Childhood Cancer

Study Identifies Factors Associated With Platinum-induced Ototoxicity in Pediatric Cancer Survivors

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Large cohort study assesses the frequency of, and factors associated with, ototoxicity in childhood cancer survivors who received platinum agents without cranial irradiation.

Long-Term Health Not Improved for Childhood Cancer Survivors

Long-Term Health Not Improved for Childhood Cancer Survivors

Research shows only modest improvements in the physical or mental health of childhood cancer survivors in recent decades.

Childhood Cancer Linked to Poor Diet Quality in Adult Survivors

Childhood Cancer Linked to Poor Diet Quality in Adult Survivors

Epidemiologic study reveals the impact of cancer and its treatment on diet quality among adult survivors of childhood cancers.

Internalizing, Externalizing Behavioral Problems a Significant Postdiagnosis Concern in Children With Cancer

Internalizing, Externalizing Behavioral Problems a Significant Postdiagnosis Concern in Children With Cancer

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Children with cancer are at risk for developing behavioral problems after diagnosis.

Cancer Mortality Decrease Observed for Children and Adolescents

Cancer Mortality Decrease Observed for Children and Adolescents

A twenty percent decrease in cancer death rate among children and adolescents has taken place from 1999 to 2014.

Risk for Adverse Pulmonary Events Higher in Adult Survivors of Childhood Cancer

Risk for Adverse Pulmonary Events Higher in Adult Survivors of Childhood Cancer

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Adult survivors of childhood cancer are at increased risk for late adverse pulmonary events.

Comprehensive Mental Health Screening Recommended for Some Childhood Cancer Survivors

Comprehensive Mental Health Screening Recommended for Some Childhood Cancer Survivors

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Although most adolescent survivors of childhood cancer have no reported psychological symptoms, those who do often have multiple symptoms and distinct symptom profiles.

Young Adult Survivors of Childhood Cancers Experience Accelerated Aging

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Chronic conditions commonly affect long-term quality of life for survivors of childhood cancer who are in their young adult years.

Experimental Targeted Therapy Succeeds in Rare Pediatric Cancer

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The experimental treatment LOXO-101 led to remarkable improvement for a 20-month-old girl whose rare pediatric cancer did not respond to surgery or chemotherapy.

New Therapy Holds Promise for Patients With Ewing Sarcoma

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Two new compounds suppress tumor growth in cell culture and mouse xenograft models of Ewing sarcoma, a rare pediatric cancer. These 2 compounds are similar to mithramycin, also known as picamycin, a drug no longer manufactured due to its toxicity.

Anxiety and Depressive Symptoms Are Increased in Pediatric Survivors of Acute Lymphoblastic Leukemia

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Emotional distress during and after undergoing chemotherapy for ALL affects a significant percentage of children with the disease.

Study Findings Show Possible Association Between PreLabor Cesarean Delivery and Risk for ALL in Young Children

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The finding that prelabor cesarean delivery may have a correlation with acute lymphoblastic leukemia (ALL) may offer new targets for research into preventing cancer.

Standards Established for Psychosocial Care of Children With Cancer and Their Families

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A group of pediatric oncology psychosocial experts developed evidence-based standards for the care of children with cancer and their families.

ALK-positive anaplastic large cell lymphoma with prominent bone involvement in a 13-year-old boy

ALK-positive anaplastic large cell lymphoma with prominent bone involvement in a 13-year-old boy

[OncoTargets and Therapy] Anaplastic large cell lymphoma (ALCL) frequently involves the bone marrow, but primary or secondary involvement to the bone is rare. This article examines a case of anaplastic lymphoma kinase positive ALCL with prominent bone involvement in a young boy.

Proton Beam Therapy Treats Childhood Brain Cancer as Effectively as Standard Radiation

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Treating medulloblastoma with proton beam therapy results in survival rates in line with other proton therapies, according to recent study data.

Risk of Metabolic Syndrome Increased in Survivors of Childhood Cancer

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Early cardiovascular events are a risk for survivors of childhood cancer, according to researchers who also advocate for a unified definition of pediatric metabolic syndrome.

