Childhood Malignancy

Targeted Therapy Enhances Chemotherapy, Improves Outcomes in Retinoblastoma

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The effectiveness of chemotherapy was enhanced by targeting survivin, a protein that inhibits apoptosis or cell death, according to preclinical research in cells and mouse models of retinoblastoma.

New Therapy Holds Potential for Neuroblastoma Treatment

New Therapy Holds Potential for Neuroblastoma Treatment

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A new therapy might help treat a rare, high-risk cancer that begins development in the fetus or embryo, neuroblastoma, according to recent results from cell culture experiments.

Model Demonstrates Benefits of MRI Screening for Breast Cancer in Survivors of Childhood Hodgkin Lymphoma

Model Demonstrates Benefits of MRI Screening for Breast Cancer in Survivors of Childhood Hodgkin Lymphoma

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Female survivors of childhood Hodgkin lymphoma (HL) who received chest radiation can reduce their risk of breast cancer through early screening.

Long-term Attention and Learning Deficits Persist After Chemotherapy for Pediatric Leukemia

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Pediatric survivors of ALL treated only with chemotherapy remain at an increased risk for attention problems 2 years after treatment cessation.

Direct Measures of Body Composition, not BMI, Needed to Track Obesity During Leukemia Treatment

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Change in BMI does not reflect body composition of patients undergoing treatment for ALL, suggesting direct measures of body composition should be used to evaluate obesity in patients with leukemia.

Novel Test Offers Diagnostic and Disease Monitoring Potential for Rare Childhood Brain Cancer

A noninvasive, low-cost blood test was developed to help doctors diagnose some types of malignant childhood tumor. It could also enable treatment monitoring without exposing patients to repeated doses of radiation.

Inherited Gene Variation Linked to an Increased Risk of Pediatric Acute Lymphoblastic Leukemia (ALL)

Inherited Gene Variation Linked to an Increased Risk of Pediatric Acute Lymphoblastic Leukemia (ALL)

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Researchers studying two generations of a family affected by pediatric ALL identified an inherited variation in the ETV6 gene that is associated with an increased risk of developing the disease.

Ethnic, Racial, and Socioeconomic Disparities in Retinoblastoma in Children

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Ethnic, racial, and socioeconomic disparities appear to exist among children with retinoblastoma, a once uniformly fatal but now treatable eye cancer. Those disparities are associated with greater risks for advanced disease and undergoing removal of the eye.

Social Deprivation and Gender Impact Incidence of Hodgkin Lymphoma

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Living in overcrowded conditions appears to protect children and young adults against developing a subtype of Hodgkin lymphoma. The protective effect suggests that infections earlier in life may stimulate the immune system to deal with future infections and cancerous cells more efficiently.

Childhood Brain Tumors Affect Working Memory of Adult Survivors

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Adult survivors of childhood brain tumors have lower working memory performance compared with healthy adults, according to research from Georgia State University and Emory University, in Atlanta.

How the malaria parasite increases the risk of blood cancer

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A link between malaria and Burkitt's lymphoma was first described more than 50 years ago, but how a parasitic infection could turn immune cells cancerous has remained a mystery. Now, researchers have demonstrated in mice that B cell DNA becomes vulnerable to cancer-causing mutations.

Stem cell transplantation improves outcomes for children with rare form of leukemia

Stem cell transplantation improves outcomes for children with rare form of leukemia

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Greatly improved outcomes have been observed in using stem cell transplantation to treat patients with juvenile myelomonocytic leukemia (JMML), a rare form of blood cancer.

Group finds new method for identifying most aggressive childhood cancers

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A new method involving the study of genetic micro-variation, rather than the presence of individual mutations, could help identify malignant tumors in children.

Advances in creating treatment for common childhood blood cancer

Advances in creating treatment for common childhood blood cancer

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A new drug in development may offer analternative to standard chemotherapy for patient with T-cell acute lymphoblastic leukemia, according to new research.

Parents resilient after their children undergo stem cell transplant

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A recent study shows that, in the case of stem cell transplantation in a child, parents feel increased distress at the time of the procedure, but eventually recover.

Genetic development of immune system linked to leukemia

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Scientists have discovered a genetic signature that implicates a key mechanism in the immune system as a driving force for a type of childhood leukemia.

Genetic pathways may suggest more effective targeted therapies for childhood brain tumors

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A new study offers glimpses into how scientists will be using the ongoing flood of gene-sequencing data to customize treatments based on very specific mutations in a child's tumor.

Many children with retinoblastoma can safely forego adjuvant chemotherapy

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A prospective clinical trial conducted in France found that children with low-risk retinoblastoma do not need adjuvant chemotherapy to prevent disease recurrence or metastasis.

Biomarker may identify neuroblastomas with sensitivity to BET bromodomain inhibitors

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Neuroblastoma is frequently associated with the presence of MYCN amplification, a genetic biomarker associated with poor prognosis. Researchers have determined that these tumors are sensitive to a new class of drugs.

ONS Connections: Reliable biomarker for central nervous system tissue injury during pediatric leukemia treatment

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During the post-induction phase of treatment for childhood acute lymphoblastic leukemia (ALL), F2 isoprostanes significantly increase, allowing central nervous system (CNS) tissue injury to be monitored.

New radiation treatment method merciful for children with brain tumors

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For children who undergo brain radiation therapy, permanent neurocognitive adverse effects are a significant risk. These risks arise because the radiation often encounters healthy tissue, which reduces the formation of new cells, particularly in the hippocampus.

Whole-genome scan helps select best treatment for children with neuroblastoma

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Identifying large-scale chromosomal damage through a whole-genome scan can help doctors choose the best option for treatment of neuroblastoma in children.

Children with acute myeloid leukemia benefit from improved diagnostic test

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Flow cytometry has been identified as better for checking for minimal residual disease than two other widely used methods to predict patient survival.

Ridding cells of EYA3 boosts chemotherapy response in Ewing sarcoma

Scientists have identified a protein that makes some children and teenagers afflicted with Ewing sarcoma more resistant to chemotherapy.

Colorectal risk defined for childhood cancer survivors

Childhood cancer survivors may need earlier colorectal cancer screening, especially if abdominal radiation was part of their treatment.

Make genetic testing part of retinoblastoma care

Genetic evaluations by a multidisciplinary health team improved risk prediction for children with retinoblastoma and their relatives, and prevented overuse of clinical screening tests.

Wilms' tumour: Assessing and managing nephroblastoma

Reviews the clinical features and diagnosis of Wilm's tumor, as well as management and follow up

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