Childhood Cancer

FDA Approves Gemtuzumab Ozogamicin for CD-33 Positive Acute Myeloid Leukemia

FDA Approves Gemtuzumab Ozogamicin for CD-33 Positive Acute Myeloid Leukemia

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Gemtuzumab ozogamicin (Mylotarg) was granted US FDA approval for the treatment of relapsed or refractory CD-33 positive AML in patients ages 2 years and older and newly diagnosed CD-33 positive AML in adult patients.

CVD Risk Factors Identified in Long-Term Survivors of Pediatric Cancer

CVD Risk Factors Identified in Long-Term Survivors of Pediatric Cancer

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Study implicates higher doses of cardiac radiotherapy and exposure to high-dose anthracyclines.

Survivors of Pediatric Cancers Suffering Less From Chronic Diseases

Survivors of Pediatric Cancers Suffering Less From Chronic Diseases

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A decline in the incidence of serious chronic diseases in survivors of childhood cancer may be linked to changes in treatment protocols.

Whole Genome Sequencing Reveals that 12% of Childhood Cancer Survivors Have Mutations in Genes that Increase Cancer Risk

Whole Genome Sequencing Reveals that 12% of Childhood Cancer Survivors Have Mutations in Genes that Increase Cancer Risk

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Whole genome sequencing of more than 3000 survivors of childhood cancers demonstrates the value of genetic testing for potential second cancers in this population.

Arm Measurements a Better Assessment of Nutritional Status in Childhood Cancer Survivors

Arm Measurements a Better Assessment of Nutritional Status in Childhood Cancer Survivors

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Arm anthropometry is a better tool for assessing nutritional status of survivors of childhood cancer.

Mortality Rates Highest Among Youngest Oncology Patients, Particularly Minorities

Mortality Rates Highest Among Youngest Oncology Patients, Particularly Minorities

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Cancer deaths within 1 month of diagnosis occur most often in patients younger than 1 years, especially among Blacks and Hispanics.

Improved Survival, Fewer Second Cancers With Less Radiation Therapy for Childhood Cancers

Improved Survival, Fewer Second Cancers With Less Radiation Therapy for Childhood Cancers

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A significant reduction in use of radiation therapy to treat childhood cancers improved survival, reduced second cancers in survivors.

Study Suggest New Treatment Approaches for High-Risk Pediatric Leukemia

Study Suggest New Treatment Approaches for High-Risk Pediatric Leukemia

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Three specific genetic alterations may help identify pediatric patients with AMKL at high risk who may benefit from allogeneic stem cell transplants.

Prenatal Herpes Virus Infection May Increase Childhood Leukemia Risk

Prenatal Herpes Virus Infection May Increase Childhood Leukemia Risk

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Study results indicate that herpetic cytomegalovirus infection prior to birth subjects the child to increased odds of developing pediatric acute lymphoblastic leukemia.

Study Identifies Factors Associated With Platinum-induced Ototoxicity in Pediatric Cancer Survivors

Study Identifies Factors Associated With Platinum-induced Ototoxicity in Pediatric Cancer Survivors

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Large cohort study assesses the frequency of, and factors associated with, ototoxicity in childhood cancer survivors who received platinum agents without cranial irradiation.

Long-Term Health Not Improved for Childhood Cancer Survivors

Long-Term Health Not Improved for Childhood Cancer Survivors

Research shows only modest improvements in the physical or mental health of childhood cancer survivors in recent decades.

Childhood Cancer Linked to Poor Diet Quality in Adult Survivors

Childhood Cancer Linked to Poor Diet Quality in Adult Survivors

Epidemiologic study reveals the impact of cancer and its treatment on diet quality among adult survivors of childhood cancers.

Internalizing, Externalizing Behavioral Problems a Significant Postdiagnosis Concern in Children With Cancer

Internalizing, Externalizing Behavioral Problems a Significant Postdiagnosis Concern in Children With Cancer

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Children with cancer are at risk for developing behavioral problems after diagnosis.

Cancer Mortality Decrease Observed for Children and Adolescents

Cancer Mortality Decrease Observed for Children and Adolescents

A twenty percent decrease in cancer death rate among children and adolescents has taken place from 1999 to 2014.