Proton Radiotherapy May Be Viable Option for Pediatric Brain Tumor

Proton Radiotherapy May Be Viable Option for Pediatric Brain Tumor

Phase 2 trial data showed acceptable toxicity and similar survival as conventional radiotherapy for childhood medulloblastoma.

Survivors of Childhood Cancer Affecting Vision Prone to Long-term Health Issues

Survivors of Childhood Cancer Affecting Vision Prone to Long-term Health Issues

Lifelong screening is recommended for survivors of childhood cancer that affects the vision, in order to detect issues early.

New Studies Reveal Long-Term Vision-related Health Concerns of Survivors of Childhood Retinoblastoma and Brain Cancer

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Two new studies investigate the impact of retinoblastoma on long-term health of survivors and the long-term psychological and socio-economic effects of blindness in survivors of brain tumors.

Considerable Subclinical Cardiac Disease in Adult Survivors of Childhood Cancer

Considerable Subclinical Cardiac Disease in Adult Survivors of Childhood Cancer

Exposure to anthracycline and heart radiation has been tied to higher odds of cardiac disease.

Association Is Found Between Bone Complications in Young Pediatric Patients With Leukemia and Gene Variations

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Variations in genes involved in normal bone development are associated with an 8- to 15-fold increased risk for osteonecrosis in young patients with acute lymphoblastic leukemia (ALL).

COG: Immunophenotypic Expression Profiles Can Help Predict Outcome in AML

COG: Immunophenotypic Expression Profiles Can Help Predict Outcome in AML

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Immunophenotypic expression profiles can provide a tool to discriminate cohorts of young patients with acute myeloid leukemia (AML) that have a high relapse probability.

No Survival Benefit to Fourth Chemo Course in Younger Patients with AML

No Survival Benefit to Fourth Chemo Course in Younger Patients with AML

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Although a fourth chemotherapy course may benefit younger patients with poor-risk acute myeloid leukemia, those with good and standard risk demonstrated little survival benefit from the additional course.

Antibiotic Prophylaxis During Induction Phase Reduces Infections in Pediatric ALL

Antibiotic Prophylaxis During Induction Phase Reduces Infections in Pediatric ALL

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Continuous antibiotic treatment can reduce infections in young patients with acute lymphoblastic leukemia (ALL).

Fractures Higher in Non-Hispanic Patients Treated for Newly Diagnosed Pediatric ALL

Fractures Higher in Non-Hispanic Patients Treated for Newly Diagnosed Pediatric ALL

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Non-Hispanic children undergoing treatment for newly diagnosed acute lymphoblastic leukemia reported higher rates of fractures and opportunistic infections, according to new study data.

High Remission Rate Seen With Arsenic Trioxide Consolidation for Children With Acute Promyelocytic Leukemia

High Remission Rate Seen With Arsenic Trioxide Consolidation for Children With Acute Promyelocytic Leukemia

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Increased rates of event-free surviva were seen with lthe use of arsenic trioxide consolidation for children newly diagnosed with acute promyelocytic leukemia (APL).

6MP Self-Reporting in Acute Lymphoblastic Leukemia Deemed 'Unreliable'

6MP Self-Reporting in Acute Lymphoblastic Leukemia Deemed 'Unreliable'

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Subjective over-reporting of 6-mercaptopurine (6MP) intake during maintenance therapy for childhood acute lymphoblastic leukemia is common, according to a new cohort study.

Risk of Several Autoimmune Diseases Increased in Childhood Cancer Survivors

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Childhood cancer survivors are at heightened risk of a wide range of autoimmune diseases. Diabetes and Addison's disease make up almost half of the excess cases, according to the findings.

Cause of a Childhood Kidney Cancer Is a Previously Unrecognized Role of a Known Gene

Cause of a Childhood Kidney Cancer Is a Previously Unrecognized Role of a Known Gene

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Genetic mutations in the REST gene have been shown to cause Wilms tumor, a rare kidney cancer that occurs in children. The findings identified mutations in the REST gene in 16 children with Wilms tumor.

Targeted Chemotherapy Shows Early Signs of Slowing Tumor Growth With Less Toxicity

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Surviving neuroblastoma as a child can come with just as many challenges as the cancer itself. But a team of surgeons is in the nascent stages of developing a more targeted method for delivering chemotherapy, with lower toxicity.

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