb per day in 2 divided doses. ≥6 months: 10mg/lb per day in 2 divided doses.

Contraindications:

Anuria. Sulfonamide allergy.

Warnings/Precautions:

Renal or hepatic impairment. Arrhythmias. Diabetes. Gout. Asthma. SLE. Postsympathectomy. Excessive fluid loss. Monitor electrolytes, BUN (if high). Potassium supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Adjust antidiabetic, antigout medications. Antagonized by NSAIDs. ACTH, corticosteroids, amphotericin B increase hypokalemia risk. Hyperglycemia, hyperuricemia more likely with diazoxide. NSAIDs may cause renal failure. May potentiate nondepolarizing muscle relaxants, other antihypertensives. Hypotension with CNS depressants. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (thiazide).

Adverse Reactions:

Electrolyte disorders (esp. hypokalemia), hyperglycemia, hyperuricemia, photosensitivity, orthostatic hypotension, GI disturbances, adverse lipid values.

Note:

Formerly known under the brand name Diuril.

How Supplied:

Contact supplier.

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