Risk for Adverse Pulmonary Events Higher in Adult Survivors of Childhood Cancer

Risk for Adverse Pulmonary Events Higher in Adult Survivors of Childhood Cancer

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Adult survivors of childhood cancer are at increased risk for late adverse pulmonary events.

Comprehensive Mental Health Screening Recommended for Some Childhood Cancer Survivors

Comprehensive Mental Health Screening Recommended for Some Childhood Cancer Survivors

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Although most adolescent survivors of childhood cancer have no reported psychological symptoms, those who do often have multiple symptoms and distinct symptom profiles.

Young Adult Survivors of Childhood Cancers Experience Accelerated Aging

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Chronic conditions commonly affect long-term quality of life for survivors of childhood cancer who are in their young adult years.

Experimental Targeted Therapy Succeeds in Rare Pediatric Cancer

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The experimental treatment LOXO-101 led to remarkable improvement for a 20-month-old girl whose rare pediatric cancer did not respond to surgery or chemotherapy.

New Therapy Holds Promise for Patients With Ewing Sarcoma

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Two new compounds suppress tumor growth in cell culture and mouse xenograft models of Ewing sarcoma, a rare pediatric cancer. These 2 compounds are similar to mithramycin, also known as picamycin, a drug no longer manufactured due to its toxicity.

Anxiety and Depressive Symptoms Are Increased in Pediatric Survivors of Acute Lymphoblastic Leukemia

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Emotional distress during and after undergoing chemotherapy for ALL affects a significant percentage of children with the disease.

Study Findings Show Possible Association Between PreLabor Cesarean Delivery and Risk for ALL in Young Children

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The finding that prelabor cesarean delivery may have a correlation with acute lymphoblastic leukemia (ALL) may offer new targets for research into preventing cancer.

Standards Established for Psychosocial Care of Children With Cancer and Their Families

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A group of pediatric oncology psychosocial experts developed evidence-based standards for the care of children with cancer and their families.

ALK-positive anaplastic large cell lymphoma with prominent bone involvement in a 13-year-old boy

ALK-positive anaplastic large cell lymphoma with prominent bone involvement in a 13-year-old boy

[OncoTargets and Therapy] Anaplastic large cell lymphoma (ALCL) frequently involves the bone marrow, but primary or secondary involvement to the bone is rare. This article examines a case of anaplastic lymphoma kinase positive ALCL with prominent bone involvement in a young boy.

Proton Beam Therapy Treats Childhood Brain Cancer as Effectively as Standard Radiation

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Treating medulloblastoma with proton beam therapy results in survival rates in line with other proton therapies, according to recent study data.

Risk of Metabolic Syndrome Increased in Survivors of Childhood Cancer

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Early cardiovascular events are a risk for survivors of childhood cancer, according to researchers who also advocate for a unified definition of pediatric metabolic syndrome.

Proton Radiotherapy May Be Viable Option for Pediatric Brain Tumor

Proton Radiotherapy May Be Viable Option for Pediatric Brain Tumor

Phase 2 trial data showed acceptable toxicity and similar survival as conventional radiotherapy for childhood medulloblastoma.

Survivors of Childhood Cancer Affecting Vision Prone to Long-term Health Issues

Survivors of Childhood Cancer Affecting Vision Prone to Long-term Health Issues

Lifelong screening is recommended for survivors of childhood cancer that affects the vision, in order to detect issues early.

New Studies Reveal Long-Term Vision-related Health Concerns of Survivors of Childhood Retinoblastoma and Brain Cancer

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Two new studies investigate the impact of retinoblastoma on long-term health of survivors and the long-term psychological and socio-economic effects of blindness in survivors of brain tumors.

Considerable Subclinical Cardiac Disease in Adult Survivors of Childhood Cancer

Considerable Subclinical Cardiac Disease in Adult Survivors of Childhood Cancer

Exposure to anthracycline and heart radiation has been tied to higher odds of cardiac disease.

Association Is Found Between Bone Complications in Young Pediatric Patients With Leukemia and Gene Variations

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Variations in genes involved in normal bone development are associated with an 8- to 15-fold increased risk for osteonecrosis in young patients with acute lymphoblastic leukemia (ALL).

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